Clivagem dos ciclopaladados diméricos [Pd(dmba)(m-X)]2 (dmba = N,N-dimetilbenzilamina; X = Cl, N3, NCO) por tiouréia

Abstract

Ciclopaladados diméricos do tipo [Pd(dmba)(m-X)]2 (dmba = N,N-dimetilbenzilamina; X = Cl, N3, NCO) reagem com tiouréia (tu), à temperatura ambiente, resultando espécies mononucleares do tipo [Pd(dmba)(X)(tu)]. Todos os compostos foram caracterizados por análise elementar, espectroscopias no IV e de RMN de ¹H e com base nessas técnicas as estruturas, desses compostos, foram propostas. Os espectros de absorção no infravermelho mostraram que a coordenação da tiouréia, ao paládio, ocorre através do átomo de enxofre. O anel ciclometalado foi confirmado através da espectroscopia de RMN de ¹H.

Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2,N-dmba)(Br)(tu)] (dmba =N,N-dimethylbenzylamine, tu = thiourea)

“…Spectroscopic results of compound 1 have already been reported and discussed elsewhere [17]. Complex [Pd(C 2 ,N-dmba)(Br)(tu)] (2) was characterized by infrared (IR), 1 H-and 13 C{ 1 H} NMR spectroscopies as well as by single-crystal X-ray diffraction method.…”

“…The compound [Pd(C 2 ,N-dmba)(m-Br)] 2 was synthesized from [Pd(C 2 ,N-dmba)(m-Cl)] 2 by an anion exchange reaction. Complex [Pd(C 2 ,N-dmba)(Cl)(tu)] (1) was obtained according to the method described in the literature [17]. The reaction between the cyclopalladated compound [Pd(C 2 ,Ndmba)(m-Br)] 2 and tu in the 1:2 molar ratio readily occurred, leading to the new complex [Pd(C 2 ,N-dmba)(Br)(tu)] (2), Fig.…”

“…Our interest in palladium (II) compounds bearing thiourea typeligands is focusing on preparing new species with promising biological activities [16,17]. We have developed a procedure for the synthesis of mononuclear cyclopalladated compounds of general formulae [Pd(C 2 ,N-dmba)(X)(tu)] (X ¼ Cl, N 3 , NCO) from cleavage reactions of [Pd(C 2 ,N-dmba)(m-X)] 2 with thiourea [17].…”

“…We have developed a procedure for the synthesis of mononuclear cyclopalladated compounds of general formulae [Pd(C 2 ,N-dmba)(X)(tu)] (X ¼ Cl, N 3 , NCO) from cleavage reactions of [Pd(C 2 ,N-dmba)(m-X)] 2 with thiourea [17].…”

“…In order to present some of our recent contributions in the coordination chemistry of palladium (II) complexes containing halides and pseudohalides as coligands [17][18][19], in this report we have evaluated the in vitro cytotoxic potential (IC 50 ) of the compounds [Pd(C 2 ,Ndmba)(Cl)(tu)] (1) and [Pd(C 2 ,N-dmba)(Br)(tu)] (2), (dmba ¼ N,Ndimethylbenzylamine, tu ¼ thiourea) against the LM3 and LP07 murine tumor cell lines, as well as their minimal inhibitory concentration (MIC) values against M. tuberculosis. In addition, this work also describes the synthesis, spectroscopic and structural characterization of [Pd(C 2 ,N-dmba)(Br)(tu)] (2).…”