Constituintes químicos e atividade antioxidante de extratos das folhas de Terminalia fagifolia Mart. et Zucc

Ayres, Mariane Cruz Costa; Chaves, Mariana Helena; Rinaldo, Daniel; Vilegas, Wagner; Júnior, Gerardo Magela Vieira

doi:10.1590/s0100-40422009000600028

Cited by 22 publications

(21 citation statements)

References 17 publications

(22 reference statements)

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“…The infrared (IR) ( Figure S11), 1 H and 13 C nuclear magnetic resonance (NMR) spectra (Table S1, Figures S12-S15) allied to optical rotations ([a] 27 D -43.5 (c 0.02, MeOH) and [a] 27 D -16.3 (c 0.02, Me 2 CO)) were similar to those published in the literature, [30][31][32] indicating a 2S,3R absolute configuration, and are consistent with the structure of (-)-catechin ( Figure 2).…”

Section: Resultssupporting

confidence: 73%

Antifungal and cytotoxicity activities of Banisteriopsis argyrophylla leaves

Oliveira

Silva

Martins

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives This work aimed to evaluate the antifungal and cytotoxic activity of the EtOH extract and fractions of Banisteriopsis argyrophylla leaves, and to perform the identification of these bioactive metabolites. Methods The EtOAc fraction (EAF) obtained from the ethanolic extract of B. argyrophylla leaves showed better antifungal potential against Candida spp. In this fraction, ten flavonoids have been identified by UHPLC‐ESI‐MSn. Then, EAF was submitted to column chromatography to give four new fractions (A1–A4). The cytotoxicity was determined against Vero cells. Key findings The EAF showed better antifungal potential against Candida spp. with minimum inhibitory concentrations (MICs) between 31.25 and 93.75 μg/ml. The (–)‐catechin (fraction A1) showed a MIC of 2.83 μg/ml against Candida glabrata. Fractions A2, A3 and A4 were rich in quercetins and kaempferols and showed good inhibitory concentrations (5.86–46.87 μg/ml) against C. albicans, C. glabrata and C. tropicalis. Conclusions The EtOH extract, fractions and the isolated (–)‐catechin showed lower toxicity to Vero cells than cisplatin, used as a positive control. Thus, the leaves of B. argyrophylla are a promising source of antifungal agents.

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Section: Resultssupporting

confidence: 73%

Antifungal and cytotoxicity activities of Banisteriopsis argyrophylla leaves

Oliveira

Silva

Martins

et al. 2018

Journal of Pharmacy and Pharmacology

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“…Para obtenção dos dados espectroscópicos e espectrométricos foram utilizados: espectrômetro de ressonância magnética nuclear de 11,7 T (Varian Ò Inova), operando a 500 MHz para 1 H e 125 MHz para 13 C, TMS foi usado como padrão interno para determinação dos deslocamentos químicos; espectrofotômetro de infravermelho Vol. 34,No. 7 Jasco ® , modelo FT/IR -4100; espectrofotômetro de ultravioleta/ visível (Hach ® ), modelo DR/4000 U; espectrômetro de massas de alta resolução (EM-IES-QTOF) (FCF-USP-RP) ultrOTOFQ-ESI-TOF Bruker Daltonics ® (Billerica, MA -USA) acoplado ao cromatógrafo líquido de alta eficiência Shimadzu ® equipado com detector de arranjo de foto diodos e coluna de fase reversa C 18 Shimadzu ® (250 x 4,6 mm d.i.)…”

Section: Determinação Estruturalunclassified

“…Esse fato pode ser explicado pela presença de duas hidroxilas fenólicas em 8 e três em 5 e 6. 26,34 A rutina (3) apresentou CE 50 = 21,6 ± 0,6, enquanto que o kaempferol-3-O-β-D-glucopiranosídeo (4) exibiu CE 50 = 457,8 ± 1,0. A menor atividade antirradicalar de 4 em comparação à rutina (3) é justificada devido à existência do sistema orto-di-hidroxi no anel B de 3.…”

Section: Composição Químicaunclassified

“…A menor atividade antirradicalar de 4 em comparação à rutina (3) é justificada devido à existência do sistema orto-di-hidroxi no anel B de 3. 34 O kaempferol (7) (CE 50 = 27,9 ± 0,6) não possui o sistema orto-dihidroxi no anel B sendo, portanto, sua atividade antirradicalar menos pronunciada que em 3. A menor atividade antirradicalar da substância 4, um derivado do kaempferol, (CE 50 = 457,8 ± 1,0), em comparação com 7, é justificada pela presença da glicose na posição 3 de 4.…”

