Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms

Abstract

Recebido em 26/10/10; aceito em 30/1/11; publicado na web em 1/4/11 Three simple, sensitive, economical and reproducible spectrophotometric methods (A, B and C) are described for determination of mesalamine in pure drug as well as in tablet dosage forms. Method A is based on the reduction of tungstate and/or molybdate in Folin Ciocalteu's reagent; method B describes the reaction between the diazotized drug and α-naphthol and method C is based on the reaction of the drug with vanillin, in acidic medium. Under optimum conditions, mesalamine could be quantified in the concentration ranges, 1-30, 1-15 and 2-30 µg mL -1 by method A, B and C, respectively. All the methods have been applied to the determination of mesalamine in tablet dosage forms. Results of analysis are validated statistically.

Electrochemical determination of mesalazine by using graphene oxide coated with a molecularly imprinted sol–gel

“…Several analytical methods have been used for the analysis of ASA in real samples, such as high performance liquid chromatography (HPLC) combined with ultra-violet 2 and electrochemical detections, 3,4 micellar electrokinetic chromatography, 5 spectrophotometry, [6][7][8] uorescence spectroscopy, 9,10 liquid chromatography (LC), 11 LC-mass spectrometry 12,13 and capillary electrophoresis. 14 However, these methods are time consuming and require sample preparation processes and expensive equipment.…”