Antioxidant protection of statins in acute kidney injury induced by sepsis

Santos, Franciele do Nascimento; Watanabe, Mirian; Vasco, Carolina Ferreira; Fonseca, Cassiane Dezoti da; Vattimo, Maria de Fátima Fernandes

doi:10.1590/s0080-6234201400005000007

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…Many studies have shown various statins effects e.g. decreasing levels of inflammatory cytokines ( Chu et al, 2012 ), restoring Neuronal nitric Oxide synthase (nNOS) expression ( Ii et al, 2005 ) and antioxidant effect ( Santos Fdo, Watanabe, Vasco, Fonseca, & Vattimo Mde, 2014 ); these effects might play important roles in pain improvement in neuropathic pain models. Proinflammatory cytokines such as IL-6, have been reported with their upregulating effect following nerve injury ( Lee, Lee, Son, Hwang, & Cho, 2004 ).…”

Section: Discussionmentioning

confidence: 99%

The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats

Hasanvand

Ahmadizar

Abbaszadeh

et al. 2018

BCN

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Introduction:According to studies, statins possess analgesics and anti-inflammatory properties. In the present study, we examined the antinociceptive, anti-inflammatory and antioxidative effects of rosuvastatin in an experimental model of Chronic Constriction Injury (CCI).Methods:Our study was conducted on four groups; sham, CCI (the control group), CCI+rosuvastatin (i.p. 5 mg/kg), and CCI+rosuvastatin (i.p. 10 mg/kg). We performed heat hyperalgesia, cold and mechanical allodynia tests on the 3rd, 7th, 14th, and 21st after inducing CCI. Blood samples were collected to measure the serum levels of Tumor Necrosis Factor (TNF)-α, and Interleukin (IL)-6. Rats’ spinal cords were also examined to measure tissue concentration of Malondialdehyde (MDA), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) enzymes.Results:Our findings showed that CCI resulted in significant increase in heat hyperalgesia, cold and mechanical allodynia on the 7th, 14th and 21st day. Rosuvastatin use attenuated the CCI-induced hyperalgesia and allodynia. Rosuvastatin use also resulted in reduction of TNF-α, IL-6, and MDA levels. However, rosuvastatin therapy increased the concentration of SOD and GPx in the CCI+Ros (5 mg/kg) and the CCI+Ros (10 mg/kg) groups compared to the CCI group.Conclusion:Rosuvastatin attenuated the CCI-induced neuropathic pain and inflammation. Thus, antinociceptive effects of rosuvastatin might be channeled through inhibition of inflammatory biomarkers and antioxidant properties.

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Section: Discussionmentioning

confidence: 99%

The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats

Hasanvand

Ahmadizar

Abbaszadeh

et al. 2018

BCN

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“…Wang et al demonstrated that the antioxidant therapy can reverse the glomerular filtration rate and the renal blood flow in sepsis-induced AKIs (29) . Additionally, Santos et al revealed that a preconditioning with statin for five days preserved the kidney function of animals submitted to sepsis through the CLP technique (30) . Another important flavonoid, resveratrol, exhibited a reduction effect on the activity of reactive nitrogen species, decreasing the redox imbalance in the sepsis experimental model (31) .…”

Section: Discussionmentioning

confidence: 99%

Sepsis-induced acute kidney injury: kidney protection effects by antioxidants

et al. 2018

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“…However, statins have a protective effect against AKI according to previous animal studies (4,5). By reducing serum cholesterol levels, statins reduce the risk of cardiovascular death (6).…”

Section: Introductionmentioning

confidence: 92%

Association of Prior to Intensive Care Unit Statin Use With Outcomes on Patients With Acute Kidney Injury

Tang

Cheng

et al. 2021

Front. Med.

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Purpose: To evaluate the association of prior to intensive care unit (ICU) statin use with the clinical outcomes in critically ill patients with acute kidney injury (AKI).Materials and Methods: Patients with AKI were selected from the Medical Information Mart for Intensive Care IV (version 1.0) database for this retrospective observational study. The primary outcome was 30-day intensive care unit (ICU) mortality. A 30-day in-hospital mortality and ICU length of stay (LOS) were considered as secondary outcomes. Comparison of mortality between pre-ICU statin users with non-users was conducted by the multivariate Cox proportional hazards model. Comparison of ICU LOS between two groups was implemented by multivariate linear model. Three propensity score methods were used to verify the results as sensitivity analyses. Stratification analyses were conducted to explore whether the association between pre-ICU statin use and mortality differed across various subgroups classified by sex and different AKI stages.Results: We identified 3,821 pre-ICU statin users and 9,690 non-users. In multivariate model, pre-ICU statin use was associated with reduced 30-day ICU mortality rate [hazard ratio (HR) 0.68 (0.59, 0.79); p < 0.001], 30-day in-hospital mortality rate [HR 0.64 (0.57, 0.72); p < 0.001] and ICU LOS [mean difference −0.51(−0.79, −0.24); p < 0.001]. The results were consistent in three propensity score methods. In subgroup analyses, pre-ICU statin use was associated with decreased 30-day ICU mortality and 30-day in-hospital mortality in both sexes and AKI stages, except for 30-day ICU mortality in AKI stage 1.Conclusion: Patients with AKI who were administered statins prior to ICU admission might have lower mortality during ICU and hospital stay and shorter ICU LOS.

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Antioxidant protection of statins in acute kidney injury induced by sepsis

Cited by 7 publications

References 25 publications

The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats

The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats

Sepsis-induced acute kidney injury: kidney protection effects by antioxidants

Association of Prior to Intensive Care Unit Statin Use With Outcomes on Patients With Acute Kidney Injury

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