Abordagem reversa: novo paradigma no tratamento da metástase hepática sincrônica de câncer colorretal

Valadão, Marcus

doi:10.1590/s0100-69912010000500001

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Cited by 4 publications

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“…The management of liver metastasis often includes surgical removal, chemotherapy and other biological treatments. Different types of molecules, such as immunomodulating cytokines, have been adopted to treat liver metastasis 18–21. In the present study we demonstrated that IL-12 treatment could effectively decrease the formation of liver metastasis sites and the percentage of metastasis volume in the liver.…”

Section: Discussionsupporting

confidence: 55%

Interleukin-12 prevents colorectal cancer liver metastases in mice

Shen

Li²,

Cai³

et al. 2013

OTT

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Interleukin (IL)-12 has emerged to be a prospective molecule for antitumor therapies with many types of cancers. Here we examine the effect of IL-12 treatment in preventing the colorectal cancer liver metastasis in a mice model. At different doses, we found that IL-12 treatment decreased the formation of liver metastasis sites and the percentage of metastasis volume in the liver. Additionally, this treatment leads to improved survival function of mice after tumor cell transplantation. We believe that IL-12 based therapy provided a novel treatment to colorectal cancer patients suffering from liver metastasis.

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Section: Discussionsupporting

confidence: 55%