Constituintes químicos do caule de Senna reticulata Willd. (Leguminoseae): Chemical constituents isolated from the wood of Senna reticulata Willd.

Santos, Rogério Nunes dos; Silva, Maria Goretti de Vasconcelos; Filho, Raimundo Braz

doi:10.1590/s0100-40422008000800011

Cited by 20 publications

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“…Three plant species of special relevance because of their widespread utilization in traditional medicine in Costa Rica as anti-inflammatories are Petiveria alliaceae , Phyllanthus niruri and Senna reticulata [1]. Senna reticulata is a shrub belonging to the Fabaceae family, originally from Mesoamerica and South America (to Brazil), whose leaves and stems are used traditionally for rheumatism and skin conditions [2]. Phyllanthus niruri is a shrub native to America and tropical areas of India and China, which belongs to the Phyllanthaceae family, and has diuretic and hepatoprotective properties [3].…”

Section: Introductionmentioning

confidence: 99%

“…Studies have attributed anti-inflammatory and other bioactivities mainly to anthraquinones present in S. reticulate [2], sulfur containing compounds in P. alliaceae [4], and lignans such as phyllanthosides in the case of P. niruri . More recent studies have shown the synergic effect of different families of phenolic compounds in bioactivity studies, for instance showing the important effects of proanthocyanidins on antioxidant and cytotoxic bioactivities [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…More recent studies have shown the synergic effect of different families of phenolic compounds in bioactivity studies, for instance showing the important effects of proanthocyanidins on antioxidant and cytotoxic bioactivities [5,6]. Regarding phenolic compounds, mainly flavonoids such as kaempferol derivatives have been reported in S. reticulata [2] [7]; quercetin derivatives in P. alliacea [8] and P. niruri [9]; whereas caffeic acid derivatives and ellagitannins have also been reported in P. niruri [10]. Flavan-3-ols, including catechin and epicatechin monomers have been reported in P. niruri [11], whereas no detailed studies on proanthocyanidin oligomers have been performed in any of these three species.…”

Section: Introductionmentioning

confidence: 99%

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Proanthocyanidin Characterization, Antioxidant and Cytotoxic Activities of Three Plants Commonly Used in Traditional Medicine in Costa Rica: Petiveria alliaceae L., Phyllanthus niruri L. and Senna reticulata Willd.

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The phenolic composition of aerial parts from Petiveria alliaceae L., Phyllanthus niruri L. and Senna reticulata Willd., species commonly used in Costa Rica as traditional medicines, was studied using UPLC-ESI-TQ-MS on enriched-phenolic extracts. Comparatively, higher values of total phenolic content (TPC), as measured by the Folin-Ciocalteau method, were observed for P. niruri extracts (328.8 gallic acid equivalents/g) than for S. reticulata (79.30 gallic acid equivalents/g) whereas P. alliaceae extract showed the lowest value (13.45 gallic acid equivalents/g). A total of 20 phenolic acids and proanthocyanidins were identified in the extracts, including hydroxybenzoic acids (benzoic, 4-hydroxybenzoic, gallic, prochatechuic, salicylic, syringic and vanillic acids); hydroxycinnamic acids (caffeic, ferulic, and p-coumaric acids); and flavan-3-ols monomers [(+)-catechin and (−)-epicatechin)]. Regarding proanthocyanidin oligomers, five procyanidin dimers (B1, B2, B3, B4, and B5) and one trimer (T2) are reported for the first time in P. niruri, as well as two propelargonidin dimers in S. reticulata. Additionally, P. niruri showed the highest antioxidant DPPH and ORAC values (IC50 of 6.4 μg/mL and 6.5 mmol TE/g respectively), followed by S. reticulata (IC50 of 72.9 μg/mL and 2.68 mmol TE/g respectively) and P. alliaceae extract (IC50 >1000 μg/mL and 1.32 mmol TE/g respectively). Finally, cytotoxicity and selectivity on gastric AGS and colon SW20 adenocarcinoma cell lines were evaluated and the best values were also found for P. niruri (SI = 2.8), followed by S. reticulata (SI = 2.5). Therefore, these results suggest that extracts containing higher proanthocyanidin content also show higher bioactivities. Significant positive correlation was found between TPC and ORAC (R2 = 0.996) as well as between phenolic content as measured by UPLC-DAD and ORAC (R2 = 0.990). These findings show evidence for the first time of the diversity of phenolic acids in P. alliaceae and S. reticulata, and the presence of proanthocyanidins as minor components in latter species. Of particular relevance is the occurrence of proanthocyanidin oligomers in phenolic extracts from P. niruri and their potential bioactivity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Proanthocyanidin Characterization, Antioxidant and Cytotoxic Activities of Three Plants Commonly Used in Traditional Medicine in Costa Rica: Petiveria alliaceae L., Phyllanthus niruri L. and Senna reticulata Willd.

