Inclusion complex of the antiviral drug acyclovir with cyclodextrin in aqueous solution and in solid phase

Abstract

Complexation between acyclovir (ACV), an antiviral drug used for the treatment of herpes simplex virus infection, and beta-cyclodextrin (beta-CD) was studied in solution and in solid states. Complexation in solution was evaluated using solubility studies and nuclear magnetic resonance spectroscopy (¹H-NMR). In the solid state, X-ray diffraction, differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA) and dissolution studies were used. Solubility studies suggested the existence of a 1:1 complex between ACV and beta-CD. ¹H-NMR spectroscopy studies showed that the complex formed occurs with a stoichiometry ratio of 1:1. Powder X-ray diffraction indicated that ACV exists in a semicrystalline state in the complexed form with beta-CD. DSC studies showed the existence of a complex of ACV with beta-CD. The TGA studies confirmed the DSC results of the complex. Solubility of ACV in solid complexes was studied by the dissolution method and it was found to be much more soluble than the uncomplexed drug

Micellar behavior of aqueous solutions of dodecyldimethylethylammonium bromide, dodecyltrimethylammonium chloride and tetradecyltrimethylammonium chloride in the presence of α-, β-, HPβ- and γ-cyclodextrins

“…Accommodation of the guest molecule depends on its size and polarity and on the size of the particular cyclodextrin. CDs, as a result of their complexation ability and other versatile characteristics, are continuing to have different applications in different areas of drug delivery and pharmaceutical industry [1][2][3][4][5][6][7][8][9][10][11][12][13].…”

Energetically favorable interactions between diclofenac sodium and cyclodextrin molecules in aqueous media

“…Cyclodextrins (nontoxic macrocyclic sugars) are well known in supramolecular chemistry as the most efficient molecular hosts [1][2][3][4][5][6] capable of encapsulating, with a degree of selectivity, a range of guest molecules via noncovalent interactions in hydrophobic cavities. The sequestration of a hydrophobic molecule or some part of it, inside the cavity usually alters the physicochemical properties of the encapsulated molecule, which is protected against the aqueous medium from light, oxidants or reactive attacks.…”

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“…However, drug with polymer endothermic peak shown at 246.74°C, which may be due to decreased crystalline behavior of drug to amorphous state during mixing with polymer such as Carbopol 934 was reported. [17,18] …”