Flavonoides e outros compostos isolados de Mimosa artemisiana Heringer e Paula

Nascimento, Ildomar Alves do; Braz‐Filho, Raimundo; Carvalho, Mário Geraldo de; Mathias, Lêda; Fonseca, Fábio de Alcântara

doi:10.1590/s0100-40422012001100010

Cited by 11 publications

(10 citation statements)

References 21 publications

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“…Steroid compounds identified in the hexane fraction of M. caesalpiniifolia showed a similar distribution pattern to that observed in M. artemisiana , including the presence of stenols and stenones [6]. The steroids identified were subdivided into four classes: non-oxygenated steroids (0.10%), stenols (9.46%), stenones (6.08%) and diketosteroids (0.36%).…”

Section: Resultsmentioning

confidence: 79%

“…Mimosa species are rich in polyphenol compounds such as flavonoids (e.g., flavones, flavonols), lignans and other phytochemicals, including alkaloids, terpenoids, steroids and saponins [4,5,6,7,8]. In pharmacological investigations, Mimosa species are mainly characterised by their antioxidant potential [4,9] and antimicrobial activity [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Assessing Chemical Constituents of Mimosa caesalpiniifolia Stem Bark: Possible Bioactive Components Accountable for the Cytotoxic Effect of M. caesalpiniifolia on Human Tumour Cell Lines

et al. 2015

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Mimosa caesalpiniifolia is a native plant of the Brazilian northeast, and few studies have investigated its chemical composition and biological significance. This work describes the identification of the first chemical constituents in the ethanolic extract and fractions of M. caesalpiniifolia stem bark based on NMR, GC-qMS and HRMS analyses, as well as an assessment of their cytotoxic activity. GC-qMS analysis showed fatty acid derivatives, triterpenes and steroid substances and confirmed the identity of the chemical compounds isolated from the hexane fraction. Metabolite biodiversity in M. caesalpiniifolia stem bark revealed the differentiated accumulation of pentacyclic triterpenic acids, with a high content of betulinic acid and minor amounts of 3-oxo and 3β-acetoxy derivatives. OPEN ACCESSMolecules 2015, 20 4205Bioactive analysis based on total phenolic and flavonoid content showed a high amount of these compounds in the ethanolic extract, and ESI-(−)-LTQ-Orbitrap-MS identified caffeoyl hexose at high intensity, as well as the presence of phenolic acids and flavonoids. Furthermore, the evaluation of the ethanolic extract and fractions, including betulinic acid, against colon (HCT-116), ovarian (OVCAR-8) and glioblastoma (SF-295) tumour cell lines showed that the crude extract, hexane and dichloromethane fractions possessed moderate to high inhibitory activity, which may be related to the abundance of betulinic acid. The phytochemical and biological study of M. caesalpiniifolia stem bark thus revealed a new alternative source of antitumour compounds, possibly made effective by the presence of betulinic acid and by chemical co-synergism with other compounds.

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Section: Resultsmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Assessing Chemical Constituents of Mimosa caesalpiniifolia Stem Bark: Possible Bioactive Components Accountable for the Cytotoxic Effect of M. caesalpiniifolia on Human Tumour Cell Lines

et al. 2015

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“…The Mimosa genus has significant economic status in the cosmetic industry [ 23 ]. Phytochemical studies of this genus revealed the presence of flavonoids, steroids, saponins, alkaloids, coumarins, tannins [ 24 , 25 ] and terpenoids [ 26 ]. The genus Mimosa showed several pharmacological activities, such as antiseptic, antimicrobial [ 27 , 28 ], antidiabetic [ 29 , 30 ], antihistamic [ 31 ], antioxidants [ 32 , 33 , 34 , 35 , 36 , 37 ], anticonvulsant [ 38 ], antigout [ 39 ], antispasmolytic [ 40 ], anti-inflammatory [ 41 , 42 , 43 ], antinociceptive [ 44 , 45 ], antiulcer [ 43 ], antifertility [ 46 ], antimalarial [ 47 ], antiparasitic [ 48 ], wound healing [ 49 ], anticancer [ 50 , 51 ], antidepressant [ 52 ], antidiarrheal [ 53 , 54 ], hypolipidemic [ 55 , 56 ], hepatoprotective [ 57 ], antivenom [ 43 ], antiproliferative [ 58 ], antiviral [ 59 ] and aphrodisiac [ 60 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemistry and Diverse Pharmacology of Genus Mimosa: A Review

