New reagents for the spectrophotometric determination of ranitidine hydrochloride

Narayana, B.; Veena, K.; Ashwani, K.; Shetty, Divya N.

doi:10.1590/s0100-46702010000300010

Cited by 16 publications

(19 citation statements)

References 15 publications

(15 reference statements)

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“…For determination of low ranitidine concentrations spectrophotometric method, based on addition of ceric ammonium sulfate and dye crystal violet with measuring absorbance at 582 nm was applied (detection limit 0.1 mg/L (Narayana et al, 2010).…”

Section: Instrumentationmentioning

confidence: 99%

Characterization of a low cost Lagenaria vulgaris based carbon for ranitidine removal from aqueous solutions

Bojić

Momčilović

Milenković³

et al. 2017

Arabian Journal of Chemistry

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Practical aspects of Lagenaria vulgaris shell conversion to activated carbon were examined along with its use in ranitidine adsorption. Kinetics and isotherms of adsorption onto Lagenaria vulgaris carbon (LVC) were correlated to several theoretical adsorption models. The best fit was found in the case of Langmuir and pseudo-second-order model indicating monolayer adsorption. The influence of pH under kinetic study showed slightly hindered adsorption below pH 4. The optimal adsorbent dosage was set to 1 g/L. LVC was characterized by several complementary techniques, including wet chemical techniques such as Boehm's titrations and determination of pH PZC and pH of LVC, which revealed neutral nature of the adsorbent. N 2 sorptometry determined specific surface area of 665 m 2 /g and significant ratio of micropores in the sample with maximum wall's diameter of 2.2 nm. Fourier transform infrared spectroscopy (FTIR) confirmed the role of lignin and cellulose in the formation of the final LVC structure. Porous structure of the material was proved by using scanning electron microscopy. Preparation of LVC material drew attention as an easy and low-cost process for production of a highly efficient adsorbent which

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Section: Instrumentationmentioning

confidence: 99%

Characterization of a low cost Lagenaria vulgaris based carbon for ranitidine removal from aqueous solutions

Bojić

Momčilović

Milenković³

et al. 2017

Arabian Journal of Chemistry

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“…For these latter reasons, spectrophotometric methodologies, because of their inherent simplicity, low cost and wide availability were extensively proposed for R . HCl determination [19][20][21][22][23][24][25][26][27][28][29][30] . These methods are based on redox, coupling, charge-transfer complexation, and ion pair complexation reactions.…”

Section: Ranitidine N-(2-{[(5-dimethylamino)methyl]-2-furanyl}-methymentioning

confidence: 99%

Spectrophotometric Method for Ranitidine Determination in Drugs Using Rhodamine B

Moldovan¹,

Aboul‐Enein²

2012

J. Chil. Chem. Soc.

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A new spectrophotometric method has been developed for the determination of ranitidine hydrochloride (R . HCl) in bulk drug and in tablet formulation. The proposed method involves the addition of a measured excess of bromate-bromide reagent in hydrochloric acid medium to R . HCl, followed by determination of residual bromine by reacting with a fixed amount of Rhodamine B (RB) and measuring the absorbance at λ max =557 nm. Beer's law was found in the range of 0.3-3.2 μg ml -1 of R . HCl, with a good correlation coefficient (r=0.9997). The limits of detection and quantification were calculated to be 0.08 μg ml -1 and 0.24mg ml -1 , respectively. The different experimental parameters affecting the development and stability of the proposed method were carefully studied and optimized. The validity of the proposed method tested by analyzing the pure and pharmaceutical formulations and compared well with those obtained by the official method, demonstrated good accuracy and precision.

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“…Visible spectrophotometry may serve as an useful alternatives to many of the aforesaid 2 ISRN Spectroscopy sophisticated techniques, because of its cost effectiveness, ease of operation, sensitivity, fair accuracy and precision, and wide applicability. Narayana and Veena [21] developed two methods for the determination of FFH in bulk drug and in its tablet form. In their procedures, FFH was treated with a measured excess of chloramine-T (CAT), and the unreacted oxidant was reacted with malachite green or xylene cyanol FF, and the change in absorbance was measured at 615 or 612 nm.…”

Section: Introductionmentioning

confidence: 99%

Use of Alizarin Red S as an Ion-Pair Reagent for the Spectrophotometric Assay of Fexofenadine in Pharmaceuticals and in Spiked Human Urine

et al. 2012

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The present study describes two simple, rapid, selective, and cost-effective spectrophotometric methods for the determination of an antiallergic drug, fexofenadine hydrochloride (FFH), in bulk drug, tablets, and in spiked human urine. The first method (method A) is based on the formation of yellow-colored ion-pair complex between FFH and alizarin red S (AZS) in acid medium which was extracted into dichloromethane, and the absorbance was measured at 440 nm. The second method (method B) is based on the breaking of the yellow FFH-AZS ion-pair complex in alkaline medium followed by the measurement of the violet-colored free dye at 590 nm. Under the optimized conditions, Beer's law is obeyed over the concentration ranges of 0.4-12.0 and 0.2-3.5 μg mL −1 FFH for method A and method B, respectively, and the corresponding molar absorptivity values are 3.80 × 10 4 and 1.61 × 10 5 L mol −1 cm −1 . The Sandell's sensitivity, detection, and quantification limits are also reported. The proposed methods were successfully applied to the determination of FFH in pure drug and commercial tablets. The accuracy and reliability of the proposed methods were further established by recovery studies via standard addition technique.

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New reagents for the spectrophotometric determination of ranitidine hydrochloride

Cited by 16 publications

References 15 publications

Characterization of a low cost Lagenaria vulgaris based carbon for ranitidine removal from aqueous solutions

Characterization of a low cost Lagenaria vulgaris based carbon for ranitidine removal from aqueous solutions

Spectrophotometric Method for Ranitidine Determination in Drugs Using Rhodamine B

Use of Alizarin Red S as an Ion-Pair Reagent for the Spectrophotometric Assay of Fexofenadine in Pharmaceuticals and in Spiked Human Urine

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