Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries

Costa, Vicente Carlos de Oliveira; Tavares, Josean Fechine; Queiroga, Cinthia S.; Castello-Branco, Marianna V. S.; Diniz, Margareth F. F. Melo; Lima, Carolina Uchôa G. B. de; Santos, Bárbara Viviana de Oliveira; Pita, João Carlos Lima Rodrigues; Silva, Marcelo Sobral da; Sette, Ivana Maria Fechine

doi:10.1590/s0100-40422012000100025

Cited by 9 publications

(2 citation statements)

References 11 publications

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“…From 2 to 9 m in height, its tree has elliptical to ovate leaves, with yellow, orange, or red apocarpous fruits, its flowering and fruiting ranges from November to April [ 47 ]. Bananinha is indicated in traditional medicine for the treatment of inflammation and tumors [ 48 ], and for its larvicidal potential [ 49 ], as well as its modulating effect on bacterial resistance to norfloxacin, in addition to a considerable antitumor effect in vivo [ 50 ]. The phytochemical study points to the presence of aporphine and tetrahydro-protoberberine alkaloids, in addition to acetogenins and a xanthone [ 51 ].…”

Section: Introductionmentioning

confidence: 99%

An Integrative Approach to the Flavonoid Profile in Some Plants’ Parts of the Annona Genus

Ramos

Mazzinghy

Correia

et al. 2022

Plants

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The Annonaceae family is widely distributed in subtropical and tropical regions. Several species of this family are known for their pharmacological and beneficial properties to human health, mainly attributed to flavonoids. The objective of this work was to carry out an integrative review in order to identify the main flavonoids found in some plant parts belonging to the Annona genus: araticum tree (Annona crassiflora Mart.), graviola tree (Annona muricata), atemoya tree (Annona cherimolia Mill × Annona squamosa L.), pinha tree (Annona squamosa), bananinha tree (Annona leptopetala), and marolinho tree (Annona coriacea). Only articles published between the years 2016 to 2021 that answered the guiding question were considered, in order to obtain recent data. Then, search strategies were designated for each database used: Science Direct, CAPES Periodicals, and Scielo. Most of the studies retrieved from the databases are related to fruits. The results showed that the number of flavonoids identified varies according to the analytical methodology used to identify and quantify the compounds. Quercetin was the most commonly found compound in all fruits of the Annona genus studied, and epicatechin, rutin, and kaempferol were also found to a lesser extent. The presence of these compounds in Annona makes the fruit promising, with potential applicability in the pharmaceutical and food industry.

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Section: Introductionmentioning

confidence: 99%

An Integrative Approach to the Flavonoid Profile in Some Plants’ Parts of the Annona Genus

Ramos

Mazzinghy

Correia

et al. 2022

Plants

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“…Among these, we highlight acetogenins, alkaloids, and lignans ( Figueiredo et al , 1999 ; Reyes et al , 2002 ). Alkaloids of the Annonaceae species have been isolated and evaluated for their medicinal properties, showing antibacterial modulation ( Costa et al , 2013 ), antiplasmodial ( Osorio et al , 2006 ) and antileishmanial ( Vila-Nova et al , 2011 ) activities, and tumor cell cytotoxicity ( Costa et al , 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of <italic>Anonna mucosa</italic> (Jacq.) grown <italic>in vivo</italic> and obtained by <italic>in vitro</italic>culture

Barboza¹,

Ferreira²,

Ignácio³

et al. 2015

Braz. J. Microbiol.

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Brazilian flora includes numerous species of medicinal importance that can be used to develop new drugs. Plant tissue culture offers strategies for conservation and use of these species allowing continuous production of plants and bioactive substances. Annona mucosa has produced substances such as acetogenins and alkaloids that exhibit antimicrobial activities. The widespread use of antibiotics has led to an increase in multidrug-resistant bacteria, which represents a serious risk of infection. In view of this problem, the aim of this work was to evaluate the antibacterial potential of extracts of A. mucosa obtained by in vitro techniques and also cultured under in vivo conditions. Segments from seedlings were inoculated onto different culture media containing the auxin picloram and the cytokinin kinetin at different concentrations. The calluses obtained were used to produce cell suspension cultures. The materials were subjected to methanol extraction and subsequent fractionation in hexane and dichloromethane. The antimicrobial activity against 20 strains of clinical relevance was evaluated by the macrodilution method at minimum inhibitory and minimum bactericidal concentrations. The extracts showed selective antimicrobial activity, inhibiting the growth of Streptococcus pyogenes and Bacillus thuringiensis at different concentrations. The plant tissue culture methods produced plant materials with antibacterial properties, as well as in vivo grown plants. The antibacterial activity of material obtained through biotechnological procedures of A. mucosa is reported here for the first time.

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Hexane partition from Annona crassiflora Mart. promotes cytotoxity and apoptosis on human cervical cancer cell lines

et al. 2018

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Cervical cancer is the third most commonly diagnosed tumor type and the fourth cause of cancer-related death in females. Therapeutic options for cervical cancer patients remain very limited. Annona crassiflora Mart. is used in traditional medicine as antimicrobial and antineoplastic agent. However, little is known about its antitumoral properties. In this study the antineoplastic effect of crude extract and derived partitions from A. crassiflora Mart in cervical cancer cell lines was evaluated. The crude extract significantly alters cell viability of cervical cancer cell lines as well as proliferation and migration, and induces cell death in SiHa cells. Yet, the combination of the crude extract with cisplatin leads to antagonistic effect. Importantly, the hexane partition derived from the crude extract presented cytotoxic effect both in vitro and in vivo, and initiates cell responses, such as DNA damage (H2AX activity), apoptosis via intrinsic pathway (cleavage of caspase-9, caspase-3, poly (ADP-ribose) polymerase (PARP) and mitochondrial membrane depolarization) and decreased p21 expression by ubiquitin proteasome pathway. Concluding, this work shows that hexane partition triggers several biological responses such as DNA damage and apoptosis, by intrinsic pathways, and was also able to promote a direct decrease in tumor perimeter in vivo providing a basis for further investigation on its antineoplastic activity on cervical cancer.

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Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries

Cited by 9 publications

References 11 publications

An Integrative Approach to the Flavonoid Profile in Some Plants’ Parts of the Annona Genus

An Integrative Approach to the Flavonoid Profile in Some Plants’ Parts of the Annona Genus

Antimicrobial activity of <italic>Anonna mucosa</italic> (Jacq.) grown <italic>in vivo</italic> and obtained by <italic>in vitro</italic>culture

Hexane partition from Annona crassiflora Mart. promotes cytotoxity and apoptosis on human cervical cancer cell lines

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