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Arnáez

et al. 2017

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“…H. S. Irwin & Barneby, também conhecida como mata-pasto, é uma planta pioneira considerada uma das mais eficientes colonizadoras em áreas abertas nas planícies aluviais da Amazônia, ocorrendo principalmente próxima a rios e em pastos abandonados (PAROLIN, 2005). Possui um valor medicinal importante para a região, no tratamento de obstruções do fígado e no combate ao reumatismo, além de apresentar diferentes antraquinonas, substâncias de interesse para a indústria alimentícia, de corantes e de cosméticos (SANTOS et al, 2008). Devido à preocupação com a geração de energias alternativas para mitigação dos efeitos das mudanças climáticas globais, S. reticulata 508 FLORESTA,Curitiba,PR,v.…”

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DIVERSIDADE E ESTRUTURA GENÉTICA DE Senna reticulata

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Bentes³

et al. 2015

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ResumoSenna reticulata (Willd.) H. S. Irwin & Barneby é uma planta arbórea pioneira em áreas abertas de planícies aluviais da Amazônia e frequentemente usada como planta medicinal. Devido à escassez de informações sobre a diversidade da espécie, caracterizou-se a diversidade genética de populações naturais de S. reticulata por meio de marcadores AFLP. Foram coletadas amostras em quatro populações ao longo do trecho do gasoduto Coari-Manaus: Santa Luzia do Baixio, Nossa Senhora de Nazaré, Matrinchã e Esperança II. Foram utilizados quatro primers de AFLP, resultando num total de 330 locos polimórficos variando de 76,97% a 92,42% entre as populações. O dendrograma e a análise bayesiana de agrupamento permitiram a visualização de um grupo formado pelas populações de Nossa Senhora de Nazaré e Esperança II e outro agrupamento formado por Santa Luzia do Baixio. A população de Matrinchã foi caracterizada como a composição de genes dos dois grupos. O fluxo gênico médio estimado entre as populações foi de 4,04 e o teste de Mantel indicou baixa correlação (r = 0,268) entre as matrizes de distância geográfica e distância genética. De acordo com a análise molecular de variância, a maior diferenciação genética está dentro das populações (82,29%), enquanto a variação interpopulacional foi de 17,71%. Palavras-chave: Diferenciação populacional; marcador AFLP; variabilidade genética. AbstractGenetic diversity and structure of Senna reticulata. S. reticulata (Willd.) H. S. Irwin & Barneby is a pioneer tree that grows in open areas of the Amazon floodplains and is often used as a medicinal plant species. Due to the lack of information on diversity for this species, this research aimed to characterize the genetic diversity of natural populations of S. reticulata by AFLP markers. The samples were collected in four populations along the natural gas pipeline pathway of Coari-Manaus: Santa Luzia do Baixio, Nossa Senhora de Nazaré, Matrinchã and Esperança II. Four AFLP primers were used, resulting in a total of 330 polymorphic loci ranged from 76.97% to 92.42% among populations. The clustering and Bayesian cluster analysis allowed to discriminate a group composed by the Nossa Senhora de Nazaré and Esperança II populations and another group composed by Santa Luzia do Baixio. Matrinchã population was characterized as a gene composition from both groups. Average gene flow among populations was 4.04 and Mantel test showed low correlation (r = 0.268) between the pairwise of geographic and genetic distance matrices. According to molecular variance analysis, the most genetic differentiation is within populations (82.29%), while the inter population variation was around 17.71%.

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“…The genus Cassia is known for the presence of a variety of compounds. Anthraquinones are the main class of compounds isolated from it [17,22–25]. However, previous investigations led to the isolation of flavonoids [26–29], piperidine alkaloids [30], stilbenoids [30] and aliphatic esters [16].…”

Section: Introductionmentioning

confidence: 99%

Anti-Mayaro virus activity of Cassia australis extracts (Fabaceae, Leguminosae)

et al. 2014

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BackgroundThe arthropod-borne Mayaro virus (MAYV) causes ‘Mayaro fever’, a disease of medical significance, primarily affecting individuals in permanent contact with forested areas in tropical South America. Studies showed that the virus could also be transmitted by the mosquito Aedes aegypti. Recently, MAYV has attracted attention due to its likely urbanization. To date, there are no drugs that can treat this illness.MethodsFractions and compounds were obtained by chromatography from leaf extracts of C. australis and chemically identified as flavonoids and condensed tannins using spectroscopic and spectrometric techniques (UV, NMR, and ESI-FT-ICR MS). Cytotoxicity of EtOAc, n-BuOH and EtOAc-Pp fractions were measured by the dye-uptake assay while their antiviral activity was evaluated by a virus yield inhibition assay. Larvicidal activity was measured by the procedures recommended by the WHO expert committee for determining acute toxicity.ResultsThe following group of substances was identified from EtOAc, n-BuOH and EtOAc-Pp fractions: flavones, flavonols, and their glycosides and condensed tannins. EtOAc and n-BuOH fractions inhibited MAYV production, respectively, by more than 70% and 85% at 25 μg/mL. EtOAc-Pp fraction inhibited MAYV production by more than 90% at 10 μg/mL, displaying a stronger antiviral effect than the licensed antiviral ribavirin. This fraction had an excellent antiviral effect (IC90 = 4.7 ± 0.3 μg/mL), while EtOAc and n-BuOH fractions were less active (IC90 = 89.1 ± 4.4 μg/mL and IC90 = 40.9 ± 5.7 μg/mL, respectively).ConclusionsC. australis can be used as a source of compounds with anti-Mayaro virus activity. This is the first report on the biological activity of C. australis.

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Constituintes químicos do caule de Senna reticulata Willd. (Leguminoseae): Chemical constituents isolated from the wood of Senna reticulata Willd.

Cited by 20 publications

References 4 publications

Proanthocyanidin Characterization, Antioxidant and Cytotoxic Activities of Three Plants Commonly Used in Traditional Medicine in Costa Rica: Petiveria alliaceae L., Phyllanthus niruri L. and Senna reticulata Willd.

Proanthocyanidin Characterization, Antioxidant and Cytotoxic Activities of Three Plants Commonly Used in Traditional Medicine in Costa Rica: Petiveria alliaceae L., Phyllanthus niruri L. and Senna reticulata Willd.

DIVERSIDADE E ESTRUTURA GENÉTICA DE Senna reticulata

Anti-Mayaro virus activity of Cassia australis extracts (Fabaceae, Leguminosae)

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