Formas digestivas da doença de Chagas e carcinogênese: um estudo de associação

Gullo, Caio Eduardo; Estofolete, Cássia Fernanda; Gil, Cristiane Damas; Christiano, Adriana Borgonovi; Netinho, João Gomes

doi:10.1590/s0100-69912012000200011

Cited by 7 publications

(2 citation statements)

References 23 publications

(37 reference statements)

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“…There are several well-known risk factors for the development of squamous cell carcinoma of the esophagus, but two remain controversial: chagasic megaesophagus caused by neglected Chagas disease, endemic in Latin and South America regions and considered a significant public health problem 16,17,38 ; and persistent HPV infection, which has been suggested since the early 1980s as a potential risk factor 9,10 . However, no studies have by now investigated the possible association between HPV detected in patients with chagasic megaesophagus associated with esophageal cancer.…”

Section: Discussionmentioning

confidence: 99%

HPV detection within a case series of chagasic megaesophagus associated or not with esophageal squamous cell carcinoma

Munari

Sichero

Cruvinel-Carloni

et al. 2020

Preprint

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Background Chagasic megaesophagus (clinical manifestation of chagasic disease) has been reported as an etiological factor for squamous cell carcinoma of the esophagus, as well as the presence of human papillomavirus (HPV). Objective We accessed the prevalence of HPV DNA in a series of squamous cell carcinomas of the esophagus associated or not with the chagasic megaesophagus, and within samples of chagasic megaesophagus without cancer. Data obtained was further correlated to the pathological clinical data of affected individuals. Methods Retrospective study that used a total 92 samples tissue/biopsy specimens of formalin fixed and paraffin embedded tissues were retrospectively collected from the southeast region of Brazil from patients treated in three hospitals: Barretos Cancer Hospital, Barretos, São Paulo; Federal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais; and São Paulo State University (UNESP), Botucatu, São Paulo. Cases were divided in three groups: i) 24 patients with chagasic megaesophagus associated with esophageal ESCC (CM/ESCC); ii) 37 patients with esophageal ESCC without chagasic megaesophagus (ESCC); iii) 31 patients with chagasic megaesophagus without esophageal ESCC (CM). Results We detected a higher prevalence of high-risk HPVs in patients from both CM (12/31, 38.8%) and CM/ESCC groups (8/24, 33.3%), as compared to individuals of the ESCC group (6/37, 16.3%), although data was not statistically significant. We further observed that HPV-16 was more prevalent in patients of the ESCC (4/9, 44.5%) and CM/ESCC groups (2/8, 25.0%). In addition, some of these samples presented infection by multiple HPV types. High-risk HPVs detected were HPV-31, 45, 51, 53, 56, 66, and 73, of which the majority was identified in patients from the CM group. Furthermore, low-risk HPV-11 and HPV-70 were identified in individuals from both ESCC and CM groups. Conclusion This is the first report regarding the presence of HPV DNA in megaesophagus associated with esophageal squamous cell carcinoma. In the present study, HPV infection appears to be directly related to the development of esophageal squamous cell carcinoma in patients with chagasic megaesophagus. Further studies are warrantee to confirm and better understand the role of oncogenic HPV persistent infection in these patients.

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Section: Discussionmentioning

confidence: 99%

HPV detection within a case series of chagasic megaesophagus associated or not with esophageal squamous cell carcinoma

Munari

Sichero

Cruvinel-Carloni

et al. 2020

Preprint

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“…(6) In this way, the modifications that occur in a chronic infection by Trypanosoma cruzi (T. cruzi), especially myoenteric denervation, responsible for the digestive forms of the disease, have a close relation with the etiopathogeny of colorectal carcinogenesis. (7) According to the last global estimate, colon and rectal cancer are the third most common type among men, with 17,380 new cases a year, and the second most common type of cancer in women, with 18,980 new cases in 2018. (8) Various molecules participate in the inflammatory condition in Chagas disease, among which, galactic 3 (Gal-3).…”

Section: ❚ Resumomentioning

confidence: 99%

Although with intact mucosa at colonoscopy, chagasic megacolons have an overexpression of Gal-3

Garvil

Furtado

Lima

et al. 2020

Einstein (São Paulo)

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Objective: To evaluate the density of anti-galectin-3-immunostained cells, collagen percentage, mast cell density and presence of pathological processes in intestinal muscle biopsies of patients. Methods: Thirty-five patients who underwent intestinal biopsy were selected from 1997 to 2015. Patients were divided into three groups: chagasic patients with mucosal lesion (n=13), chagasic patients with intact mucosa (n=12) and non-chagasic patients with no mucosal lesion (n=10). Histological processing of the biopsied fragments and immunohistochemistry for galectin-3 were performed. Additional sections were stained with hematoxylin and eosin to evaluate the general pathological processes, picrosirius for evaluation of collagen and toluidine blue to evaluate the mast cell density. Results: Patients of mucosal lesion group had a significantly higher frequency of ganglionitis and myositis when compared to the chagasic patients with intact mucosa and non-chagasic group. The density of anti-galectin-3-immunostained cells was significantly higher in the chagasic patients with intact mucosa group when compared to the non-chagasic group. The group of chagasic patients with intact mucosa presented a higher percentage of collagen in relation to the patients with mucosal lesion and to the non-chagasic group, with a significant difference. There was no significant difference in mast cell density among the three groups. Conclusion: The higher density of anti-galectin-3-immunostained cells in patients in the chagasic patients with intact mucosa group suggested the need for greater attention in clinical evaluation of these patients, since this protein is associated with neoplastic transformation and progression.

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Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent

et al. 2017

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Formas digestivas da doença de Chagas e carcinogênese: um estudo de associação

Cited by 7 publications

References 23 publications

HPV detection within a case series of chagasic megaesophagus associated or not with esophageal squamous cell carcinoma

HPV detection within a case series of chagasic megaesophagus associated or not with esophageal squamous cell carcinoma

Although with intact mucosa at colonoscopy, chagasic megacolons have an overexpression of Gal-3

Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent

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