Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis

Dias, Alyria Teixeira; Castro, Sandra Bertelli Ribeiro de; Alves, Caio César de Souza; Rezende, Alice Belleigoli; Rodrigues, Michele Fernandes; Machado, Rachel Rocha Pinheiro; Fernandes, André Almeida; Corrêa, Deborah Negrão; Teixeira, Henrique Couto; Ferreira, Ana Paula

doi:10.1590/s0074-02762011000500015

Cited by 11 publications

(14 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mice with Mtb [80] or M. bovis BCG [81] and concomitant S. mansoni infections exhibited higher mycobacterial burdens in vivo compared to S. mansoni -uninfected mice, suggesting that helminth infections directly influence bacterial growth in these experimental settings. Similarly, mice infected with either Nippostrogylus brasiliensis [82] or Strongyloides venezuelensis [83] also demonstrated impaired bacterial control and higher bacterial burdens in the lungs. And a recent study has also demonstrated that mice co-infected with Heligmosomoides polygyrus bakeri and M. bovis BCG resulted in higher mycobacterial loads [84].…”

Section: Helminth - Tuberculosis Co-infectionmentioning

confidence: 99%

“…Another mechanism by which helminthes modulate the immune response to TB is by the production of TGFβ, that can mediate the suppression of Th1 responses in mice resulting in higher bacterial burdens and decreased delayed type hypersensitivity responses [84]. The third mechanism at play is a direct effect on T cells with decreased Th17 responses and increased expression of CTLA-4 [83]. Finally, the expression of arginase-1 during co-infections has been shown to mediate impaired Th1 responses to Mtb antigens and exacerbated pulmonary pathology [88].…”

Section: Helminth - Tuberculosis Co-infectionmentioning

confidence: 99%

See 1 more Smart Citation

Helminth-Tuberculosis Co-infection: An Immunologic Perspective

Babu

Nutman

2016

Trends in Immunology

111

135

View full text Add to dashboard Cite

Over 2 billion people worldwide are infected with helminths (worms). Similarly, infection with Mycobacterium tuberculosis (Mtb) occurs in over a third of the world's population, often with a great degree of geographical overlap with helminth infection. Interestingly, the responses induced by the extracellular helminths and those induced by the intracellular Mtb are often mutually antagonistic and, as a consequence, can result in impaired (or cross-regulated) host responses to either of the infecting pathogens. In this review, we outline the nature of the immune responses induced by infections with helminths and tuberculosis (TB) and then provide data from both experimental models and human studies that illustrate how the immune response engendered by helminth parasites modulates Mtb-specific responses in helminth-TB co-infection.

show abstract

Section: Helminth - Tuberculosis Co-infectionmentioning

confidence: 99%

Section: Helminth - Tuberculosis Co-infectionmentioning

confidence: 99%

Helminth-Tuberculosis Co-infection: An Immunologic Perspective

Babu

Nutman

2016

Trends in Immunology

111

135

View full text Add to dashboard Cite

show abstract

“…Interestingly, IL-4 and IL-10 deficiency was necessary to reverse the obstructing effect of H. polygyrus infection on the CD8 + T cell response toward Toxoplasma (Marple et al, 2017). The majority of co-infection studies despite being protozoan, viral or bacterial infection, have focused on infections with helminth first due to their ability to downmodulate immune responses (Rousseau et al, 1997; Liesenfeld et al, 2004; Chen et al, 2005, 2006; Graham et al, 2005; Su et al, 2005, 2014a,b; Weng et al, 2007; Khan et al, 2008; Noland et al, 2008; Miller et al, 2009; Frantz et al, 2010; Dias et al, 2011; Potian et al, 2011; Kolbaum et al, 2012; du Plessis et al, 2013; Osborne et al, 2014; Budischak et al, 2015; Coomes et al, 2015; Gondorf et al, 2015; Rafi et al, 2015; Obieglo et al, 2016). In light of the fact, that Th2 immunity against helminths is an ongoing challenge in humans and livestock, we aimed to investigate how a previous protozoan infection affects the development of Th2 responses in CD4 + T cells and protection against helminths.…”

