A comparative study of hydroxyapatite nanoparticles synthesized by different routes

Abstract

In this study, bioactive hydroxyapatite nanoparticles were prepared by two different methods: wet chemical precipitation and biomimetic precipitation. The aim was to evaluate the morphology, particle-size, crystallinity and phases of the powders obtained by traditional wet chemical precipitation and the novel biomimetic precipitation using a supersaturated calcium solution. The nanoparticles were investigated by transmission electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction. The results revealed that the nanoparticles were formed by hydroxyapatite with a high crystallinity and controlled morphology. Additionally, it was found that the shape and size of the nanoparticles can be modified with each preparation method.

Characterization, drug loading and antibacterial activity of nanohydroxyapatite/polycaprolactone (nHA/PCL) electrospun membrane

“…A previous study shows that the hydroxyl group decreases when carbonate content increases (Rehman and Bonfield 1997). The spectrum shows the characteristic of nHA where the intense peak of 1021 cm -1 was associated with PO 4 3-antisymmetric stretching mode (Paz et al 2012). The 961 cm -1 peak corresponds to the PO 4 3--derived bands (Wang et al 2010).…”

Comparison of Naturally and Synthetically Derived Hydroxyapatite Powders

“…In the wet chemical precipitation technique, Ca(OH) 2 (calcium hydroxide, Sigma-Aldrich, ACS reagent, ≥ 95%) was used as the calcium source while H 3 PO 4 (phosphoric acid, Sigma-Aldrich, ACS reagent, ≥ 85 wt% in H 2 O) is the phosphorus source [4][5][6][7][8]. Since it is an acid-base process, the experimental procedure relies on adding the acid solution to the alkaline suspension dropwise with a rapid or slow addition rate at three different reaction temperatures, i.e.…”

“…room temperature, 50-60 (55) starting material solutions were determined by considering the Ca/P molar ratio of the product which is 1.67 for stoichiometric HA and the reaction between the precursors is stated in Eq. (1) [4][5][6][7][8]. The steps that were carried out during the wet chemical precipitation method can be shortly explained as: first, the acid-base reaction between Ca(OH) 2 • C/min heating rate to achieve well-crystallized HA powders.…”

“…Among these procedures wet chemical precipitation technique emerges as the most common process to synthesize HA powders owing to its advantages such as being a simple method, requiring inexpensive starting materials and working at low reaction temperatures [2][3][4][5][6][7]. Several parameters influence the results of the acid-alkaline reaction and in this research, acid reactant addition rate and reaction temperature factors were studied.…”

“…Several parameters influence the results of the acid-alkaline reaction and in this research, acid reactant addition rate and reaction temperature factors were studied. Reaction temperature has a role in determining the resultant particle size and shape of the obtained HA powders while acid addition rate is responsible * corresponding author; e-mail: azade.yelten@istanbul.edu.tr for the well-crystallization and growth of the HA particles [4][5][6][7][8]. Natural sources such as bovine bones, egg shells, coral reefs, etc.…”