Diterpenos tipo abietano isolados de Plectranthus barbatus Andrews

Albuquerque, Roberto Lima de; Kentopff, Marta R.; Machado, Maria Iracema L.; Silva, Maria Goretti V.; Matos, Francisco José de Abreu; Morais, Selene Maia de; Braz‐Filho, Raimundo

doi:10.1590/s0100-40422007000800016

Cited by 20 publications

(13 citation statements)

References 6 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2 In general, are rich source of essential oils, terpenoids and phenol compounds. 3 Pharmacological properties such as anti-inflammatory, 4 antioxidant, 5 antimicrobial, 6 anti-tumoral 7 and diuretic 8 have been demonstrated for several isolated compounds from Plectranthus, corroborating with its larger medicinal uses.…”

Section: Introductionmentioning

confidence: 66%

Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

Ávila¹,

Pinto²,

Sousa³

et al. 2016

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Five new diterpenes derivatives named as ornatin A, B, C, D and E, in addition to six known related diterpenes were isolated from the aerial parts of cultivated specimens of Plectranthus ornatus. The structures were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS) and comparison with published NMR data of analogous compounds. All isolated compounds were assayed against four human cancer cell lines, and Gram-positive and Gram-negative bacteria strains. None of them showed any cytotoxic activity, but ornatin C, D, E and three related diterpenes displayed marginal bactericidal or bacteriostatic effects against the Gram-positive strains. Keywords: Plectranthus ornatus, diterpenes, ent-clerodanes, bacteriostatic IntroductionThe genus Plectranthus L'Her (Lamiaceae, subfamily Nepetoideae, tribe Ocimeae, subtribe Plectranthinae) comprises approximately 300 species largely distributed over the African, Asian and Australian continents. 1 Plectranthus is a large genus well known by its diversity of ethnobotanical uses, being especially indicated to treat digestive disorders, skin diseases, infections and respiratory problems. 2 In general, are rich source of essential oils, terpenoids and phenol compounds. 3 Pharmacological properties such as anti-inflammatory, 4 antioxidant, 5 antimicrobial, 6 anti-tumoral 7 and diuretic 8 have been demonstrated for several isolated compounds from Plectranthus, corroborating with its larger medicinal uses.Plectranthus ornatus Codd (syn. Coleus comosus Hochst. ex Gurke) is a perennial and aromatic herb, widespread around the new world. 9 In the northeast of Brazil, P. ornatus, popularly known as "malva santa" or "boldo miúdo", is cultivated as a very important medicinal plant, indicated as analgesic and particularly to treat gastric disorders. 10 Several antimicrobial labdanes, ent-clerodanes, and halimane-type diterpenoids have been previously isolated from P. ornatus. 11 As part of a multidisciplinary program, where the efforts are devoted to study medicinal plants or congeners, in order to unveil their pharmacological or biological properties, herein we describe the isolation and characterization of five new diterpenes derivatives together with six known compounds from the aerial parts of cultivated specimens of P. ornatus, as well as the results of pharmacological and biological assays with the isolated secondary metabolites (Figure 1). Ávila et al. 1015 Vol. 28, No. 6, 2017 Experimental General experimental proceduresOptical rotations were measured on a PerkinElmer 341 digital polarimeter. Infrared (IR) spectra were obtained on a PerkinElmer FT-IR spectrum 1000 spectrometer. Accurate mass spectra were acquired on a liquid chromatography-mass spectrometry ion-trap and time-of-flight (LCMS-IT-TOF, Shimadzu) spectrometer. Nuclear magnetic resonance (NMR) spectra were performed either on Bruker DPX-300 or DRX-500 spectrometers. Open column chromatography (CC) were carried out wit...

show abstract

Section: Introductionmentioning

confidence: 66%

Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

Ávila¹,

Pinto²,

Sousa³

et al. 2016

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…(Lamiaceae) submetidas a diferentes processos de secagem de diversos diterpenos (Albuquerque et al, 2007;Bhat et al, 1977;Kelecom, 1984;Kelecom et al, 1987;Tandon et al, 1977;Wang et al, 1973;Zelnik et al, 1977), além de derivados fenólicos, tais como nepetoidinas A e B (Grayer et al, 2003) e o ácido rosmarínico (Falé et al, 2009). Estudos mais recentes têm reportado seu uso como um ingrediente de alimentos funcionais e suplementos alimentares para perda e controle de peso, tendo a forskolina como principal componente (Henderson et al, 2005;Kamohara & Noparatanawong, 2013;Kamohara et al, 2015).…”

unclassified

Parâmetros de qualidade físico-químicos e avaliação da atividade antioxidante de folhas de Plectranthus barbatus Andr. (Lamiaceae) submetidas a diferentes processos de secagem

Silva

Mendes

Almeida

et al. 2016

Rev. bras. plantas med.

