A simple spectrophotometric method for the determination of tetracycline and doxycycline in pharmaceutical formulations using chloramine-T

Rufino, José Luiz; Fernandes, Flávio Cesar Bedatty; Ruy, Mayara S.; Pezza, Helena Redigolo; Pezza, Leonardo

doi:10.1590/s0100-46702010000400018

Cited by 20 publications

(9 citation statements)

References 32 publications

(30 reference statements)

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“…The detection limit was determined to be 117 nM (52 µg/kg) and the linear region was between 0.2 µM and 6 µM. Compared to other methods reported for doxycycline detection, such as fluorescence (LOD: 110 nM; 49 µg/kg) [28], electrochemical (LOD: 43.5 µM; 19.3 mg/kg) [29] and spectrophotometric (LOD: 710 nM; 315 µg/kg) [30] sensors, our multifunctional FMIPs demonstrated comparable or higher sensitivity.…”

Section: Fluorescence Properties Of Feo X @Sio 2 -Fmipsmentioning

confidence: 85%

A multifunctional molecularly imprinted polymer-based biosensor for direct detection of doxycycline in food samples

Ashley

Feng

Sun

2018

Talanta

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In this study, we developed a new type of multifunctional molecularly imprinted polymer (MIP) composite as an all-in-one biosensor for the low-cost, rapid and sensitive detection of doxycycline in pig plasma. The MIP composite consisted of a magnetic core for ease of manipulation, and a shell of fluorescent MIPs for selective recognition of doxycycline. By simply incorporating a small amount of fluorescent monomer (fluorescein-O-acrylate), the fluorescent MIP layer was successfully grafted onto the magnetic core via a surface imprinting technique. The resultant MIP composites showed significant doxycycline-dependent fluorescence quenching in an aqueous environment. Good linearity ranging from 0.2 to 6 µM was achieved, and the limit of detection was determined to be 117 nM. The biosensor also showed good selectivity towards doxycycline when compared to other common antibiotic residues. The multifunctional MIP composites were used to directly extract doxycycline from spiked pig plasma samples and quantify the antibiotics based on the quenched fluorescence signals. Recoveries of doxycycline were found in the range of 88-107%.

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Section: Fluorescence Properties Of Feo X @Sio 2 -Fmipsmentioning

confidence: 85%

A multifunctional molecularly imprinted polymer-based biosensor for direct detection of doxycycline in food samples

Ashley

Feng

Sun

2018

Talanta

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“…Coulomb attraction holds oppositely charged ions together in solution in the ion-pair complex [ 56 ]. Some antibiotics have been analyzed using spectrophotometric methods including amoxicillin [ 40 ], azithromycin [ 41 , 57 ], tetracycline, doxycycline [ 58 ], and cefixime trihydrate [ 59 ]. They have also been used to analyze gentamicin sulfate [ 60 ], cefadroxil, ceftazidime, cefazolin sodium, cefoperazone sodium, cefaclor, cephaprin sodium, cefotaxime sodium, and cefuroxime sodium [ 61 ].…”

Section: Methods Used To Analyze Antibioticsmentioning

confidence: 99%

A Review of Methods for Removal of Ceftriaxone from Wastewater

Karungamye

Rugaika

Mtei

et al. 2022

JoX

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The presence of pharmaceuticals in surface water and wastewater poses a threat to public health and has significant effects on the ecosystem. Since most wastewater treatment plants are ineffective at removing molecules efficiently, some pharmaceuticals enter aquatic ecosystems, thus creating issues such as antibiotic resistance and toxicity. This review summarizes the methods used for the removal of ceftriaxone antibiotics from aquatic environments. Ceftriaxone is one of the most commonly prescribed antibiotics in many countries, including Tanzania. Ceftriaxone has been reported to be less or not degraded in traditional wastewater treatment of domestic sewage. This has piqued the interest of researchers in the monitoring and removal of ceftriaxone from wastewater. Its removal from aqueous systems has been studied using a variety of methods which include physical, biological, and chemical processes. As a result, information about ceftriaxone has been gathered from many sources with the searched themes being ceftriaxone in wastewater, ceftriaxone analysis, and ceftriaxone removal or degradation. The methods studied have been highlighted and the opportunities for future research have been described.

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“…The method was based on the formation of blue colored chromogen measured at λ max 770 nm due to reduction of tungstate and/or molybdate in Folin-Ciocalteu reagent by doxycycline in alkaline medium. [122] Rufino et al, [123] described a simple spectrophotometric method for the determination of doxycycline. The method was based on the reaction between the drug and chloramine T in alkaline medium; producing red color with maximum absorbance at λ max 525 nm.…”

Section: Spectrophotometric Methodsmentioning

confidence: 99%