The pathogenesis of dengue

Yacoub, Sophie; Mongkolsapaya, Juthathip; Screaton, Gavin

doi:10.1097/qco.0b013e32835fb938

Cited by 64 publications

(52 citation statements)

References 55 publications

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“…It is remarkable that so much dengue pathogenesis research effort over the past 45 years has focused on mechanisms that address only sequential DENV and ignore primary DHF/DSS infection in infants. These mechanisms, exaggerated or abnormal T cell responses, and autoimmune responses evoked by DENV antigens are well described in many reviews (89)(90)(91). During the decade of the 1970s, several experimental observations led to an explanatory hypothesis that was able to accommodate both groups of cases.…”

Section: Dengue Pathogenesis: Looking To the Futurementioning

confidence: 99%

Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment

Halstead

Cohen

2015

Microbiol Mol Biol Rev

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SUMMARY During the decade of the 1960s, the epidemiology of a new dengue disease, dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS), was described by collaborative research performed by Thai scientists from many institutions and by workers at the U.S. Army's SEATO Medical Research Laboratory in Bangkok, Thailand. Careful clinical and physiological studies provided the initial description of DSS. DSS cases were caused by each of the four dengue viruses (DENV) and not chikungunya (CHIK) virus or DENV 5 and 6, were associated with a secondary-type dengue antibody response in children over the age of 1 year, were associated with a primary antibody response in infants less than 1 year old whose mothers had neutralizing antibodies to all four DENV, were associated more frequently with secondary DENV 2 infections than those due to DENV 1 and 3, and were more common in females than males over the age of 3 years. Robust laboratory methods for growth and recovery of DENV in tissue cultures were introduced. In addition, life-saving principles of fluid and plasma protein resuscitation of hypovolemia were described. Most epidemiological observations made during the decade of the 1960s have been confirmed in the succeeding 45 years. Much contemporary research on pathogenesis fails to address the two distinct immunological antecedents of DHF/DSS.

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Section: Dengue Pathogenesis: Looking To the Futurementioning

confidence: 99%

Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment

Halstead

Cohen

2015

Microbiol Mol Biol Rev

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“…Four distinct serotypes of DENV exist (DENV1-4; 65% conservation 1 ), each capable of causing disease following transmission by the arthropod vectors Aedes aegypti or Aedes albopictus. [2][3][4] Although the large majority of primary infections are asymptomatic, DENV infections can cause a flu-like illness characterized by fever, fatigue, muscle pains, and rash and, in a small proportion of infected individuals, a severe form of disease called dengue hemorrhagic fever. 2,3 Immunological memory protects individuals from reinfection with the same but not distinct serotypes and the more severe forms of disease most often occur during secondary infection with a different serotype.…”

Section: Introductionmentioning

confidence: 99%

Dengue virus specific dual HLA binding T cell epitopes induce CD8⁺T cell responses in seropositive individuals

Comber

Karabudak

Huang

et al. 2014

Human Vaccines & Immunotherapeutics

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Dengue virus infects an estimated 300 million people each year and even more are at risk of becoming infected as the virus continues to spread into new areas. Despite the increase in viral prevalence, no anti-viral medications or vaccines are approved for treating or preventing infection. CD8C T cell responses play a major role in viral clearance. Therefore, effective vaccines that induce a broad, multi-functional T cell response with substantial cross-reactivity between all virus serotypes can have major impacts on reducing infection rates and infection related complications. Here, we took an immunoproteomic approach to identify novel MHC class I restricted T cell epitopes presented by dengue virus infected cells, representing the natural and authentic targets of the T cell response. Using this approach we identified 4 novel MHC-I restricted epitopes: 2 with the binding motif for HLA-A24 molecules and 2 with both HLA-A2 and HLA-A24 binding motifs. These peptides were able to activate CD8 C T cell responses in both healthy, seronegative individuals and in seropositive individuals who have previously been infected with dengue virus. Importantly, the dual binding epitopes activated pre-existing T cell precursors in PBMCs obtained from both HLA-A2 C and HLA-A24 C seropositive individuals. Together, the data indicate that these epitopes are immunologically relevant T cell activating peptides presented on infected cells during a natural infection and therefore may serve as candidate antigens for the development of effective multi-serotype specific dengue virus vaccines.

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“…(4) Plasma leakage usually occurs when fever is decreased in the critical phase and reaches its peak on the fifth day after the onset of fever. (5)(6)(7) In the critical phase, plasma leakage can lead to worse conditions that can cause shock and death. Since plasma leakage is the main characteristic of DHF or dengue shock syndrome (DSS), it will be a great indicator for determining DHF severity.…”

Section: Introductionmentioning

confidence: 99%

Serum lactate as predictor and diagnostic biomarker of plasma leakage in adult dengue patients

Bur

Suwarto

Santoso

et al. 2016

UnivMed

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BACKGROUNDDengue fever (DF) and dengue hemorrhagic fever (DHF) are differentiated by the occurrence in DHF of plasma leakage into the interstitial space as shown by pleural and peritoneal effusion, hemoconcentration, and intravascular hypovolemia. Perfusion dysfunction causes anaerobic metabolism, which leads to increased serum lactate. This study was to determine serum lactate as prognostic predictor and diagnostic biomarker of plasma leakage in adult dengue patients.

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The pathogenesis of dengue

Cited by 64 publications

References 55 publications

Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment

Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment

Dengue virus specific dual HLA binding T cell epitopes induce CD8⁺T cell responses in seropositive individuals

Serum lactate as predictor and diagnostic biomarker of plasma leakage in adult dengue patients

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The pathogenesis of dengue

Cited by 64 publications

References 55 publications

Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment

Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment

Dengue virus specific dual HLA binding T cell epitopes induce CD8+T cell responses in seropositive individuals

Serum lactate as predictor and diagnostic biomarker of plasma leakage in adult dengue patients

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Dengue virus specific dual HLA binding T cell epitopes induce CD8⁺T cell responses in seropositive individuals