Aggregative adherent strains of Corynebacterium pseudodiphtheriticum enter and survive within HEp-2 epithelial cells

Souza, Monica Cristina de; Santos, Louisy Sanches dos; Gomes, Débora Leandro Rama; Sabbadini, Priscila Soares; Santos, Cinta Silva dos; Camello, Thereza Cristina Ferreira; Asad, L.M.B.O.; Rosa, Ana Cláudia P.; Nagao, Prescilla Emy; Júnior, Raphael Hirata; Guaraldi, Ana Luíza de Mattos

doi:10.1590/s0074-02762012000400008

Cited by 8 publications

(3 citation statements)

References 38 publications

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“…In an experimental study, Souza et al, found that C. pseudodiphtheriticum can invade and survive within HEp-2 cells. [7] They explained some mechanisms, which may be relevant for in vivo infections, allowing C. pseudodiphtheriticum to breach the epithelial cell barrier and enter deeper tissues. They also suggested epithelial cell attachment as an essential step for dissemination of some strains throughout the respiratory tract and to other sites in human body.…”

Section: Case Reportmentioning

confidence: 99%

“…[8,9] Other rarely reported infections caused by this organism include keratitis and conjunctivitis, septic arthritis, suppurative lymphadenitis, cutaneous infection and genitourinary infection. [7] Being an emerging pathogen for humans, routine screening for C. pseudodiphtheriticum should be employed for clinical samples of patients with diphtheria-like presentation. Special measures are needed to control dissemination of diphtheria.…”

Section: Case Reportmentioning

confidence: 99%

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Diphtheria-like illness in a fully immunised child caused by Corynebacterium pseudodiphtheriticum

Indumathi

Suryaprakash

2014

Indian Journal of Medical Microbiology

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Corynebacterium pseudodiphtheriticum is a common commensal flora of the upper respiratory tract in humans. Though the pathogenicity of C. pseudodiphtheriticum is not rare, its role as an opportunistic pathogen is mainly limited to the lower respiratory tract, particularly in patients with underlying systemic conditions or immune-compromisation. We hereby present the first case of C. pseudodiphtheriticum causing diphtheria-like illness affecting the upper respiratory tract of a 6-year-old fully immunised otherwise healthy child. In countries with very low incidence of diphtheria, C. pseudodiphtheriticum should be included in differential diagnosis for a child presenting with diphtheria-like illness. Simple, rapid screening tests should be used to differentiate it from C. diphtheriae and hence, to prevent unnecessary concern in community.

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Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Diphtheria-like illness in a fully immunised child caused by Corynebacterium pseudodiphtheriticum

Indumathi

Suryaprakash

2014

Indian Journal of Medical Microbiology

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“…As a first step towards a better understanding of the host-pathogen interaction process, the colonization of epithelial cells was investigated. 31 C.…”

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confidence: 99%

Corynebacterium pseudodiphtheriticum: Putative probiotic, opportunistic infector, emerging pathogen

Burkovski

2015

Virulence

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Non-diphtheriae Corynebacterium species: an emerging respiratory pathogen

Díez-Aguilar

Ruíz-Garbajosa

Fernández-Olmos

et al. 2012

Eur J Clin Microbiol Infect Dis

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The purpose of the study was to describe the microbiological and clinical features of ten cases of lower respiratory tract infection due to Corynebacterium striatum, Corynebacterium propinquum and Corynebacterium pseudodiphtheriticum. Respiratory samples were recovered from hospitalised patients who were diagnosed of pneumonia and exacerbations of chronic respiratory infections. The samples were Gram-stained and seeded on conventional bacterial growing media. Bacteria were identified by matrix-assisted linear desorption/ionisation-time-of-flight mass spectrometry (MALDI-TOF MS). Antibiotic susceptibility was tested by the disk diffusion method. All patients presented an acute respiratory onset, most of them in the context of an underlying disease and/or immunosuppression. In all patients, the microscopical examination of Gram-stained respiratory samples showed numerous polymorphonuclear cells and Gram-positive bacilli, suggestive of the Corynebacterium morphotype. A pure culture growth of Corynebacterium was obtained in the majority (72 %) of samples. The conclusions are that non-diphtheriae Corynebacterium species are an emerging cause of respiratory infection among patients with chronic respiratory disease and/or immunosuppression, and cannot always be considered as mere colonisers. The microorganism's predominance in Gram-stained purulent respiratory samples together with abundant growth in the culture is the key for the microbiological diagnosis.

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Aggregative adherent strains of Corynebacterium pseudodiphtheriticum enter and survive within HEp-2 epithelial cells

Cited by 8 publications

References 38 publications

Diphtheria-like illness in a fully immunised child caused by Corynebacterium pseudodiphtheriticum

Diphtheria-like illness in a fully immunised child caused by Corynebacterium pseudodiphtheriticum

Corynebacterium pseudodiphtheriticum: Putative probiotic, opportunistic infector, emerging pathogen

Non-diphtheriae Corynebacterium species: an emerging respiratory pathogen

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