Malacoplaquia intestinal

Pulmonary malakoplakia associated with immunodeficiency by HTLV-1 and HIV

“…Malakoplakia is a rare chronic granulomatous inflammatory disease (1,10) , macroscopically reported as yellow-gray plates, composed of aggregates of histiocytes (7,10) , as first described in the bladder, in 1902, by Michaelis and Gutmann. Currently, intracellular basophilic inclusions, known as Michaelis-Gutmann bodies (MG bodies), found in von Hansemann histiocytes, are pathognomonic for malakoplakia (1,7,9) .…”

“…Currently, intracellular basophilic inclusions, known as Michaelis-Gutmann bodies (MG bodies), found in von Hansemann histiocytes, are pathognomonic for malakoplakia (1,7,9) . This shows bimodal …”

“…Within this prevail in descending order: bladder, ureter, pelvis, and renal parenchyma (1,3,6,10,11) . The gastrointestinal tract and retroperitoneal region are the secondary most affected sites (12%-15%) by the disease.…”

“…The most accepted theory holds that chronic bacterial infections in patients with chronic weakness or immunosuppression would cause a deficit of cyclic guanosine monophosphate (cGMP) in microtubule and defective macrophage, causing them to phagocyte bacteria, but, in contrast, they would be unable to digest them due to intra-lisosomal failure. This situation would lead to intracytoplasmic deposition of fragments from bacteria, iron, and calcium, which would form the MG bodies (1,3,6,9) . In support of this theory, many studies state that these inclusions represent intake and persistence of bacteria in macrophages (4,5) .…”

“…Some of these cells may contain amorphous, rounded cytoplasmic inclusions, with centers of concentric membranes, which are bacteria fragments with target or owl eye aspect, they are basophilic and PAS (periodic acid-Schiff) positives. Because they contain ferric salt and phosphate salt deposits, they are positive, respectively, to Pearls and Von Kossa, known as MG bodies (1,3,8,10,11) . It is also known, by the experience of most authors, that MG bodies are easily recognized by Papanicolaou, Diff-Quik, and hematoxylin-eosin staining (2) .…”