Análise da diversidade da microbiota intestinal de ratos submetidos à ressecção da valva ileocecal e criação de esfíncter artificial

Barra, Ângela Aparecida; Silva, Alcino Lázaro da; Rena, Cícero de Lima; Furtado, Maria Cristina Vasconcelos; Ferreira, Alessandra Barbosa; Nagen, Marcelo; Freitas, Fernanda

doi:10.1590/s0100-69912012000600013

Cited by 5 publications

(4 citation statements)

References 20 publications

(25 reference statements)

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“…There was alteration of the intestinal microbiota only in resected ileocecal valve group, that was greater in the terminal ileum than in the colon.In this study, was found an increase in the thickness and inflammatory infiltrate in the colon of GII animals. The microbiota alterations demonstrated by Barra et al 2 may be correlated to this finding. Saad et al 16 observed that extended intestinal resection did not determine significant weight loss after 60 postoperative days compared to control.…”

Section: Discussionmentioning

confidence: 59%

“…Barra et al 2 studied the consequences of ileocecal valve resection without enterectomy in intestinal microbiota. There was alteration of the intestinal microbiota only in resected ileocecal valve group, that was greater in the terminal ileum than in the colon.In this study, was found an increase in the thickness and inflammatory infiltrate in the colon of GII animals.…”

Section: Discussionmentioning

confidence: 99%

“…It´s most frequent causes in the pediatric group are necrotizing enteritis, intestinal atresia and small intestine volvulus; in adults inflammatory bowel disease, mesenteric ischemia and small intestine obstruction are more prevalent. In this situation, the mucosal surface of the remaining intestine may take up till two years to be adapted 2 , 22 .…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Ileocecal Valve Removal in a Model of Short Bowel Syndrome

Soler¹,

Lee²,

D’Albuquerque³

et al. 2019

ABCD, arq. bras. cir. dig.

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Background:Short bowel syndrome is a harmful condition that needs experimental research. Aim:To assess the impact of the ileocecal valve removal in a model of short bowel syndrome, in order to investigate the evolution of the colon under this circumstance. Method:Fifteen Wistar rats were equitable divided into: Control (Sham), Group I (70% enterectomy preserving ileocecal valve) and Group II (70% enterectomy excluding ileocecal valve). After enterectomy was performed jejunoileal or jejunocecal anastomosis and sacrificed the animals on 30th postoperative day for histomorphometric study of the colon. During this period, was observed the clinical evolution of the animals weekly including body weight measurement. Results:Group I and II presented progressive loss of weight. In Group I was observed diarrhea, perineal hyperemia and purple color of the colon during autopsy. Histomorphometry assay showed hypertrophy and hyperplasia of colon mucosa in Group I. In Group II the colon wall was thicker due to hypertrophy and muscular hyperplasia, and in mucosa vascular proliferation and inflammatory infiltrate were intense. Conclusion:This short bowel syndrome model is relevant and achieve 100% of survival. Animal’s weight loss was not altered by the presence or exclusion of the ileocecal valve. Animals with 70% of small bowel removal and presence of the ileocecal valve attained a better clinical evolution and histological colon adaptation than those without ileocecal valve.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of Ileocecal Valve Removal in a Model of Short Bowel Syndrome

Soler¹,

Lee²,

D’Albuquerque³

et al. 2019

ABCD, arq. bras. cir. dig.

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“…Other research has indicated that terminal ileum could be the main place where bacterial translocation occurs, due to ileocecal reflux under intestinal ischemia/reperfusion conditions [31, 32]. Therefore, ileostomy may prevent bacterial translocation besides having the merits of minimal trauma.…”

Section: Discussionmentioning

confidence: 99%

Acute Colonic Pseudo-Obstruction with Feeding Intolerance in Critically Ill Patients: A Study according to Gut Wall Analysis

Zhao

Xie

et al. 2017

Gastroenterology Research and Practice

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Objective. To compare the differences between acute colonic pseudo-obstruction (ACPO) with and without acute gut wall thickening. Methods. ACPO patients with feeding tolerance were divided into ACPO with no obvious gut wall thickening (ACPO-NT) group and ACPO with obvious acute gut wall thickening (ACPO-T) group according to computed tomography and abdominal radiographs. Patients' condition, responses to supportive measures, pharmacologic therapy, endoscopic decompression, and surgeries and outcomes were compared. Results. Patients in ACPO-T group had a significantly higher APACHE II (11.82 versus 8.25, p = 0.008) and SOFA scores (6.47 versus 3.54, p < 0.001) and a significantly higher 28-day mortality (17.78% versus 4.16%, p = 0.032) and longer intensive care unit stage (4 versus 16 d, p < 0.001). Patients in ACPO-NT group were more likely to be responsive to supportive treatment (62.50% versus 24.44%, p < 0.001), neostigmine (77.78% versus 17.64%, p < 0.001), and colonoscopic decompression (75% versus 42.86%, p = 0.318) than those in ACPO-T group. Of the patients who underwent ileostomy, 81.25% gained benefits. Conclusions. ACPO patients with gut wall thickening are more severe and are less likely to be responsive to nonsurgical treatment. Ileostomy may be a good option for ACPO patients with gut wall thickening who are irresponsive to nonsurgical treatment.

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Adult hypertensive rats are more prone to gut microflora perturbation and fibrosis in response to moderate restraint stress

Wang

Gao

et al. 2023

Translational Research

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Análise da diversidade da microbiota intestinal de ratos submetidos à ressecção da valva ileocecal e criação de esfíncter artificial

Abstract: ileocecal resection led to changes in ileal microbiota and, with the creation of new sphincter, the changes were even greater.

Cited by 5 publications

References 20 publications

The Effect of Ileocecal Valve Removal in a Model of Short Bowel Syndrome

The Effect of Ileocecal Valve Removal in a Model of Short Bowel Syndrome

Acute Colonic Pseudo-Obstruction with Feeding Intolerance in Critically Ill Patients: A Study according to Gut Wall Analysis

Adult hypertensive rats are more prone to gut microflora perturbation and fibrosis in response to moderate restraint stress

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