Derivados oleananos e ursanos e sua importância na descoberta de novos fármacos com atividade antitumoral, anti-inflamatória e antioxidante

Vechia, Luciana Dalla; Gnoatto, Simone Cristina Baggio; Gosmann, Grace

doi:10.1590/s0100-40422009000500031

Cited by 17 publications

(4 citation statements)

References 29 publications

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“…The triterpene acids exhibit unique and important biological and pharmacological activities, including anti-inflammatory, antimicrobial, antiviral, cytotoxic and cardiovascular effects [1,2,3,4,5]. Synthesis of triterpene derivatives is a strategy to obtain compounds with enhanced bioactivity by, for example, the introduction of electron-withdrawing/donating groups [6].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives

et al. 2012

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Betulinic, ursolic and oleanolic acids isolated from the aerial parts of Eriope blanchetii (Lamiaceae) were subjected to different esterification reactions, yielding 12 C-3 position ester derivatives. All compounds were identified using spectroscopic techniques, such as IR, 1H-NMR and MS. The derivatives were further investigated for their antioxidant level, Artemia salina lethality and antimicrobial activity.

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Section: Introductionmentioning

confidence: 99%

Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives

et al. 2012

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“…However, the same fractions and triterpenes exhibited antibacterial action against Staphylococcus aureus . Triterpenes also exhibit a large spectrum of antitumor properties which are likely related to their anti-inflammatory activity [7]. …”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects in muscle injury by transdermal application of gel with Lychnophora pinaster aerial parts using phonophoresis in rats

Abreu¹,

Corrêa²,

Silva³

et al. 2013

BMC Complement Altern Med

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BackgroundLycnophora pinaster is used by the traditional Brazilian medicine for the treatment of inflammations. Anti-inflammatory activity of Lycnophora pinaster was investigated for extracts, fractions, and isolated compounds of their aerial parts. The hexane extract (HE) provided α-amyrin, lupeol, mixture of α-amyrin and lupeol, mixture of 3-O-acetyl-lupeol and 3-O-acetyl-pseudotaraxasterol, and mixture of the steroids stigmasterol and sitosterol. The aqueous extract (WE) provided a fraction containing alkaloids (AF) and another one containing phenolic compounds (PF).MethodsThe crude hexane extract obtained from aerial parts of L. pinaster was submitted to chromatographic fractionation. The fractionation of PF was performed by preparative HPLC analysis, providing the flavonoid quercetin. The extracts, fractions, and compounds isolated from L. pinaster were tested to evaluate the anti-inflammatory activity by experimental model of impact injury, followed by transdermal application of gels with these samples. The application of the gels was performed using phonophoresis in rat paws after induction of muscle injury. Histological analysis was based on scores assigned by the capacity of decreasing the lesion.ResultsHE and WE exhibited anti-inflammatory activity. Some fractions, triterpenes, and steroids also reduced the inflammatory infiltrates caused by muscle injury. Lupeol promoted a significant reduction of inflammation. Quercetin also provided significant results, promoting the greatest decreases in muscle injury.ConclusionThe results of this work suggest that topical application of triterpenes, steroids and flavonoid significantly decreases the inflammatory process generated by muscle injury. The transdermal application using phonophoresis in rat paws of gel with lupeol and quercetin attenuates the inflammation.

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“…A inflamação crônica é associada com uma alta incidência de câncer. O processo inflamatório é geralmente acompanhado de estresse oxidativo, responsável por gerar mutações progressivas levando ao desenvolvimento tumoral (VECHIA et al, 2009).…”

Section: Atividade Antiinflamatóriaunclassified

“…A atividade antioxidante, assim como a atividade antiinflamatória, também está relacionada às atividades antitumoral e quimiopreventiva, pois, como apresentado anteriormente, o estresse oxidativo, ou seja, a produção de radicais livres pode causar dano ao DNA provocando, assim, mutações que podem ser permanentes e, muitas vezes, levar à malignidade (VECHIA et al, 2009).…”

Section: Atividade Antiinflamatóriaunclassified

Avaliação biológica de frutas do Cerrado brasileiro

Malta¹

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v vi AGRADECIMENTOSMais difícil que realizar este trabalho, é encontrar uma forma de agradecer por toda ajuda que recebi das pessoas especiais com quem convivo e que tanto me ajudaram nesta etapa de minha vida.Primeiramente agradeço a Deus, pela ajuda e luz que me guiaram por toda minha vida, dando-me força para acreditar em meu potencial e nunca desistir diante dos problemas.Aos meus pais, sem palavras para descrever o apoio, a confiança e o empenho de sempre para a construção da minha carreira profissional. Ofereço a vocês este título de doutora.À minha família, obrigada pelo apoio e encorajamento.Aos membros da banca, pelas sugestões valiosas.À professora Gláucia Pastore, minha orientadora, que sempre acreditou em meu potencial, e ofereceu-me ótimas oportunidades durante todos estes anos.A todos os amigos do laboratório de Bioaromas (CD, Fábio, Juliano Bicas,

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Derivados oleananos e ursanos e sua importância na descoberta de novos fármacos com atividade antitumoral, anti-inflamatória e antioxidante

Cited by 17 publications

References 29 publications

Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives

Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives

Anti-inflammatory effects in muscle injury by transdermal application of gel with Lychnophora pinaster aerial parts using phonophoresis in rats

Avaliação biológica de frutas do Cerrado brasileiro

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