Chemical study of leaves of Chrysophyllum marginatum (Hook. &amp; Arn.) Radlk (Sapotaceae)

Silva, Viviane Cândida da; Lopes, Manuela; Bolzani, Vanderlan da Silva

doi:10.1590/s0100-40422006000300016

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…& Arn. [47][48][49]. The reported antioxidant activity is suspected to be due to isolated phenolic acids (caffeic, trans-ferulic, and gallic acids) and flavonol derivatives (3 aglycones viz, kaempferol, quercetin, myricetin, and isoquercitrin).…”

Section: Phenolic Isolationmentioning

confidence: 99%

Phenolic Constituents of Chrysophyllum oliviforme L. Leaf Down-Regulate TGF-β Expression and Ameliorate CCl4-Induced Liver Fibrosis: Evidence from In Vivo and In Silico Studies

et al. 2019

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The prevalence of hepatic diseases globally and in Egypt particularly necessitates an intensive search for natural hepatoprotective candidates. Despite the traditional use of Chrysophyllum oliviforme L. and C. cainito L. leaves in the treatment of certain ailments, evidence-based reports on their bioactivities are limited. In this work, in vivo and in silico studies were conducted to evaluate their methanol extracts potential to alleviate liver damage in CCl4-intoxicated rats, in addition to their antioxidant activity and identifying the molecular mechanisms of their phenolic constituents. The extracts restored the altered total cholesterol (TC), triglycerides (TG), high-density lipoproteins (HDL), alanine aminotransferase ALT, aspartate aminotransferase AST, total protein, and albumin. Histopathological architecture, DNA fragmentation, and mRNA expression level of TGF-β1 also confirmed the anti-fibrotic activity of the two extracts. The total phenolic content (TPC) in C. oliviforme ethanol extract exceeded that in C. caimito. Additionally, the malondialdehyde (MDA), reduced glutathione (GSH), and total antioxidant capacity (TAC) levels assured the antioxidant potential. Seven phenolics; quercetin, isoquercitrin, myricetin, kaempferol, and caffeic, trans-ferulic, and gallic acids were isolated from the ethanol extract of C. oliviforme. The molecular docking of isolated compounds revealed a low binding energy (kcal/mol with TGF-β1, thus confirming the hepatoprotctive activity of the extracts. In conclusion, the C. oliviforme leaves could be considered as potent safe raw material for the production of herbal formulations to alleviate hepatic toxicity after preclinical safety study.

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Section: Phenolic Isolationmentioning

confidence: 99%

Phenolic Constituents of Chrysophyllum oliviforme L. Leaf Down-Regulate TGF-β Expression and Ameliorate CCl4-Induced Liver Fibrosis: Evidence from In Vivo and In Silico Studies

et al. 2019

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“…Chrysophyllum cainito belongs to the family sopotaceae and their chemical and biological studies are scarce [2] and there is lack of chemical information about the genus chrysophyllum, but a number of reports concerning the isolation and characterization of bioactive compounds from various parts of the plant have appeared in the literature.…”

Section: Ogunmola O~ S Bolaji and A Sodamadementioning

confidence: 99%

THE CHEMICAL AND MEDICINAL POTENTIALS OF THE FRUIT ESSENTIAL OIL OF Chrysophyllum cainito (INDIA STAR APPLE)

Ogunmola¹,

Bolaji²,

Sodamade³

2015

SBJCHEM

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Chrysophyllum cainito is a lesser-known fruit with several medicinal applications. The essential oil was obtained by hydrodistillation and was analyzed by gas chromatography/mass spectrometry, GC/GC-MS. Twenty components were identified in the essential oil, the oil was characterized by a high proportion of fatty acids (69.37%) represented by pyruvic acid, 10-hendecenoic acid, E-9-tetradecenoic acid, pentadecanoic acid, hexodecacanoic acid, and cis-9-octadecenoic acid. The oil yield was 0.19 v/w of the wet sample and its compositional profile showed markedly qualitative and quantitative variation with essential oil from Cuba. This essential oil was seen to be active against gram-positive bacteria, Escherichia coli, Klebsiella pneumoniae, Samonella typhimurium, and Proteus mirabilis, and also gram-negative bacteria, Staphylococcus aureus, and Streptococcus agalactia.

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“…[7][8][9] A análise por cromatografia em camada delgada (CCD) utilizando β-caroteno como revelador tem sido amplamente empregada na detecção de produtos naturais com propriedade antioxidante. [10][11][12][13][14] Esta técnica apresenta muitas vantagens como a fácil execução e compreensão, simplicidade, versatilidade e baixo custo.…”

Section: Introductionunclassified

Extração de β-caroteno de cenouras: uma proposta para disciplinas experimentais de química

Zeraik¹,

Yariwake²

2008

Quím. Nova

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Chemical study of leaves of Chrysophyllum marginatum (Hook. & Arn.) Radlk (Sapotaceae)

Cited by 5 publications

References 8 publications

Phenolic Constituents of Chrysophyllum oliviforme L. Leaf Down-Regulate TGF-β Expression and Ameliorate CCl4-Induced Liver Fibrosis: Evidence from In Vivo and In Silico Studies

Phenolic Constituents of Chrysophyllum oliviforme L. Leaf Down-Regulate TGF-β Expression and Ameliorate CCl4-Induced Liver Fibrosis: Evidence from In Vivo and In Silico Studies

THE CHEMICAL AND MEDICINAL POTENTIALS OF THE FRUIT ESSENTIAL OIL OF Chrysophyllum cainito (INDIA STAR APPLE)

Extração de β-caroteno de cenouras: uma proposta para disciplinas experimentais de química

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