Scientific production on the applicability of phenytoin in wound healing

Abstract

RESUmoA fenitoína é um anticonvulsivante que vem sendo empregado na cicatrização de ferida. Os objetivos desta pesquisa foram: descrever como a produção científica apresenta o uso da fenitoína como agente cicatrizante e discutir sua aplicabilidade em feridas. Foi realizada, para tanto, revisão integrativa da literatura e análise pela hierarquia das práticas baseadas em evidências. Assim, analisaram-se 18 artigos que testaram a intervenção em feridas como úlceras de perna, por hanseníase, pé diabético, úlceras por pressão, tróficas, ferimentos de guerra, queimaduras, preparo da área receptora de enxerto, radiodermites e pós-extração de nevos melanocíticos. Uso sistê-mico da fenitoína no tratamento de fístulas e a hipótese do uso tópico no tratamento do vitiligo foram achados. Conclui-se que a fenitoína tópica é uma evidência científica. No entanto necessita-se de pesquisas robustas que sustentem o uso protocolar da fenitoína como mais uma opção de agente cicatrizante na prática clínica. Scientific production on the applicability of phenytoin in wound healing * CritiCal review AbStRActPhenytoin is an anticonvulsant that has been used in wound healing. The objectives of this study were to describe how the scientific production presents the use of phenytoin as a healing agent and to discuss its applicability in wounds. A literature review and hierarchy analysis of evidence-based practices was performed.Eighteen articles were analyzed that tested the intervention in wounds such as leprosy ulcers, leg ulcers, diabetic foot ulcers, pressure ulcers, trophic ulcers, war wounds, burns, preparation of recipient graft area, radiodermatitis and post-extraction of melanocytic nevi. Systemic use of phenytoin in the treatment of fistulas and the hypothesis of topical use in the treatment of vitiligo were found. In conclusion, topical use of phenytoin is scientifically evidenced. However robust research is needed that supports a protocol for the use of phenytoin as another option of a healing agent in clinical practice. dEScRiPtoRS Phenytoin Wound healing Evidence-based nursing Review RESUmEnLa fenitoína es un anticonvulsivo que se utiliza en la cicatrización de heridas. Los objetivos de esta investigación fueron: describir cómo la producción científica presenta el uso de la fenitoína como agente cicatrizante y discutir su aplicabilidad en las heridas. Se realizó una revisión integradora de la literatura y el análisis por la jerarquía de las prácticas basadas en las evidencias. Se analizaron 18 artículos que probaron la intervención en heridas como úlceras en la pierna por hanseniasis, pie diabético, úlceras por presión, tróficas, heridas de guerra, quemadura, preparación de la zona a injertar, radiodermitis y post extracción de nevos melanocíticos. Se encontró el uso sistémico de la fenitoína en el tratamiento de fístulas y la hipótesis del uso tópico en el tratamiento del vitíligo. Se concluye que la fenitoína tópica es una evidencia científica. Sin embargo, se necesita de investigaciones sólidas que sustenten el uso protocola...

Topical Application of Teucrium polium Can Improve Wound Healing in Diabetic Rats

“…22 However, in this regard the effectiveness of local phenytoin ointment has been proposed due to its increased granulation tissue, angiogenesis, and decreasing of wound size. 23,24 In the current investigation involving excision wound models in diabetic rats various observation of physical and histological factors demonstrated the wound healing activity of the ethanolic extract of T. polium. Alloxan administration caused a significant increase in blood glucose level in laboratory animals.…”

Evidências científicas sobre as úlceras de pernas como sequela da hanseníase

“…(31) In another study it points out the advances of this therapy although it is little used in the services that attend people with ulcers resulting from leprosy. (32) In 2008, the publication comparing the biomembrane of vegetable latex and products based on Essential Fatty Acids (EFA) in lesions infected and recurrent leprosy showed that EFA showed positive antimicrobial effect for Enterobacter aerogenes and latex biomembrane on Pseudomonas aeruginosa. (25) This membrane is impermeable, has a vascular endothelial growth factor, has antigenic properties and accelerates the formation of granulation tissue.…”

Re-evaluation of the first phenytoin paste healing effects on oral biopsy ulcers

“…Previous studies demonstrated the anti-inflammatory effect of phenytoin. [ 23 24 25 ] It seems that in acute wounds, the effects of topical phenytoin is more pronounced in a few days after onset of lesion when the natural healing process has not been reached its optimum effect yet.…”