Spectrophotometric determination of mosapride in pure and pharmaceutical preparations

Revanasiddappa, H. D.; Veena, M. A.

doi:10.1590/s0100-46702007000400010

Cited by 7 publications

(7 citation statements)

References 8 publications

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“…A stoichiometric ratio of 1:1 gave the maximum signal response which is indicative of the formation of a mono azo dye following coupling. This is consistent with the proposed chemical structure of the azo adduct formed as reported in a number of method development studies involving the use of chromotropic acid as the coupling agent for diazotised pharmaceutical agents (Abou-Attia, Issa, El-Reis, Aly, & El-Moety, 2002; Revanasiddappa and Veena, 2007;Darweesh, Al-Haidari, Mohammed, & Dikran, 2017). However, we disagree with the conclusion in these reports that the azo linkage is ortho to the hydroxyl group because in that case a 1:1 adduct is unlikely as two of such ortho positions exist in the coupling agent with both being chemically equivalent with little or no possibility of steric interference from each other.…”

Section: Stoichiometry and Reaction Mechanismsupporting

confidence: 87%

A new method for the microdetermination of Para-aminophenol in generic brands of paracetamol tablets

Adegoke

Thomas

Amao

et al. 2019

Arab Journal of Basic and Applied Sciences

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In Nigeria, paracetamol is readily available in several retail outlets where the conditions of storage can be poor leading to elevated levels of para-aminophenol (PAP), which is known to be nephrotoxic and hepatotoxic. However, the routine analysis of PAP is mostly by chromatographic separation which requires expensive instrumentation not often available in developing countries. The objective of this research was to develop a sensitive colorimetric method for the quantification of PAP in paracetamol. The method was based on the diazo coupling reaction between diazotised PAP and chromotropic acid. Various reaction parameters critical for optimal detector response were optimized. The validation of the new method was done following the determination of parameters including repeatability, reproducibility and selectivity using current ICH guidelines. The new method was also applied to the assay of PAP in 14 paracetamol tablet samples. The calibration was linear between 0.0297 and 0.2229 mg/mL at 470 nm with limits of detection and quantification of 0.0061 and 0.0185 mg/mL, respectively. The recovery was in the range of 95.96 and 102.21 while intra-and inter-day precisions at three different concentrations did not exceed 4.03%. The new method was successfully applied to quantify PAP in paracetamol with percent content varying from 0.14 to 0.21%w/w. A simple and reliable method for the quantification of PAP has been developed and successfully employed to report, for the first time, the presence of the degradation product at levels beyond the allowable limits in paracetamol dosage forms in Nigeria.

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Section: Stoichiometry and Reaction Mechanismsupporting

confidence: 87%

A new method for the microdetermination of Para-aminophenol in generic brands of paracetamol tablets

Adegoke

Thomas

Amao

et al. 2019

Arab Journal of Basic and Applied Sciences

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“…This was also consistent with the observation that only one spot was obtained in the TLC analysis of the azo adduct. Similar 1:1 ratios and mono azo products were reported in a number of studies in which chromotropic acid was employed as coupling agent with diazotizable drugs [32][33] .…”

Section: Stoichiometric Ratio and Mechanism Of Reactionsupporting

confidence: 73%

A new spectrophotometric method for the determination of gabapentin using chromotropic acid

Adegbolagun¹,

Thomas²,

Aiyenale³

et al. 2018

actapharm

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“…The coupling procedures vary somewhat, depending on the reactivity of the compounds involved. Some compounds will couple in acidic solution; other will couple in a very alkaline solution [10]. The more alkaline the solution, the faster the coupling reaction of diazonium compounds.…”

Section: Resultsmentioning

confidence: 99%

Validated spectophotometric methods for the assay of cinitapride hydrogen tartrate in pharmaceuticals

Kosaraju

Nageswara

2013

CI&CEQ

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Three simple, selective and rapid spectrophotometric methods have been established for the determination of cinitapride hydrogen tartrate (CHT) in pharmaceutical tablets. The proposed methods are based on the diazotization of CHT with sodium nitrite and hydrochloric acid, followed by coupling with resorcinol, 1-benzoylacetone and 8-hydroxyquinoline in alkaline medium for methods A, B and C respectively. The formed azo dyes are measured at 442, 465 and 552 nm for methods A, B and C respectively. The parameters that affect the reaction were carefully optimized. Under optimum conditions, Beer’s law is obeyed over the ranges 2.0-32.0, 1.0-24.0 and 1.0-20.0 μg. mL-1 for methods A, B, and C, respectively. The calculated molar absorptivity values are 1.2853 x104, 1.9624 x104 and 3.92 x104 L.mol-1.cm-1 for methods A, B and C, respectively. The results of the proposed procedures were validated statistically according to ICH guidelines. The proposed methods were successfully applied to the determination of CHT in Cintapro tablets without interference from common excipients encountered

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Spectrophotometric determination of mosapride in pure and pharmaceutical preparations

Cited by 7 publications

References 8 publications

A new method for the microdetermination of Para-aminophenol in generic brands of paracetamol tablets

A new method for the microdetermination of Para-aminophenol in generic brands of paracetamol tablets

A new spectrophotometric method for the determination of gabapentin using chromotropic acid

Validated spectophotometric methods for the assay of cinitapride hydrogen tartrate in pharmaceuticals

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