Liquid-phase microextraction using the microfluidic chip for the extraction of mesalazine from water and biological samples

Parvizi, Fatemeh; Parvareh, Arsalan; Heydari, Rouhollah

doi:10.1016/j.microc.2022.107752

Cited by 14 publications

(1 citation statement)

References 30 publications

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“…It is thought to have a beneficial anti-inflammatory action via increased expression of peroxisome proliferator-activated receptors in gastrointestinal epithelial cells [3]. Different analytical techniques were reported in the literature for the MES determination, including spectrofluorometry [4], high-pressure liquid chromatography (HPLC) [5], microfluidic devicebased liquid phase microextraction-HPLC [6], cyclic voltammetry [7], liquid chromatographymass spectroscopy [8], FIA [9], and spectrophotometry [10][11][12][13][14][15]. Due to their simplicity, excellent reproducibility, and inexpensive instrumentation costs, flowinjection analysis (FIA) approaches have attracted a lot of interest and are widely used.…”

Section: Introductionmentioning

confidence: 99%

Normal and Reverse Flow Injection Analysis Methods for Estimation of Mesalazine in Pharmaceutical Dosage Forms

Hasan,

Hadi

2023

IHJPAS

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Determining the actual amounts of active ingredients in various pharmaceutical commercial forms is still receiving a lot of attention. Two flow injection analysis (FIA) methods were suggested for determination of mesalazine (MES) in pharmaceutical forms. Normal and reverse FIA systems (nFIA and rFIA) combined with UV-Vis spectrophotometric technique were used for the analysis. The methods involved using two mods of FIA systems for measuring a colored product result from coupling of MES with 2,2'-dihydroxybiphenyl after oxidized with sodium periodate in alkaline medium. The absorbance of the red colored dye was measured at maximum wavelength of 500 nm. The calibration graphs for MES were linear in the ranges 2.5-200 and 0.5-60 µg/mL with RSD of best than 3% for both methods respectively. Also the limits of detection were 1.2 and 0.2 µg/mL and limits of quantitation were 3.6 and 0.7 µg/mL of MSL for nFIA and rFIA systems respectively. All physical and chemical conditions of flow systems such as flow rate, reaction coil length and reagent concentrations were carefully studied. The proposed methods were applied for determining MES in four commercial tablets without any interferences.

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