Why do we need alternative tools to control mosquito-borne diseases in Latin America?

Maciel-de-Freitas, Rafael; Aguiar, Raquel; Bruno, Rafaela Vieira; Guimarães, Maria Cristina Soares; Lourenço‐de‐Oliveira, Ricardo; Sorgine, Marcos Hf; Struchiner, Cláudio J.; Valle, Denise; O'Neill, Scott Leslie; Moreira, Luciano Andrade

doi:10.1590/s0074-02762012000600021

Cited by 44 publications

(29 citation statements)

References 2 publications

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“…The most critical epidemiological situation is that described for South America, which reported more than 1.5 million dengue cases in 2013, with an incidence rate of more than 650 cases/100,000 inhabitants in the South Cone alone (6). Such an epidemiological scenario points to the weakness of mosquito control activities and the high receptivity to introduction and spread of other arboviruses transmitted by both mosquito species like CHIKV in other parts of the continent (1,7,8). In fact, as CHIKV and DENV share the same mosquito vector species, epidemic waves caused by both viruses affect the same regions, and human coinfections may occur (9,10).…”

Section: Hikungunya Virus (Chikv) Is An Alphavirus In the Familymentioning

confidence: 99%

High Level of Vector Competence of Aedes aegypti and Aedes albopictus from Ten American Countries as a Crucial Factor in the Spread of Chikungunya Virus

Vega-Rúa

Zouache

Girod

et al. 2014

J Virol

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380

357

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Chikungunya virus (CHIKV) causes a major public health problem. In 2004, CHIKV began an unprecedented global expansion and has been responsible for epidemics in Africa, Asia, islands in the Indian Ocean region, and surprisingly, in temperate regions, such as Europe. Intriguingly, no local transmission of chikungunya virus (CHIKV) had been reported in the Americas until recently, despite the presence of vectors and annually reported imported cases. Here, we assessed the vector competence of 35 American Aedes aegypti and Aedes albopictus mosquito populations for three CHIKV genotypes. We also compared the number of viral particles of different CHIKV strains in mosquito saliva at two different times postinfection. Primarily, viral dissemination rates were high for all mosquito populations irrespective of the tested CHIKV isolate. In contrast, differences in transmission efficiency (TE) were underlined in populations of both species through the Americas, suggesting the role of salivary glands in selecting CHIKV for highly efficient transmission. Nonetheless, both mosquito species were capable of transmitting all three CHIKV genotypes, and TE reached alarming rates as high as 83.3% and 96.7% in A. aegypti and A. albopictus populations, respectively. A. albopictus better transmitted the epidemic mutant strain CHIKV_0621 of the East-Central-South African (ECSA) genotype than did A. aegypti, whereas the latter species was more capable of transmitting the original ECSA CHIKV_115 strain and also the Asian genotype CHIKV_NC. Therefore, a high risk of establishment and spread of CHIKV throughout the tropical, subtropical, and even temperate regions of the Americas is more real than ever.

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Section: Hikungunya Virus (Chikv) Is An Alphavirus In the Familymentioning

confidence: 99%

High Level of Vector Competence of Aedes aegypti and Aedes albopictus from Ten American Countries as a Crucial Factor in the Spread of Chikungunya Virus

Vega-Rúa

Zouache

Girod

et al. 2014

J Virol

Self Cite

380

357

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“…Dengue has spread widely in urban areas of tropical and subtropical regions during the last decades, including countries of Southeast Asia, Pacific and Latin America [1]. Between 2001–2011, almost 10 million dengue cases were reported in Latin America, almost 60% of these were registered in Brazil [2]. Dengue mortality can reach up to 5% of the confirmed infection cases.…”

Section: Introductionmentioning

confidence: 99%

Distribution and dissemination of the Val1016Ile and Phe1534Cys Kdr mutations in Aedes aegypti Brazilian natural populations

et al. 2014

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BackgroundThe chemical control of the mosquito Aedes aegypti, the major vector of dengue, is being seriously threatened due to the development of pyrethroid resistance. Substitutions in the 1016 and 1534 sites of the voltage gated sodium channel (AaNaV), commonly known as kdr mutations, confer the mosquito with knockdown resistance. Our aim was to evaluate the allelic composition of natural populations of Brazilian Ae. aegypti at both kdr sites.MethodsThe AaNaV IIIS6 region was cloned and sequenced from three Brazilian populations. Additionally, individual mosquitoes from 30 populations throughout the country were genotyped for 1016 and 1534 sites, based in allele-specific PCR. For individual genotypes both sites were considered as a single locus.ResultsThe 350 bp sequence spanning the IIIS6 region of the AaNa V gene revealed the occurrence of the kdr mutation Phe1534Cys in Brazil. Concerning the individual genotyping, beyond the susceptible wild-type (NaVS), two kdr alleles were identified: substitutions restricted to the 1534 position (NaVR1) or simultaneous substitutions in both 1016 and 1534 sites (NaVR2). A clear regional distribution pattern of these alleles was observed. The NaVR1kdr allele occurred in all localities, while NaVR2 was more frequent in the Central and Southeastern localities. Locations that were sampled multiple times in the course of a decade revealed an increase in frequency of the kdr mutations, mainly the double mutant allele NaVR2. Recent samples also indicate that NaVR2 is spreading towards the Northern region.ConclusionsWe have found that in addition to the previously reported Val1016Ile kdr mutation, the Phe1534Cys mutation also occurs in Brazil. Allelic composition at both sites was important to elucidate the actual distribution of kdr mutations throughout the country. Studies to determine gene flow and the fitness costs of these kdr alleles are underway and will be important to better understand the dynamics of Ae. aegypti pyrethroid resistance.

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“…Modulation of mosquito transmission by the introduction of endosymbiotic Wolbachia spp. bacteria, which suppress the replication of some arboviruses, holds promise for reducing urban transmission of DENV, YFV, and CHIKV [11]. However, it is unknown if this approach could be applied to the more diverse enzootic vectors that are poorly understood.…”

mentioning

confidence: 99%

Urbanization and geographic expansion of zoonotic arboviral diseases: mechanisms and potential strategies for prevention

Weaver¹

2013

Trends in Microbiology

187

155

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Why do we need alternative tools to control mosquito-borne diseases in Latin America?

Cited by 44 publications

References 2 publications

High Level of Vector Competence of Aedes aegypti and Aedes albopictus from Ten American Countries as a Crucial Factor in the Spread of Chikungunya Virus

High Level of Vector Competence of Aedes aegypti and Aedes albopictus from Ten American Countries as a Crucial Factor in the Spread of Chikungunya Virus

Distribution and dissemination of the Val1016Ile and Phe1534Cys Kdr mutations in Aedes aegypti Brazilian natural populations

Urbanization and geographic expansion of zoonotic arboviral diseases: mechanisms and potential strategies for prevention

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