O índice de linfonodos comprometidos como um preditor para a ocorrência de recidivas tumorais no câncer de cólon estádio III

Silva, Tiago Luis Dedavid e; Damin, Daniel de Carvalho

doi:10.1590/s0100-69912013000600008

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…In our results, there was a significant correlation between high mLNRs and worse survival in CRC. As the prognostic implications of mLNR are controversial between studies, detailed analyses are needed to examine mLNRs in CRC [17,18,19,20,21,22,23,27,28,29,30,31,32,33].…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Implication of Metastatic Lymph Node Ratio in Colorectal Cancers: Comparison Depending on Tumor Location

Pyo

Shin

Kang

2019

JCM

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Background: The proportion of the number of involved lymph nodes (LNs) to the number of examined LNs—defined as metastatic LN ratio (mLNR)—has been considered as a prognostic parameter. This study aims to elucidate the prognostic implication of the mLNR in colorectal cancer (CRC) according to the tumor location. Methods: We evaluated the correlation between prognoses and the involved and examined LNs as well as mLNR according to the tumor location in 266 surgically resected human CRCs. Besides, to evaluate the optimal cutoff for high and low mLNRs, we investigated the correlation between mLNR and survival according to the various cutoffs. Results: LN metastasis was found in 146 cases (54.9%), and colon and rectal cancers were found in 116 (79.5%) and 30 (20.5%) of the cases, respectively. The mean mLNRs were significantly higher in rectal cancer than in colon cancer (0.38 ± 0.28 vs. 0.21 ± 0.24, P = 0.003). Besides this, the number of involved LNs in rectal cancer was significantly high compared to colon cancer (11.83 ± 10.92 vs. 6.37 ± 7.78, P = 0.014). However, there was no significant difference in the examined LNs between the rectal and colon cancers (31.90 ± 12.28 vs. 36.60 ± 18.11, P = 0.181). In colon cancer, a high mLNR was significantly correlated with worse survival for all cutoffs (0.1, 0.2, 0.3, and 0.4). However, rectal cancer only showed a significant correlation between high mLNR and worse survival in the subgroup with a cutoff of 0.2. Conclusions: Our results showed that high mLNR was significantly correlated with worse survival. The number of involved LNs and mLNRs were significantly higher in rectal cancer than in colon cancer. The cutoff of 0.2 can be useful for the differentiation of prognostic groups, regardless of tumor location.

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Section: Discussionmentioning

confidence: 99%

“…Berger et al first reported the prognostic role of mLNR in CRC [16], though no detailed information regarding the criteria for high mLNR is currently available. Recently, the mLNR has been explored as a prognostic factor on survival outcomes and time to progression for patients with colon cancer [17,18,19,20,21,22,23,24,25,26].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Implication of Metastatic Lymph Node Ratio in Colorectal Cancers: Comparison Depending on Tumor Location

Pyo

Shin

Kang

2019

JCM

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“…Eligible studies of the present meta-analysis with criteria for high mLNR were ranged from 0.125 to 0.3. The criteria for high mLNR in eligible studies were defined by independent guidelines [7,8,9,10,11,12,13,14,15,16,17,18,19,20]. Also, each study included CRCs with various tumor stages and population.…”

Section: Discussionmentioning

confidence: 99%

“…Two independent authors extracted data from all eligible studies. The selected data were obtained from each of the eligible studies [7,8,9,10,11,12,13,14,15,16,17,18,19,20]: We collected the author’s first name, the publication year of articles, the location of the research, number of patients analyzed, and the correlation between high mLNR and survival rates. The correlation between high mLNR and survival outcomes was evaluated according to the hazard ratio (HR) for the quantitative aggregation of survival results.…”

Section: Methodsmentioning

confidence: 99%

Metastatic Lymph Node Ratio (mLNR) is a Useful Parameter in the Prognosis of Colorectal Cancer; A Meta-Analysis for the Prognostic Role of mLNR

et al. 2019

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Background and objectives: The presenting study aimed to elucidate the prognostic role of the metastatic lymph node ratio (mLNR) in patients with colorectal cancer (CRC), using a meta-analysis. Materials and Methods: Using data from 90,274 patients from 14 eligible studies, we performed a meta-analysis for the correlation between mLNR and survival rate. Besides, subgroup analyses were performed, based on tumor stage, tumor location, and mLNR. Results: A high mLNR showed significant correlation with worse overall survival and disease-free survival rates in CRC patients (hazard ratio (HR), 1.617, 95% confidence interval (CI) 1.393–1.877, and HR 2.345, 95% CI 1.879–2.926, respectively). In patients with stage III, who had regional LN metastasis, the HRs were 1.730 (95% CI 1.266–2.362) and 2.451 (95% CI 1.719–3.494) for overall and disease-free survival, respectively. According to tumor location, rectal cancer showed a worse survival rate when compared to colon cancer. In the analysis for overall survival, when mLNR was 0.2, HR was the highest across the different subgroups (HR 5.040, 95% CI 1.780–14.270). However, in the analysis for disease-free survival, the subgroup with an mLNR < 0.2 had a higher HR than the other subgroups (HR 2.878, 95% CI 1.401–5.912). Conclusions: The mLNR may be a useful prognostic factor for patients with CRC, regardless of the tumor stage or tumor location. Further studies are necessary for the detailed criteria of mLNR before its application in daily practice.

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“…The median fiveyear survival rate may range from 44% to 84% [6,7]. Clinically non-detected micrometastases may exist, increasing the risk of tumor recurrence.…”

Section: Discussionmentioning

confidence: 99%

FDG-PET/CT-Positive Foreign Body Granuloma Mimicking Colon Cancer Recurrence: Case Report

Leão¹,

Mororó²,

Carvalho³

et al. 2017

J Neoplasm

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Colorectal cancer (CRC) is the third most prevalent malignancy worldwide, and one of the most common causes of cancer-related deaths. The main tumor-related prognostic factor after surgical resection is initial pathologic staging and lymph node involvement is a major determinant of disease recurrence. The addition of adjuvant chemotherapy in stage III patients undergoing surgical resection decreases tumor recurrence by around 40% to 50%. However, a significant proportion of patients still experience systemic recurrence. In CRC, 18F-FDGfluorodeoxyglucose (18F-FDG-PET-CT) plays a key role in the detection of recurrent disease in post-therapy assessment of residual masses and patient staging before surgical resection of liver metastases. We report the case of a 52-year-old patient with stage III colorectal cancer, who underwent surgical resection and completed adjuvant chemotherapy, followed by imaging techniques (Fluorine-18-FDG PET-CT and magnetic resonance) mimicking early peritoneal and ovarian recurrence.

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O índice de linfonodos comprometidos como um preditor para a ocorrência de recidivas tumorais no câncer de cólon estádio III

Abstract: Lymph node ratio is a strong predictor for tumor recurrence in stage III colon cancer.

Cited by 7 publications

References 33 publications

Prognostic Implication of Metastatic Lymph Node Ratio in Colorectal Cancers: Comparison Depending on Tumor Location

Prognostic Implication of Metastatic Lymph Node Ratio in Colorectal Cancers: Comparison Depending on Tumor Location

Metastatic Lymph Node Ratio (mLNR) is a Useful Parameter in the Prognosis of Colorectal Cancer; A Meta-Analysis for the Prognostic Role of mLNR

FDG-PET/CT-Positive Foreign Body Granuloma Mimicking Colon Cancer Recurrence: Case Report

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