Section: Composição Químicaunclassified

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Identificação de alguns constituintes químicos de Indigofera hirsuta Linn. (Fabaceae) por CLAE-IES-EM (TOF) e avaliação da atividade antirradicalar

Moura¹,

Vilega²,

Santos³

2011

Quím. Nova

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Recebido em 14/7/10; aceito em 21/2/11; publicado na web em 15/4/11 IDENTIFICATION OF SOME CHEMICAL CONSTITUENTS OF Indigofera hirsuta Linn. (FABACEAE) BY HPLC-ESI-MS (TOF) AND EVALUATION OF THE ANTIRADICAL ACTIVITY. A rapid analytical approach, suitable to characterize the compounds present in the aqueous and methanol extracts prepared from the aerial parts of Indigofera hirsute, was developed. The method based on high-performance liquid chromatography coupled to mass spectrometry, electrospray positive ionization and detection by time of flight (HPLC-ESI-MS-TOF) identified, tryptophan, uracil, rutin, kaempferol-3-O-β-D-glucopyranoside, gallic acid and methyl gallate. The antiradical activity of this extract was evaluated using DPPH assay, with gallic acid as antiradical pattern. The study revealed the antiradical activity of methyl galatte (EC 50 = 5 ± 0.3 μg mL -1 ) galic acid (EC 50 = 5 ± 0.2 μg mL -1 ) and rutin (EC 50 = 21.6 ± 0.6 μg m L -1 ), isolated from methanol extract (EC 50 = 67.7 ± 0.9 μg mL -1 ), which showed strong antiradical activity.

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“…The compounds were identified by comparison of their NMR data with those reported in the literature (Alam et al, 1996;Ayres et al, 2009;Daniewski et al, 1996;Nyasse et al, 1988 143.5, 122.9, 121.6, 118.4, 117.4, 74.8, 39.8, 39.4, 37.5, 32.8, 31.5, 28.0, 24.8, 24.4, 23.9, 22.7, 21.5, 20.6, 19.7, 12.5, 11.8, 11.3 122.0, 100.9, 78.9, 77.9, 77.1, 75.6, 69.8, 61.5, 56.5, 55.8, 50.0, 45.6, 42.1, 39.5, 38.4, 37.0, 36.5, 35.9, 33.7, 31.6, 31.4, 29.3, 28.9, 28.0, 25.8, 24.0, 22.9, 20.9, 19.5, 19.0, 18.7, 18.5, 11.6, 11.4. mustakone 203.4, 120.8, 171.4, 55.8, 54.7, 45.6, 22.8, 35.9, 57.8, 32.4, 19.6, 20.6, 20.5, 24.3 Different letters in the same column differ at 5% probability by Tukey test. SE = standard error.…”

Section: Isolation Of the Constituents Of Active Extractmentioning

confidence: 99%

Effect of extracts of Trichilia silvatica C. DC., on development and reproduction parameters of Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae)

Freitas¹,

Formagio²,

Pereira³

et al. 2014

Afr. J. Biotechnol.

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The objective of this study was to evaluate the effects of the methanolic extracts from the leaves, bark and flowers of Trichilia silvatica on Spodoptera frugiperda. Also, it was use in evaluating the total phenolic and flavonoid content of methanolic extracts. We also reported chemical study on the most active extract. Corn leaves were immersed in a 1% methanolic extract solution and fed to second instars of S. frugiperda. The extract of the T. silvatica (LTS) leaves decreased the viability of the larva, prolonged larval duration, affected the pupal biomass, decreased the period of oviposition and the number of eggs as well as affected the egg viability. The methanolic extract of the T. silvatica (BTS) bark decreased the larval viability, oviposition period, number of eggs and egg viability. The flower extract of T. silvatica (FTS) decreased the larval viability and period of oviposition. In relation to the constituent contents, the methanolic extract of the leaves showed highest total phenol (233.37 mg gallic acid/g of extract) and flavonoid (53.17 mg quercetin/g of extract) content. The chemical study of the FTS resulted in α-tocopherol, sitosterol 3-O-glucopyranoside, mustakone and N-metilproline. Our results indicate that the extracts affected the biology of S. frugiperda, with LTS being the most promising.

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Constituintes químicos e atividade antioxidante de extratos das folhas de Terminalia fagifolia Mart. et Zucc

Cited by 22 publications

References 17 publications

Antifungal and cytotoxicity activities of Banisteriopsis argyrophylla leaves

Antifungal and cytotoxicity activities of Banisteriopsis argyrophylla leaves

Identificação de alguns constituintes químicos de Indigofera hirsuta Linn. (Fabaceae) por CLAE-IES-EM (TOF) e avaliação da atividade antirradicalar

Effect of extracts of Trichilia silvatica C. DC., on development and reproduction parameters of Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae)

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