et al. 2022

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The genus Mimosa belongs to the Fabaceae family and comprises almost 400 species of herbs, shrubs and ornamental trees. The genus Mimosa is found all over the tropics and subtropics of Asia, Africa, South America, North America and Australia. Traditionally, this genus has been popular for the treatment of jaundice, diarrhea, fever, toothache, wound healing, asthma, leprosy, vaginal and urinary complaints, skin diseases, piles, gastrointestinal disorders, small pox, hepatitis, tumor, HIV, ulcers and ringworm. The review covered literature available from 1959 to 2020 collected from books, scientific journals and electronic searches, such as Science Direct, Web of Science and Google scholar. Various keywords, such as Mimosa, secondary metabolites, medicines, phytochemicals and pharmacological values, were used for the data search. The Mimosa species are acknowledged to be an essential source of secondary metabolites with a wide-ranging biological functions, and up until now, 145 compounds have been isolated from this genus. Pharmacological studies showed that isolated compounds possess significant potential, such as antiprotozoal, antimicrobial, antiviral, antioxidant, and antiproliferative as well as cytotoxic activities. Alkaloids, chalcones, flavonoids, indoles, terpenes, terpenoids, saponins, steroids, amino acids, glycosides, flavanols, phenols, lignoids, polysaccharides, lignins, salts and fatty esters have been isolated from this genus. This review focused on the medicinal aspects of the Mimosa species and may provide a comprehensive understanding of the prospective of this genus as a foundation of medicine, supplement and nourishment. The plants of this genus could be a potential source of medicines in the near future.

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“…DFMC did not produce hemolysis and showed higher potential as a cytotoxic agent than betulinic acid for the SF-295 and HL-60 lines [20,36], corroborating the findings described here for S180 cells. Phytochemical investigation of extracts from Mimosa species revealed the existence of terpenes, flavonoids, steroids, phenols (especially tannins), and fatty acid derivatives in different parts of the plant (leaves, fruits, flowers, branches, and stem bark) [36][37][38][39][40], mainly betulinic acid, lupeol, phytol, lactic acid, α-tocopherol, stigmasterol, β-sitosterol, sitostenone, and stigmasta-4,22-dien-3-one, which had been identified in dichloromethane, ethanolic, and hexane fractions of leaves and barks from M. caesalpiniifolia [15,36,40], suggesting that the antiproliferative potential of DFMC may be attributed, at least in part, to its chemopreventive action. In this context, Silva et al [15] stated the scavenger activity of M. caesalpiniifolia extracts, whose presence of phenolic compounds was confirmed by ultraviolet-visible spectroscopy and thin-layer chromatography.…”

Section: Discussionmentioning

confidence: 99%

Chemotherapeutic and Safety Profile of a Fraction from Mimosa caesalpiniifolia Stem Bark

Ferreira

Drumond

Silva

et al. 2021

Journal of Oncology

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Mimosa caesalpiniifolia (Fabaceae) is used by Brazilian people to treat hypertension, bronchitis, and skin infections. Herein, we evaluated the antiproliferative action of the dichloromethane fraction from M. caesalpiniifolia (DFMC) stem bark on murine tumor cells and the in vivo toxicogenetic profile. Initially, the cytotoxic activity of DFMC on primary cultures of Sarcoma 180 (S180) cells by Alamar Blue, trypan, and cytokinesis block micronucleus (CBMN) assays was assessed after 72 h of exposure, followed by the treatment of S180-bearing Swiss mice for 7 days, physiological investigations, and DNA/chromosomal damage. DFMC and betulinic acid revealed similar in vitro antiproliferative action on S180 cells and induced a reduction in viable cells, induced a reduction in viable cells and caused the emergence of bridges, buds, and morphological features of apoptosis and necrosis. S180-transplanted mice treated with DFMC (50 and 100 mg/kg/day), a betulinic acid-rich dichloromethane, showed for the first time in vivo tumor growth reduction (64.8 and 80.0%) and poorer peri- and intratumor quantities of vessels. Such antiproliferative action was associated with detectible side effects (loss of weight, reduction of spleen, lymphocytopenia, and neutrophilia and increasing of GOT and micronucleus in bone marrow), but preclinical general anticancer properties of the DFMC were not threatened by toxicological effects, and these biomedical discoveries validate the ethnopharmacological reputation of Mimosa species as emerging phytotherapy sources of lead molecules.

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Flavonoides e outros compostos isolados de Mimosa artemisiana Heringer e Paula

Cited by 11 publications

References 21 publications

Assessing Chemical Constituents of Mimosa caesalpiniifolia Stem Bark: Possible Bioactive Components Accountable for the Cytotoxic Effect of M. caesalpiniifolia on Human Tumour Cell Lines

Assessing Chemical Constituents of Mimosa caesalpiniifolia Stem Bark: Possible Bioactive Components Accountable for the Cytotoxic Effect of M. caesalpiniifolia on Human Tumour Cell Lines

Phytochemistry and Diverse Pharmacology of Genus Mimosa: A Review

Chemotherapeutic and Safety Profile of a Fraction from Mimosa caesalpiniifolia Stem Bark

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