Lymph node metastasis in early gastric cancer

Neto, Guilherme Pinto Bravo; Santos, Elizabeth Gomes dos; Victer, Felipe Carvalho; Carvalho, Carlos Eduardo

doi:10.1590/s0100-69912014000100004

Cited by 27 publications

(28 citation statements)

References 25 publications

(47 reference statements)

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“…Univariate analysis showed that tumor size, the presence of middle and lower stomach cancer, poorly differentiated adenocarcinoma, signetring cell carcinoma, diffuse type cancer, and lymphatic invasion correlated with lymph node metastasis. Multivariate analysis showed that lymphatic invasion and tumor size were significant predictors of lymph node metastasis [13]. Similar findings were also observed in the present study.…”

Section: Discussionsupporting

confidence: 92%

The Risk Factors of Lymph Node Metastasis in Early Gastric Cancer

Fang

Huang

Lan³

et al. 2015

Pathol. Oncol. Res.

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Endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) is an effective alternative treatment for early gastric cancer. However, a major concern is the likelihood of lymph node metastasis. From December 1987 to December 2006, 391 patients who underwent curative surgery for gastric cancer with mucosal (T1a, n = 265) or submucosal (T1b, n = 126) invasion and a retrieved lymph node number ≧ 15 were enrolled. The frequency and risk factors of lymph node metastasis were analyzed. The frequency of lymph node metastasis was 4.9 % in T1a lesions and 21.4 % in T1b lesions. Although the depth of submucosal tumor invasion was < 2 mm, there was a 28.6 % chance of lymph node metastasis. A T1b lesion, i.e., the width of the submucosal tumor invasion was < 5 mm, resulted in fewer lymph node metastases than lesions > 5 mm in width. Multivariate analysis demonstrated that Lauren's diffuse type and lymphatic invasion were independent risk factors for lymph node metastasis in T1a lesions, while lymphatic invasion was the strongest risk factor for lymph node metastasis in T1b lesions. EMR/ESD is a good alternative for T1a intestinal type adenocarcinoma without lymphatic invasion. Surgical resection is necessary for patients with T1b gastric cancer with lymphatic invasion.

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Section: Discussionsupporting

confidence: 92%

The Risk Factors of Lymph Node Metastasis in Early Gastric Cancer

Fang

Huang

Lan³

et al. 2015

Pathol. Oncol. Res.

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“…The results demonstrated that RP11-119F7.4 had potential diagnostic value in gastric cancer and further indicated that increased expression levels tended to be associated with Borrmann type IV and diffuse-type gastric cancer. A number of previous studies have indicated that Borrmann type IV and diffuse Lauren-type gastric cancers were associated with a worse prognosis compared with other types (32,33). According to the results of the present study, RP11-119F7.4 expression levels may be associated with tumorigenesis and the level of malignancy in gastric cancer.…”

Section: A B Discussionsupporting

confidence: 69%

Novel long non-coding RNA RP11-119F7.4 as a potential biomarker for the development and progression of gastric cancer

et al. 2015

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Abstract. Long non-coding RNAs (lncRNAs) have been reported to be involved in gene dysregulation in numerous different types of cancer, and have subsequently emerged as a major series of regulatory molecules that participate in a broad range of biological and pathological processes. However, the correlation between the expression levels of lncRNAs and their clinical significance in gastric cancer remains unclear. The aim of the present study was to investigate the potential correlation between lncRNA RP11-119F7.4 expression and clinicopathological characteristics in gastric cancer, and to identify whether it can serve as a potential diagnostic biomarker of the disease. Total RNA was extracted from the tissues of 96 patients with gastric cancer, in addition to matched non-tumor adjacent tissues (NATs). Following reverse transcription, lncRNA RP11-119F7.4 expression levels were determined by quantitative polymerase chain reaction and the association with patient clinicopathological characteristics was further analyzed. A receiver operating characteristic (ROC) curve was constructed to determine the diagnostic value of RP11-119F7.4. The results demonstrated that RP11-119F7.4 expression was significantly downregulated in the gastric cancer tissues compared with the matched NATs (P<0.001) and was significantly associated with the macroscopic type (P=0.041) and Lauren grade (P=0.020). The area under the ROC curve was 0.637 (P<0.001). However, no statistically significant differences were observed between RP11-119F7.4 expression and patient survival. The results of the present study indicate that lncRNA RP11-119F7.4 may be involved in carcinogenesis and may prove useful as a biomarker for diagnosis and prognostic significance in patients with gastric cancer.

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“…However, many studies from Japan and other countries have not demonstrated significant differences in the rate of LNM between early PGC (i.e., carcinoma in the upper one‐third stomach in Japan) and DGC. This may be due to the small sample sizes of PGC . The recent discovery of different genomic profiles of PGC, compared to those of DGC, may explain why early PGC, unlike early DGC, exhibits a very low risk of LNM and therefore may be more suitable than early DGC for endoscopic resection.…”

Section: Discussionmentioning

confidence: 99%