Antifungal iridoids, triterpenes and phenol compounds from Alibertia myrciifolia Sprunge Ex. Schum

Luciano, João Henrique Silva; Lima, Mary Anne Sousa; Silveira, Edilberto R.; Vasconcelos, Ilka M.; Fernandes, Geórgia Sampaio; Souza, Elnatan Bezerra de

doi:10.1590/s0100-40422010000200012

Cited by 12 publications

(7 citation statements)

References 3 publications

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“…Iridoids have been reported to possess a number of biological and pharmacological activities such as neuroprotective, anti-inflammatory, immunomodulator, hepatoprotective, cardioprotective, anticancer, antioxidant, antimicrobic, hypoglycaemia, hypolipidemic, choleretic, antispasmodic, and purgative properties (Tundis et al, 2008). In particular, geniposidic acid has been reported to inhibit the mycelium development of the plant pathogenic fungus Colletotrichum gloeosporioides (Luciano, Lima & Silveira, 2010), but the present study did not find evidence of antibacterial activity at concentrations of 0.5–1,024 µg/mL. However, only moderate antibacterial activity has been reported for the related secoiridoid sweroside, with its MIC at the high concentration of 1.0 g/mL (Horn et al, 2001).…”

Section: Discussioncontrasting

confidence: 86%

Chemovariation and antibacterial activity of extracts and isolated compounds from species of Ixora and Greenea (Ixoroideae, Rubiaceae)

Buathong

Chamchumroon²,

Schinnerl

et al. 2019

PeerJ

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Background A large number of secondary metabolites can be obtained from plants used for traditional medicine in two related genera (Ixora and Greenea) in the subfamily Ixoroideae (Rubiaceae), but there are only a few detailed studies on their bioactivities. Therefore, the main goals of this study were to determine the antibacterial activities of lipophilic extracts from plants of some Ixora and Greenea species native to Thailand, and to isolate some pure compounds from those extracts. Moreover, we compared the occurrence of compounds in different plant parts of samples from different habitats to better understand their variation. Methods A total of 56 lipophilic extracts were obtained from the leaves, stem bark, and root bark of eight Ixora and two Greenea species collected at various locations in Thailand. Isolated compounds were identified using nuclear magnetic resonance. Antimicrobial activities were evaluated against four Gram-positive and nine Gram-negative human pathogenic bacterial strains. Results Extracts from I. javanica, I. nigricans, I. brunonis, and G. montana, along with isolated scopoletin, exhibited antibacterial activities against Gram-positive methicillin-resistant Staphylococcus aureus ATCC 43300, with minimum inhibitory concentration values ranging from 64 to 256 µg/mL. The occurrence of scopoletin, isofraxidin, and geniposidic acid in lipophilic extracts showed some variation among different plant parts and species. Conclusions Lipophilic extracts of Ixora and Greenea species have the potential to be developed as anti-Gram-positive agents, in particular to counter infections of methicillin-resistant S. aureus strains. The chemical profiles showed differences between floristic regions but similarity within the same plant parts.

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Section: Discussioncontrasting

confidence: 86%

Chemovariation and antibacterial activity of extracts and isolated compounds from species of Ixora and Greenea (Ixoroideae, Rubiaceae)

Buathong

Chamchumroon²,

Schinnerl

et al. 2019

PeerJ

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“…Uncaria gambir Proanthocyanidins: gambiriins A1-A2 ; gambiriins B1-B2; (+)-catechin; (+)-epicatechin; procyanidin B1; procyanidin B3; gambiriin [146] Uncaria glabrata Monoterpene indole alkaloids: 14α-hydroxyrauniticine; rauniticine; uncarine C-E; glabratine; deoxycordifoline [147] Indole alkaloid: ajmalicine Oxindole alkaloids: formosanine or uncarine B; isomitraphylline; mitraphylline [148] Triterpenes: Triterpenes: oleanolic acid; 3β,6β,19α-trihydroxyurs-12-en-28-oic acid [170] Triterpenes: 3β,6β,19α-trihydroxyurs-12-en-23-al-28-oic acid; 3β,19α-dihydroxy-6-oxo-urs-12-en-23-al-28-oic acid; 3β,19α-dihydroxy-6-oxo-urs-12-en-23-ol-28-oic acid [171] Triterpene: 23-nor-24-esomethylene-3β,6β-19α-trihydroxyurs-12-en-28 oic acid; 3β,6β,19α-trihydroxyurs-12-en-28-oic acid; 3-oxo-6β,19α-dihydroxyurs-12-en-28 oic acid; oleanic acid [192] Triterpenes: pomolic acid methyl ester; ursolic acid methyl ester; oleanolic acid methyl ester [193] Alibertia sessilis…”

Section: Nauclea Latifoliamentioning

confidence: 99%

Secondary Metabolites from Rubiaceae Species

2015

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This study describes some characteristics of the Rubiaceae family pertaining to the occurrence and distribution of secondary metabolites in the main genera of this family. It reports the review of phytochemical studies addressing all species of Rubiaceae, published between 1990 and 2014. Iridoids, anthraquinones, triterpenes, indole alkaloids as well as other varying alkaloid subclasses, have shown to be the most common. These compounds have been mostly isolated from the genera Uncaria, Psychotria, Hedyotis, Ophiorrhiza and Morinda. The occurrence and distribution of iridoids, alkaloids and anthraquinones point out their chemotaxonomic correlation among tribes and subfamilies. From an evolutionary point of view, Rubioideae is the most ancient subfamily, followed by Ixoroideae and finally Cinchonoideae. The chemical biosynthetic pathway, which is not so specific in Rubioideae, can explain this and large amounts of both iridoids and indole alkaloids are produced. In Ixoroideae, the most active biosysthetic pathway is the one that produces iridoids; while in Cinchonoideae, it produces indole alkaloids together with other alkaloids. The chemical biosynthetic pathway now supports this botanical conclusion.

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“…25) Triohima B (127) isolated from Triosteum himalayanum showed significant inhibitory activity toward plant pathogenic fungus Peronophythora litchi with EC 50 value of 34.0 mg/ml. 58) A decoction of the roots and flowers of the Iranian flora Eremostachys laciniata (Lamiaceae) has traditionally been taken orally for treatment of allergies, headache and liver disease.…”

Section: Biological and Pharmacological Activity Of Naturally Occurrimentioning

confidence: 99%

Naturally Occurring Iridoids and Secoiridoids. An Updated Review, Part 4

Dinda

Debnath

Banik

2011

CHEMICAL & PHARMACEUTICAL BULLETIN

131

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Antifungal iridoids, triterpenes and phenol compounds from Alibertia myrciifolia Sprunge Ex. Schum

Cited by 12 publications

References 3 publications

Chemovariation and antibacterial activity of extracts and isolated compounds from species of Ixora and Greenea (Ixoroideae, Rubiaceae)

Chemovariation and antibacterial activity of extracts and isolated compounds from species of Ixora and Greenea (Ixoroideae, Rubiaceae)

Secondary Metabolites from Rubiaceae Species

Naturally Occurring Iridoids and Secoiridoids. An Updated Review, Part 4

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