Efetividade do uso combinado de filme de ácido lático e tela de polipropileno na formação de aderências intraperitoneal: um modelo experimental em ratos

Lontra, Marcelo Bentancor; Bigolin, André Vicente; Costa, Ricardo Gonçalves da; Grossi, João Vicente Machado; Scalco, Priscila Pereira da Cunha; Roll, Sérgio; Cavazzola, Leandro Totti

doi:10.1590/s0100-69912010000500010

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…The use of polypropylene suture thread to fixate the mesh to the wall may explain the adhesion that is located closer to the periphery of the mesh. In the polypropylene group the adhesions occurred in a more distributed form throughout the area of the mesh, similarly to other studies 5 , 17 . All the animals in the polypropylene group had omental adhesions, but also small intestine and colon.…”

Section: Discussionsupporting

confidence: 87%

“…All the animals in the polypropylene group had omental adhesions, but also small intestine and colon. This finding is well described by many available studies 2 , 5 , 6 , 11 , 17 , 29 . The adhesions could be easily detached from the mesh in both groups.…”

Section: Discussionsupporting

confidence: 85%

“…There has been constant research on adhesion by score and analysis of barrier materials in the surgical literature 5 , 6 , 17 . In this variable, adhesion, there was no statistical difference between the meshes and the size effect was small.…”

Section: Discussionmentioning

confidence: 99%

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Peritoneal Adhesions Type I, Iii and Total Collagen on Polypropylene and Coated Polypropylene Meshes: Experimental Study in Rats

Rossi

Trindade

d'Acâmpora

et al. 2017

ABCD, arq. bras. cir. dig.

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Background: Hernia correction is a routinely performed treatment in surgical practice. The improvement of the operative technique and available materials certainly has been a great benefit to the quality of surgical results. The insertion of prostheses for hernia correction is well-founded in the literature, and has become the standard of treatment when this type of disease is discussed. Aim: To evaluate two available prostheses: the polypropylene and polypropylene coated ones in an experimental model. Methods: Seven prostheses of each kind were inserted into Wistar rats (Ratus norvegicus albinus) in the anterior abdominal wall of the animal in direct contact with the viscera. After 90 days follow-up were analyzed the intra-abdominal adhesions, and also performed immunohistochemical evaluation and videomorphometry of the total, type I and type III collagen. Histological analysis was also performed with hematoxylin-eosin to evaluate cell types present in each mesh. Results: At 90 days the adhesions were not different among the groups (p=0.335). Total collagen likewise was not statistically different (p=0.810). Statistically there was more type III collagen in the coated polypropylene group (p=0.039) while type I was not different among the prostheses (p=0.050). The lymphocytes were statistically more present in the polypropylene group (p=0.041). Conclusion: The coated prosthesis was not different from the polypropylene one regarding the adhesion. Total and type I collagen were not different among the groups, while type III collagen was more present on the coated mesh. There was a greater number of lymphocytes on the polypropylene mesh.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 85%

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Peritoneal Adhesions Type I, Iii and Total Collagen on Polypropylene and Coated Polypropylene Meshes: Experimental Study in Rats

Rossi

Trindade

d'Acâmpora

et al. 2017

ABCD, arq. bras. cir. dig.

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“…The degree of adhesions can be classified according to a pre-standardized table described in other studies (Table 1) 21 .…”

Section: Procedures Procedures Procedures Procedures Proceduresmentioning

confidence: 99%

Análise das aderências resultantes da fixação de telas cirúrgicas com selantes de fibrina e sutura: modelo experimental intraperitoneal

Montes¹,

Bigolin²,

Baú³

et al. 2012

Rev. Col. Bras. Cir.

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Biofilm Matrix Exoproteins Induce a Protective Immune Response against Staphylococcus aureus Biofilm Infection

et al. 2014

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The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there is an increasing interest in preventing the formation of S. aureus biofilms and developing efficient antibiofilm vaccines. Given the fact that during a biofilm-associated infection, the first primary interface between the host and the bacteria is the self-produced extracellular matrix, in this study we analyzed the potential of extracellular proteins found in the biofilm matrix to induce a protective immune response against S. aureus infections. By using proteomic approaches, we characterized the exoproteomes of exopolysaccharide-based and proteinbased biofilm matrices produced by two clinical S. aureus strains. Remarkably, results showed that independently of the nature of the biofilm matrix, a common core of secreted proteins is contained in both types of exoproteomes. Intradermal administration of an exoproteome extract of an exopolysaccharide-dependent biofilm induced a humoral immune response and elicited the production of interleukin 10 (IL-10) and IL-17 in mice. Antibodies against such an extract promoted opsonophagocytosis and killing of S. aureus. Immunization with the biofilm matrix exoproteome significantly reduced the number of bacterial cells inside a biofilm and on the surrounding tissue, using an in vivo model of mesh-associated biofilm infection. Furthermore, immunized mice also showed limited organ colonization by bacteria released from the matrix at the dispersive stage of the biofilm cycle. Altogether, these data illustrate the potential of biofilm matrix exoproteins as a promising candidate multivalent vaccine against S. aureus biofilm-associated infections.

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Efetividade do uso combinado de filme de ácido lático e tela de polipropileno na formação de aderências intraperitoneal: um modelo experimental em ratos

Abstract: The combined use of polypropylene mesh and lactic acid bioprotector showed similar results in relation to intraperitoneal adhesion formation when compared to the sole use of the same mesh.

Cited by 4 publications

References 22 publications

Peritoneal Adhesions Type I, Iii and Total Collagen on Polypropylene and Coated Polypropylene Meshes: Experimental Study in Rats

Peritoneal Adhesions Type I, Iii and Total Collagen on Polypropylene and Coated Polypropylene Meshes: Experimental Study in Rats

Análise das aderências resultantes da fixação de telas cirúrgicas com selantes de fibrina e sutura: modelo experimental intraperitoneal

Biofilm Matrix Exoproteins Induce a Protective Immune Response against Staphylococcus aureus Biofilm Infection

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