HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population

Monteiro, Sergio Pereira; Brasil, Pedro Emmanuel Alvarenga Americano do; Cabello, Giselda M. K.; Souza, Rogério Valls de; Brasil, Patrícia; Georg, Ingebourg; Cabello, Pedro Hernán; Castro, L. de

doi:10.1590/s0074-02762012000200012

Cited by 21 publications

(12 citation statements)

References 41 publications

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“…HLA A*24 is associated with susceptibility to disease not only in secondary, but also in primary infections with DENV (22,24), and a recent report associated HLA A*01 with susceptibility to DHF in a Brazilian population (43). In contrast, B*3501 was negatively associated with symptomatic disease in Mexican dengue fever patients (25), and one study reported that HLA A and not HLA B genes are associated with DHF (22).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8 ⁺ T cells

Weiskopf

Angelo

Azeredo

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

508

645

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The role of CD8 + T cells in dengue virus infection and subsequent disease manifestations is not fully understood. According to the original antigenic sin theory, skewing of T-cell responses induced by primary infection with one serotype causes less effective response upon secondary infection with a different serotype, predisposing individuals to severe disease. A comprehensive analysis of CD8 + responses in the general population from the Sri Lankan hyperendemic area, involving the measurement of ex vivo IFNγ responses associated with more than 400 epitopes, challenges the original antigenic sin theory. Although skewing of responses toward primary infecting viruses was detected, this was not associated with impairment of responses either qualitatively or quantitatively. Furthermore, we demonstrate higher magnitude and more polyfunctional responses for HLA alleles associated with decreased susceptibility to severe disease, suggesting that a vigorous response by multifunctional CD8 + T cells is associated with protection from dengue virus disease.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8 ⁺ T cells

Weiskopf

Angelo

Azeredo

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

508

645

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“…However, very few of these have been replicated in different populations except HLA-AÃ24, which was found to be a risk factor for developing severe dengue in Vietnam [50], and also Malaysia [49]. In the past year HLA-AÃ01 allele has been identified as a risk factor for DHF in Brazil [51].…”

Section: Host Genetic Determinantsmentioning

confidence: 99%

The pathogenesis of dengue

Yacoub

Mongkolsapaya

Screaton

2013

Current Opinion in Infectious Diseases

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“…The outcome of autoimmune and infectious diseases, as well as cancer, is associated with some HLA alleles . For instance, the HLA‐A*74:01 allele is associated with protection against HIV‐1 infection and slow progression to AIDS (acquired immunodeficiency syndrome) .…”

Section: Introductionmentioning

confidence: 99%

“…6,7 The outcome of autoimmune and infectious diseases, as well as cancer, is associated with some HLA alleles. [8][9][10][11][12][13] For instance, the HLA-A*74:01 allele is associated with protection against HIV-1 infection and slow progression to AIDS (acquired immunodeficiency syndrome). 14 Although the mechanism underlying the association between HLA alleles and infectious diseases has not been completely elucidated, the capacity of an HLA molecule to bind peptides depends on the structure of the peptide-binding groove, and of the presented pathogen peptide.…”

Section: Introductionmentioning

confidence: 99%

HLA‐A promoter, coding, and 3′UTR sequences in a Brazilian cohort, and their evolutionary aspects

Souza

Porto

Paz

et al. 2019

HLA

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HLA‐A is the second most polymorphic locus of the human leucocyte antigen (HLA) complex encoding a key molecule for antigen presentation and NK cell modulation. Many studies have evaluated HLA‐A variability in worldwide populations, focusing mainly on exons, but the regulatory segments have been poorly characterized. HLA‐A variability is particularly high in the segment encoding the peptide‐binding groove (exons 2 and 3), which is related to the antigen presentation function and the balancing selection in these segments. Here we evaluate the genetic diversity of the HLA‐A gene considering a continuous segment encompassing the extended promoter (1.5 kb upstream of the first translated ATG), all exons and introns, and the entire 3′ untranslated region, by using massively parallel sequencing. To achieve this goal, we used a freely available bioinformatics workflow that optimizes read mapping for HLA genes and defines complete sequences using either the phase among variable sites directly observed in sequencing data and probabilistic models. The HLA‐A variability detected in a highly admixed population sample from Brazil shows that the HLA‐A regulatory segments present few, but divergent sequences. The regulatory segments are in close association with the coding alleles. Both exons and introns are highly variable. Moreover, patterns of molecular diversity suggest that the promoter, in addition to the coding region, might be under the same selective pressure, but a different scenario arises when it comes to exon 4 and the 3′UTR segment.

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HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population

Cited by 21 publications

References 41 publications

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8 ⁺ T cells

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8 ⁺ T cells

The pathogenesis of dengue

HLA‐A promoter, coding, and 3′UTR sequences in a Brazilian cohort, and their evolutionary aspects

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HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population

Cited by 21 publications

References 41 publications

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8 + T cells

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8 + T cells

The pathogenesis of dengue

HLA‐A promoter, coding, and 3′UTR sequences in a Brazilian cohort, and their evolutionary aspects

Contact Info

Product

Resources

About

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8 ⁺ T cells

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8 ⁺ T cells