UV derivative spectrophotometric method for determination of estradiol valerate in tablets

Abstract

Recebido em 24/8/09; aceito em 12/11/09; publicado na web em 12/3/10 A derivative UV spectrophotometric method for determination of estradiol valerate in tablets was validated. The parameters specificity, linearity, precision, accuracy, limit of detection and limit of quantitation were studied according to validation guidelines. The first-order derivative spectra were obtained at N = 5, ∆λ = 4.0 nm, and determinations were made at 270 nm. The method showed specificity and linearity in the concentration range of 0.20 to 0.40 mg mL -1. The intra and interday precision data demonstrated the method has good reproducibility. Accuracy was also evaluated and results were satisfactory. The proposed method was successfully applied to a pharmaceutical formulation.

Derivative spectrophotometric method for determination of acyclovir in polymeric nanoparticles

“…Several applications have been found in many areas of analysis, especially in pharmaceutical. [19][20][21] Some methods employing DS were reported to the quantification of acyclovir (9-[2-hydroxyethoxymethyl]-9H-guanine, ACV) ( Figure 1) in order to quantify this drug in pharmaceutical dosage forms, such as injections and creams 22 or in the presence of guanine, its main impurity. 23 Nevertheless, according to our knowledge, there are no reports concerning the quantification of ACV in PACA nanoparticles by this technique.…”

Temperature-Driven Isosymmetric Reversible Phase Transition of the Hormone Estradiol 17β Valerate

“…There are many pharmaceutical products containing E2 in association with progestagen, such as E2V plus dienogest (DNG), used to enhance the effectiveness in preventing pregnancy, once natural E2 causes poor cycle control. In this way, concerning E2V, the literature reports several methods to determine this active pharmaceutical ingredient (API), most of them describing it in association with other hormones, for quality control of this drug. − …”

Chemiluminescence behavior of CdTe-hydrogen peroxide enhanced by sodium hypochlorite and sensitized sensing of estrogens

“…Estrogens have been detected with some analytical procedures, including high-performance liquid chromatography [ 4 - 9 ], UV derivative spectrophotometric method [ 10 ], gas chromatography (GC)-mass spectrometry (MS) analytical method [ 11 ], and capillary electrophoresis [ 12 ]. Semiconductor nanocrystals have been widely used as fluorescence biological probes [ 13 ], donors or acceptors of fluorescence resonance energy transfer [ 14 ], and in bioimaging [ 15 ].…”