Lesões impalpáveis da mama marcadas com suspensão de carvão: avaliação de aspectos anatomopatológicos, viabilidade de interpretação e resposta inflamatória

Cavalcanti, Teresa Cristina Santos; Malafaia, Osvaldo; Nassif, Paulo Afonso Nunes; Skare, Thelma Larocca; Ogata, Daniel Cury; Miguel, Marcelo Tizzot; Gomes, Larissa Krüger

doi:10.1590/s0100-69912012000600005

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…No interference or disruption was reported by the pathologists at our institution during the preparation and examination of the specimens ( Figure 2(h) ). Cavalcanti et al previously described the formation of an inflammatory reaction, in which they demonstrated the presence of carbon particles in the cytoplasm of macrophages in all cases, but they also confirmed that this inflammatory reaction and the presence of carbon posed no difficulty, and the pathological diagnosis was made directly [ 23 ].…”

Section: Discussionmentioning

confidence: 88%

Effectiveness of Carbon Localization for Invasive Breast Cancer: An Institutional Experience

et al. 2023

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Introduction. The final oncological and aesthetic results of breast-conserving surgery (BCS) are influenced by the precise localization of breast cancer (BC) tumors and by the quality of the intraoperative margin assessment technique. This study aimed to assess the effectiveness of the carbon localization (CL) technique by determining the success rate of BC identification and the proportion of adequate complete resection of BC lesions. Methods. We conducted a cross-sectional retrospective study of patients treated with primary BCS for invasive BC who underwent CL of their BC lesion at the Jules Bordet Institute between January 2015 and December 2017. Descriptive statistics with categorical and continuous variables were used. The success rate of tumor identification and the rate of adequate excision were calculated using the test of percentages for independent dichotomous data. Results. This study included 542 patients with 564 nonpalpable BC lesions. The median pathological tumor size was 12 mm. Of these, 460 were invasive ductal carcinomas. Most of the tumors were of the luminal subtype. CL was performed using ultrasound guidance in 98.5% of cases. The median delay between CL and surgery was 5 days, with 46% of the patients having CL one day before surgery. The lumpectomy weighed 38 g on average, with a median diameter of the surgical sample at 6 cm and a median volume of 44 cm3 (6–369). One-stage complete resection was successfully performed in 93.4% of cases. In 36% of cases, an intraoperative re-excision was performed, based on intraoperative macroscopic pathological margin evaluation. The tumor was identified in 98.9% of cases in the breast surgical specimen. Conclusion. This study demonstrated high success rates for BC tumor identification (99%) and one-stage complete resection (93.4%) after BCS and CL. These results show that CL is an effective, simple, and inexpensive localization technique for successful excision of BC lesions during BCS.

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Section: Discussionmentioning

confidence: 88%

Effectiveness of Carbon Localization for Invasive Breast Cancer: An Institutional Experience

et al. 2023

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“…Besides, it does not need to be inoculated shortly before the surgery. In a Brazilian study, only 1.48% of the lesions were not located, proving that it can be a safe technique 11 . Nonetheless, it has major drawbacks not found in dyes, such as the possibility of forming a foreign body or microabscesses, which could harm the histopathological analysis of the tissue 11,12 .…”

Section: Discussionmentioning

confidence: 96%

“…None of the women marked with patent blue or other dyes had allergic events. Allergic reactions are rare, but due to their potential risk to life, marking with dyes should be avoided in patients who have allergic history and the procedure should be performed in places with infrastructure for immediate resuscitation in case of anaphylactic shock 1, 11 .…”

Section: Discussionmentioning

confidence: 99%

Use of dye in the preoperative marking of nonpalpable breast lesions literature review

Filho¹,

Moura²,

Gomes³

et al. 2019

Mastology

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Objetivo: Avaliar e comparar o uso de diferentes corantes na marcação de lesões não palpáveis de mama que possuem indicação para ressecção cirúrgica. Método: Foram analisadas as seguintes variáveis: número de casos, tipos de corante, técnica utilizada na marcação (azul patente, indocianina verde ou azul de metileno), técnicas associadas (fio-guia ou TC-99), margens livres do espécime cirúrgico (quando o diagnóstico era câncer), dor durante a marcação e eventos alérgicos. Organizou-se os principais resultados dos artigos em tabelas, utilizando o programa Microsoft Excel 2011. Resultados: Foram selecionados 11 artigos para análise. Ao todo, 510 mulheres realizaram marcação com corantes em 516 lesões impalpáveis de mama. Os principais corantes utilizados foram azul patente, azul de metileno e indocianina verde. A taxa de margens livres em casos de câncer foi de 95%. O azul de metileno foi superior aos demais corantes na obtenção de margens livres. Dos 11 artigos selecionados, em três foi feita a associação do corante com materiais radioativos, e em dois, com o fio guia. A dor durante a marcação foi analisada por dois estudos e classificada como moderada ou mínima por 75% das pacientes, sendo a mamografia o método mais associado à dor. Não foram reportados eventos alérgicos. Conclusão: O uso de corantes na marcação pré-operatória de lesões impalpáveis de mama é uma técnica viável, segura e mais barata. Os resultados iniciais de diversos grupos apontam vantagens significativas em relação aos métodos disponíveis atualmente. O azul de metileno apresenta menor taxa de margens comprometidas em relação aos demais corantes. Estudos prospectivos randomizados ainda são necessários para atestar a superioridade da técnica em relação às demais. ABSTRACTObjective: To evaluate and compare the use of different dyes in the marking of nonpalpable breast lesions indicated for surgical resection. Method: We analyzed the following variables: number of cases, types of dye, technique used for marking (patent blue, indocyanine green, or methylene blue), associated techniques (guidewire or Tc-99m), free margins of the surgical specimen (when the diagnosis was cancer), pain during the marking, and allergic events. The main results of the articles were organized in tables, using the software Microsoft Excel 2011. Results: We selected 11 articles for analysis. A total of 510 women had 516 nonpalpable breast lesions marked with dyes. The main dyes used were patent blue, methylene blue, and indocyanine green. The rate of free margins in cancer cases was 95%. Methylene blue was superior to other dyes in obtaining free margins. Out of the 11 articles selected, three associated dye with radioactive materials, and two with guidewire. Two studies analyzed the pain during the marking and revealed that 75% of the patients classified it as moderate or minimal, with mammography being the method most associated with pain. No allergic event was reported. Conclusion: The use of dyes in the preoperative marking of nonpalpable breast lesions is a viable, safe...

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Breast Imaging Preoperative Localization Procedure

Skaf

Catani

Ogata

2021

Modern Breast Cancer Imaging

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Lesões impalpáveis da mama marcadas com suspensão de carvão: avaliação de aspectos anatomopatológicos, viabilidade de interpretação e resposta inflamatória

Cited by 7 publications

References 25 publications

Effectiveness of Carbon Localization for Invasive Breast Cancer: An Institutional Experience

Effectiveness of Carbon Localization for Invasive Breast Cancer: An Institutional Experience

Use of dye in the preoperative marking of nonpalpable breast lesions literature review

Breast Imaging Preoperative Localization Procedure

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