View full text Add to dashboard Cite

Quality of the leaves of Plectranthus barbatus Andr. (Lamiaceae) dried in solar dryer and oven. This paper describes the physicochemical composition, the evaluation of the antioxidant activity by free DPPH radicals using the scavenging method, the determination of flavonoids and total phenolic compounds of ethanol, acetone and aqueous extracts of the medicinal plant Plectranthus barbatus Andr. (Lamiaceae), dehydrated in solar dryer and circulation oven at 60 °C. Water activity rates for two drying methods were below the minimum necessary for growth and toxin production of important food pathogens. Physicochemical results showed that both processes were effective in the dehydration of P. barbatus. The results demonstrated that the acetone (over) and ethanol (over and solar dryer) extracts showed the highest content of total phenols. The ethanol extract (over) showed the highest amount of flavonoids and better antioxidant activity (75.71 ± 10.57 µg L -1 ).

show abstract

“…pela morfologia semelhante (Costa, 2006). Ainda não está referenciado o composto da malva-santa responsável pelo efeito alelopático, mas, provavelmente, será um dos diterpenos barbatusina, ciclobutatusina, plectrina ou cariocal (Albuquerque et al, 2007). Salienta-se que, estudos que visem o conhecimento da ecofisiologia da germinação das espécies de plantas daninhas podem contribuir para auxiliar na elaboração de novos métodos de controle, designadamente o uso de herbicidas naturais ou mesmo seleção de plantas com alto potencial alelopático o que possibilitaria a diminuição do uso de herbicidas sintéticos.…”

Section: Introductionunclassified

Efeitos alelopáticos de extratos aquosos de folhas de Amburana cearensis e Plectranthus barbatus na germinação de Amaranthus deflexus

Lessa¹,

Silva²,

Barreto³

et al. 2017

Rev. Ciênc. Agr.

View full text Add to dashboard Cite

R E S U M OO objetivo do trabalho foi verificar possíveis efeitos alelopáticos exercidos por extratos aquosos de folhas de cumaru (Amburana cearensis) e malva-santa (Plectranthus barbatus) sobre a germinação de sementes de caruru (Amaranthus deflexus). As sementes de caruru foram colocadas para germinar em placas de petri em contato com extratos vegetais aquosos obtidos a partir de folhas de cumaru e malva-santa sob dois métodos de preparação -extrato aquoso das folhas frescas e extrato aquoso por infusão das folhas secas -e duas dosagens -50 e 100 g L -1 . Foi utilizado o delineamento inteiramente casualizado com 4 repetições e uma testemunha isolada compondo um fatorial 2 x 2 x 2 + 1. Foi determinada a porcentagem final e o índice de velocidade de germinação. A análise dos dados revelou diferença entre os tratamentos e a testemunha, condicionando graus diferentes de alelopatia para os extratos usados afetando drasticamente a germinação do caruru. O extrato a base de folhas frescas de cumaru apresenta alto nível de alelopatia de modo a impedir quase que completamente a germinação do caruru. A dose, com efeito, mais prejudicial para a germinação do caruru foi a de 100 g L -1 . Palavras-chave: Alelopatia; caruru; folhas frescas; infusão A B S T R A C TThe objective was to verify possible allelopathic effects exerted by aqueous extracts of leaves of Amburana cearensis and Plectranthus barbatus on the seed germination of the weed Amaranthus deflexus. A. deflexus seeds were put to germinate in Petri plates containing aqueous plant extracts obtained from A. cearensis and P. barbatus leaves under two tillage methods -aqueous extract from fresh leaves and aqueous extract by infusion of dried leaves -and two dosages -50 and 100 g L -1 . We used a completely randomized design with 4 replications and a detached witness composing a factorial 2 x 2 x 2 + 1. It was determined the final percentage and germination speed index. Data analysis revealed differences between treatments and the witness, conditioning different allelopathy levels for the extracts used, dramatically affecting the germination of A. deflexus. The A. cearensis fresh leaves extracts has a high level of allelopathy since they prevent almost completely the germination of the weed A. deflexus. The most damaging dosage for germination of A. deflexus was 100 g L -1 .

show abstract

Diterpenos tipo abietano isolados de Plectranthus barbatus Andrews

Cited by 20 publications

References 6 publications

Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

Parâmetros de qualidade físico-químicos e avaliação da atividade antioxidante de folhas de Plectranthus barbatus Andr. (Lamiaceae) submetidas a diferentes processos de secagem

Efeitos alelopáticos de extratos aquosos de folhas de Amburana cearensis e Plectranthus barbatus na germinação de Amaranthus deflexus

Contact Info

Product

Resources

About