Ácido tranexâmico no tratamento da hemorragia no trauma

Luz, Luis Da; Sankarankutty, Ajith Kumar; Passos, Edward; Rizoli, Sandro; Fraga, Gustavo Pereira; Nascimento, Bartolomeu

doi:10.1590/s0100-69912012000100015

Cited by 14 publications

(8 citation statements)

References 5 publications

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“…Fixation in buffered formalin to make the slides and study of mitosis with Hematoxylin Eosin (HE) was performed. Slides were also prepared following the method of Tissue Microarray (TMA), characterized by Proliferating Cell Nuclear Antigen (PCNA), for immunohistochemistry quantification of hepatocytes in the replication phase 13 , 15 .…”

Section: Methodsmentioning

confidence: 99%

Tranexamic Acid Action on Liver Regeneration After Partial Hepatectomy: Experimental Model in Rats

Sobral

Daga

Rasera

et al. 2016

ABCD, arq. bras. cir. dig.

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Background: Different lesions may affect the liver resulting in harmful stimuli. Some therapeutic procedures to treat those injuries depend on liver regeneration to increase functional capacity of this organ. Aim: Evaluate the effects of tranexamic acid on liver regeneration after partial hepatectomy in rats. Method: 40 rats (Rattus norvegicus albinus, Rodentia mammalia) of Wistar-UP lineage were randomly divided into two groups named control (CT) and tranexamic acid (ATX), with 20 rats in each. Both groups were subdivided, according to liver regeneration time of 32 h or seven days after the rats had been operated. The organ regeneration was evaluated through weight and histology, stained with HE and PCNA. Results: The average animal weight of ATX and CT 7 days groups before surgery were 411.2 g and 432.7 g, and 371.3 g and 392.9 g after the regeneration time, respectively. The average number of mitotic cells stained with HE for the ATX and CT 7 days groups were 33.7 and 32.6 mitosis, and 14.5 and 14.9 for the ATX and CT 32 h groups, respectively. When stained with proliferating cell nuclear antigen, the numbers of mitotic cells counted were 849.7 for the ATX 7 days, 301.8 for the CT 7 days groups, 814.2 for the ATX 32 hand 848.1 for the CT 32 h groups. Conclusion: Tranexamic acid was effective in liver regeneration, but in longer period after partial hepatectomy.

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Section: Methodsmentioning

confidence: 99%

Tranexamic Acid Action on Liver Regeneration After Partial Hepatectomy: Experimental Model in Rats

Sobral

Daga

Rasera

et al. 2016

ABCD, arq. bras. cir. dig.

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“…Um estudo conduzido por Luz, et al (2012), em pacientes com hemorragias mostrou que, em um primeiro momento, os pacientes foram tratados com medicações que não seriam a base de ferro, e em sua minoria nos casos mais graves, eles foram submetidos a transfusões.…”

Section: Resultsunclassified

Anemias em pacientes internados em um hospital de Teixeira Soares-PR / Anemia in patients admitted to a hospital in Teixeira Soares-PR

Costa¹,

Modrow²,

Luz³

et al. 2021

BJDV

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A anemia é a concentração de hemoglobina baixa no sangue e estima-se que mais de dois bilhões de pessoas no mundo são anêmicas. O exame hemograma que avalia a quantidade de hemoglobina, sendo que para ser indicativo de anemia no sexo feminino a hemoglobina deve estar abaixo de 12g/dL e no sexo masculino abaixo de 13g/dL. O objetivo dessa pesquisa foi determinar a frequência de anemias em pacientes internados bem como o tratamento prescrito no Hospital de Teixeira Soares-PR, no período de Abril de 2020 a Janeiro de 2021. A amostra foi constituída dos dados de prontuários e resultados de hemogramas de todos os pacientes internados no período. Foi realizada classificação morfológica da anemia, classificação do diagnóstico prescrito pelo Hospital e tratamento realizado. Entre as análises obteve-se prevalência de anemias em 21,33% dos pacientes internados e, houve prevalência de 42,19% de anemias decorrentes de doença crônica sendo a prevalência de 68,75% de normocitose/normocromia. As contribuições deste estudo foram evidenciar a alta prevalência de anemias em pacientes hospitalizados; que a anemia mais frequente foi a anemia de doença crônica e mostrar a necessidade de maior cuidado por parte dos profissionais de saúde na interpretação desses casos anêmicos.

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“…Fibrinolysis with the clot breakdown is a normal response to tissue damage [5,7,13]. The molecular modeling of fibrinolysis shows a disaggregation of the fibers of fibrin by activated plasmin.…”

Section: Materials Science Forummentioning

confidence: 99%

“…Soon TXA inhibits the fibrin degradation [15,16]. Antifibrinolytic drug, such as TXA, can prevent early clot breakdown [13]. Tranexamic acid (TXA) seems to present a support action for coagulation already in progress [14].…”

Section: Materials Science Forummentioning

confidence: 99%

Osseointegration of Ti-30Ta Implants without Primary Stability: Effect of Tranexamic Acid

Capalbo

Louzada

Rangel

et al. 2016

MSF

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A large clot formed between the inside of the bony wall of the extraction socket and the immediate implant surface may have premature breakdown . Tranexamic acid (TXA) is fibrinolysis inhibitor and an analog of the amino acid lysine. In this paper the influence of tranexamic acid on the osseointegration of Ti-30Ta implants without primary stability was investigated. Were fabricated 32 implants of CP Titanium Grade 4 and 32 implants of Ti-30Ta alloy with dimensions of 2.1 x 2.8mm Ø. Bone defects of 2.5x3.2 mm Ø were created in right tibia of 64 Wistar male-rats using a small round bur. They were divided (n=16) into: Group I (CP-Ti machined implant), Group II (CP-Ti machined implant/ tranexamic acid), Group III (Ti-30Ta implant) and Group IV (Ti-30Ta implant/ tranexamic acid). The surgical defects of the Group II and Group IV were bathed with 20 ml of the tranexamic acid solution. The animals were euthanized at 45 days postoperative. In the right tibia of half each group (8 animals/8 tibiae) the maximum torque value necessary for manual removal of each implant was measured in Newton centimeters (Ncm). The right tibia of other half each group was subjected to non-decalcified histology processing (Stevenel's blue/Alizarin red). Data were analyzed statistically (Kruskal-Wallis Analyses) and demonstrated significant differences (P<0.05) among groups. The values of group I were significantly lower than group III and IV, but without significant difference than group II both removal torque and peri-implant bone healing. The results suggest that: a) peri-implant bone formation occurred more rapidly around the Ti-30Ta implant; b) tranexamic acid favored the stabilization of blood clot and bone formation around Ti-30Ta implants and not influenced bone formation around Ti-CP implants.

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Ácido tranexâmico no tratamento da hemorragia no trauma

Abstract: Ácido tranexâmico no tratamento da hemorragia no trauma Ácido tranexâmico no tratamento da hemorragia no trauma Ácido tranexâmico no tratamento da hemorragia no trauma Ácido tranexâmico no tratamento da hemorragia no trauma Ácido tranexâmico no tratamento da hemorragia no trauma

Cited by 14 publications

References 5 publications

Tranexamic Acid Action on Liver Regeneration After Partial Hepatectomy: Experimental Model in Rats

Tranexamic Acid Action on Liver Regeneration After Partial Hepatectomy: Experimental Model in Rats

Anemias em pacientes internados em um hospital de Teixeira Soares-PR / Anemia in patients admitted to a hospital in Teixeira Soares-PR

Osseointegration of Ti-30Ta Implants without Primary Stability: Effect of Tranexamic Acid

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