The present essay is aimed at getting the radiologist familiar with the basic
histological skin structure, allowing for a better correlation with sonographic
findings. A high-frequency (22 MHz) ultrasonography apparatus was utilized in the
present study. The histological analysis was performed after the skin specimens
fixation with formalin, inclusion in paraffin blocks and subsequent staining with
hematoxylin-eosin. The authors present a literature review showing the relationship
between sonographic and histological findings in normal cutaneous tissue, and discuss
the technique for a better performance of the sonographic scan. High-frequency
ultrasonography is an excellent tool for the diagnosis of different skin conditions.
However, as this method is operator-dependent, it is crucial to understand the normal
skin structure as well as the correlation between histological and sonographic
findings.