Development of a simple UV-spectrophotometric method for the determination of lansoprazole and study of its degradation profile

Okram, Zenita Devi; Basavaiah, K.; Jagannathamurthy, Ramesh Pavagada; Basavaiah, Vinay Kanakapura

doi:10.1590/s0100-40422012000200027

Cited by 8 publications

(11 citation statements)

References 25 publications

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“…The percent EE and DL were calculated as follows: EE (%) = (amount of drug entrapped in cochleates or liposomes/total amount of the drug initially added) Â 100; DL (μg/mL) = amount of drug entrapped in cochleates or liposomes/total amount of lipid. 7,13 Analysis of LSP was carried out using high-performance liquid chromatography (HPLC) as previously reported. 14 The isocratic mobile phase consisted of 10 mM phosphate buffer and methanol (45:55 vol/vol), then LSP detection was achieved at 285 nm.…”

Section: Methodsmentioning

confidence: 99%

“…6 As shown in Figure 1, LSP has an inherent sulfoxide group and reduction of this group takes place in exposure to acidic environment, resulting in degradation of LSP. 7 Without the protection via enteric coating, LSP is degraded very rapidly under acidic environments, while stable in neutral and alkaline conditions. 6 With this regard, strategies to protect LSP from the destructive effects of gastric acid are necessary.…”

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confidence: 99%

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Cochleate Formulation Enhances the Stability of Lansoprazole in Acidic Condition

Goo

Jin

Kim

et al. 2021

Bulletin Korean Chem Soc

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Lansoprazole (LSP)-loaded cochleates were developed using dimyristoyl phosphatidylcholine (DMPC) and cholesterol in the presence or absence of dicetyl phosphate (DCP). Cochleates containing DCP exhibited unique cylindrical morphologies, resulting in improved LSP loading and enhanced stability in an acidic environment. Thus, we suggest that the use of negatively charged components, such as DCP, is needed to formulate cochleates using a neutrally charged lipid such as DMPC.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

Cochleate Formulation Enhances the Stability of Lansoprazole in Acidic Condition

Goo

Jin

Kim

et al. 2021

Bulletin Korean Chem Soc

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“…The LPZ content was determined by weighing a specified amount of the LPZ-NCT cocrystals in a volumetric flask, dissolving it in methanol, and filling it to the desired volume with double-distilled water. The samples were then assayed using an ultraviolet-visible (UV-VIS) spectrophotometer at a wavelength of 283 nm [12].…”

Section: Determination Of Lpz Contentmentioning

confidence: 99%

Dissolution Enhancement of Lansoprazole Using Cocrystallization

2020

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Objective: Lansoprazole (LPZ) is a Biopharmaceutics Classification System Class II drug. It has low solubility and high permeability, so its rate ofdissolution is a rate-limiting step for drug absorption. This study aimed to improve the dissolution rate of LPZ by forming cocrystals, using nicotinamide(NCT) as the conformer.Methods: Cocrystals of LPZ were produced using the solvent evaporation and solvent-drop grinding methods with a molar ratio of 1:1 and 1:2.The cocrystals were characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), and differential scanningcalorimetry (DSC). The solubility and dissolution of the LPZ cocrystals were examined in distilled water.Results: FTIR was used to confirm the formation of hydrogen bonds between LPZ and NCT. DSC and XRD studies showed the formation of crystalsfrom cocrystals and a decrease of the melting point of the cocrystals. The dissolution study revealed that the cocrystals could increase the LPZdissolution rate by up to 8.4-fold compared with pure LPZ.Conclusion: LPZ cocrystal formation with NCT was successful in increasing the dissolution rate of LPZ.

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“…The mass detector was operated in the electron-impact ionization mode (ionization energy, 70 eV). Molecular ion peaks were identified and possible structures were drawn on the basis of already reported data on decomposition pattern/chemical reactions of functional groups in OXCPM (14)(15)(16)(17)(18)(19).…”

Section: Identification Of Degradation Productsmentioning

confidence: 99%

Reverse-Phase Chromatographic Determination and Intrinsic Stability Behavior of 5-[(4-Chlorophenoxy)Methyl]-1,3,4-Oxadiazole-2-Thiol

et al. 2018

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The study describes the development and preliminary validation of a simple reverse-phase chromatographic method for determination of a novel drug candidate, 5-[(4-chlorophenoxy) methyl]-1,3,4-oxadiazole-2-thiol (OXCPM), in bulk and stressed solution, in order to find out the intrinsic stability behavior of the compound. Isocratic elution was carried out at a flow rate of 1.0 mL min-1 through a Promosil C18 column maintained at 25 °C, using the mobile phase comprising acetonitrile and aqueous o-H3PO4 (pH 2.67) (1:1, V/V). Detection was performed at 258 nm. The response of the detector was linear in a concentration range of 1.25-50.00 μg mL-1 with the correlation coefficient of 0.9996 ± 0.0001. Cumulative intra-day, inter-day and inter-instrument accuracy (99.5 ± 1.0, 100.2 ± 1.0 and 100.3 ± 0.4 %, resp.) with RSD less than 5 % indicated that the method was accurate and precise. The resolution and selectivity factor (>2 and >1, resp.), particularly in copper metal- and dry-heat-stress solutions, depicted the selectivity of the method. OXCPM remained stable under hydrolytic (acidic and neutral pH, ≤ 37 °C), photolytic and moist heat stress conditions. Under alkaline conditions (hydrolytic and photolytic), polar products were formed that eluted very fast through the column (tR < 3.75 min). At room temperature, the compound was susceptible to oxidation by hydrogen peroxide and transition metals. The ionogram of most of the stress solutions indicated the presence of a product having m/z 256, which might be a result of N- or Smethylation or -SH oxidation. The results of the study indicate that the method is selective, sensitive and suitable to be used for determination of OXCPM in bulk and under stress conditions.

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Development of a simple UV-spectrophotometric method for the determination of lansoprazole and study of its degradation profile

Cited by 8 publications

References 25 publications

Cochleate Formulation Enhances the Stability of Lansoprazole in Acidic Condition

Cochleate Formulation Enhances the Stability of Lansoprazole in Acidic Condition

Dissolution Enhancement of Lansoprazole Using Cocrystallization

Reverse-Phase Chromatographic Determination and Intrinsic Stability Behavior of 5-[(4-Chlorophenoxy)Methyl]-1,3,4-Oxadiazole-2-Thiol

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