Section: Introductionmentioning

confidence: 99%

Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response

Ahmed

French

Kühl³

et al. 2017

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Nematode infections, in particular gastrointestinal nematodes, are widespread and co-infections with other parasites and pathogens are frequently encountered in humans and animals. To decipher the immunological effects of a widespread protozoan infection on the anti-helminth immune response we studied a co-infection with the enteric nematode Heligmosomoides polygyrus in mice previously infected with Toxoplasma gondii. Protective immune responses against nematodes are dependent on parasite-specific Th2 responses associated with IL-4, IL-5, IL-13, IgE, and IgG1 antibodies. In contrast, Toxoplasma gondii infection elicits a strong and protective Th1 immune response characterized by IFN-γ, IL-12, and IgG2a antibodies. Co-infected animals displayed significantly higher worm fecundity although worm burden remained unchanged. In line with this, the Th2 response to H. polygyrus in co-infected animals showed a profound reduction of IL-4, IL-5, IL-13, and GATA-3 expressing T cells. Co-infection also resulted in the lack of eosinophilia and reduced expression of the Th2 effector molecule RELM-β in intestinal tissue. In contrast, the Th1 response to the protozoan parasite was not diminished and parasitemia of T. gondii was unaffected by concurrent helminth infection. Importantly, H. polygyrus specific restimulation of splenocytes revealed H. polygyrus-reactive CD4+ T cells that produce a significant amount of IFN-γ in co-infected animals. This was not observed in animals infected with the nematode alone. Increased levels of H. polygyrus-specific IgG2a antibodies in co-infected mice mirrored this finding. This study suggests that polarization rather than priming of naive CD4+ T cells is disturbed in mice previously infected with T. gondii. In conclusion, a previous T. gondii infection limits a helminth-specific Th2 immune response while promoting a shift toward a Th1-type immune response.

show abstract

“…In terms of interaction in human TB, filarial infections have been shown to alter the antigen - specific protective immune responses in latent TB by modulating the Th1 and Th17 responses to TB antigens [8]. In addition, Strongyloides has been shown to alter the protective Th17 cytokine responses in animal models of co-infection [9]. Finally, helminth infections are strongly associated with an IL-10 dominant regulatory environment that could potentially down modulate antigen - specific responses to third party antigens [10].…”

Section: Introductionmentioning

confidence: 99%

Helminth Infections Coincident with Active Pulmonary Tuberculosis Inhibit Mono- and Multifunctional CD4+ and CD8+ T Cell Responses in a Process Dependent on IL-10

et al. 2014

View full text Add to dashboard Cite

Tissue invasive helminth infections and tuberculosis (TB) are co-endemic in many parts of the world and can trigger immune responses that might antagonize each other. We have previously shown that helminth infections modulate the Th1 and Th17 responses to mycobacterial-antigens in latent TB. To determine whether helminth infections modulate antigen-specific and non-specific immune responses in active pulmonary TB, we examined CD4+ and CD8+ T cell responses as well as the systemic (plasma) cytokine levels in individuals with pulmonary TB with or without two distinct helminth infections—Wuchereria bancrofti and Strongyloides stercoralis infection. By analyzing the frequencies of Th1 and Th17 CD4+ and CD8+ T cells and their component subsets (including multifunctional cells), we report a significant diminution in the mycobacterial–specific frequencies of mono- and multi–functional CD4+ Th1 and (to a lesser extent) Th17 cells when concomitant filarial or Strongyloides infection occurs. The impairment in CD4+ and CD8+ T cell cytokine responses was antigen-specific as polyclonal activated T cell frequencies were equivalent irrespective of helminth infection status. This diminution in T cell responses was also reflected in diminished circulating levels of Th1 (IFN-γ, TNF-α and IL-2)- and Th17 (IL-17A and IL-17F)-associated cytokines. Finally, we demonstrate that for the filarial co-infections at least, this diminished frequency of multifunctional CD4+ T cell responses was partially dependent on IL-10 as IL-10 blockade significantly increased the frequencies of CD4+ Th1 cells. Thus, co-existent helminth infection is associated with an IL-10 mediated (for filarial infection) profound inhibition of antigen-specific CD4+ T cell responses as well as protective systemic cytokine responses in active pulmonary TB.

show abstract

Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis

Cited by 11 publications

References 17 publications

Helminth-Tuberculosis Co-infection: An Immunologic Perspective

Helminth-Tuberculosis Co-infection: An Immunologic Perspective

Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response

Helminth Infections Coincident with Active Pulmonary Tuberculosis Inhibit Mono- and Multifunctional CD4+ and CD8+ T Cell Responses in a Process Dependent on IL-10

Contact Info

Product

Resources

About