First report of the blaOXA-58 gene in a clinical isolate of Acinetobacter baumannii in Rio de Janeiro, Brazil

High prevalence of blaOXA-23 in Acinetobacter spp. and detection of blaNDM-1 in A. soli in Cuba: report from National Surveillance Program (2010–2012)

“…The main mechanisms are fundamentally related to the production of acquired carbapenem-hydrolyzing class D β-lactamases (oxacillinases) of phylogenetic subgroups OXA-58, OXA-23, OXA-24/40 and OXA-143 and, less frequently, to the acquisition of carbapenem-hydrolyzing metallo-β-lactamases such as those of type IMP or VIM. In recent studies in Latin America, the presence of OXA-23 (Brazil, Argentina), OXA-24 (Mexico, Argentina) and OXA-58 (Chile, Bolivia) has been documented [23,24] , with OXA-23 being the most prevalent (63–87%), in contrast to the low frequencies of the other two oxacillinases [25–27] . A similar prevalence of class D carbapenemases was found in Asia-Pacific countries [28] .…”

Genetic Characterization of Plasmid-Borne bla OXA-58 in Distinct Acinetobacter Species

“…In contrast, bla OXA-58 has been rarely reported in this country, contrasting with the high frequency of this CHDL-encoding gene seen in neighboring countries, mainly in Argentina (4). To date, only six OXA-58-producing Acinetobacter species strains recovered from human (5–8) and environmental (9) sources have been reported in distinct Brazilian cities since the 90s (5–9). The diverse genetic structures surrounding bla OXA-58 documented worldwide (3, 10, 11) play a major role not only in the mobilization of this resistance determinant but also in driving its expression, decisively leading to the carbapenem resistance phenotype (3, 12).…”

Avaliação in vitro e in vivo de efeitos sinérgicos de antibacterianos para o tratamento de infecções por Acinetobacter baumannii multirresistentes produtoras de carbapenemases tipo OXA endêmicas no Brasil

“…importância clínica e ambiental (Scaife et al, 1995;Queenan & Bush, 2007 (Figueiredo, et al, 2011;Tian et al, 2011), OXA-182, que está restrito a Coréia do Sul (Kim et al, 2010), e mais recentemente uma nova variante foi identificada no Brasil (OXA-143), a qual tem sido restrita ao país com rápida disseminação nos principais centros urbanos (Higgins et al 2009;Antonio et al, 2011;Medeiros et al, 2011Mostachio et al, 2012) Antonio et al, 2008;Schimith Bier et al, 2010;Martins et al, 2009;Mostachio et al, 2009;Carvalho et al, 2009;Medeiros et al, 2010;Antonio et al, 2011;Figueiredo et al, 2011;Antonio et al 2011;Gionco et al, 2011Morais et al 2012) …”

“…O primeiro caso de A. baumannii produtor de OXA-58 foi reportado na França em 2003, onde disseminou rapidamente Poirel et al, 2005;Héritier et al, 2005b). Posteriormente, cepas OXA-58 positivas foram descritas na Austrália (Peleg et al, 2006), Reino Unido (Coelho et al, 2006), Argentina (Merkier et al, 2008), Grécia (Pournaras et al, 2006;Papa et al, 2009;Liakopoulos et al, 2012), China (Lu et al, 2009;Zhang et al,2010), Itália (Bertini et al, 2006;Ansaldi et al, 2011;Carretto et al, 2011), Turquia (Kulah et al, 2010), Brasil (Antonio et al, 2009;Figueiredo et al, 2011).…”

“…baumannii produtor de OXA-58, os quais foram identificados nos estados de São Paulo e Rio de Janeiro (Medeiros et al, 2010;Antonio et al, 2011;Figueiredo et al, 2011) (Lu et al, 2009;Lin et al, 2011), assim como em outros países asiáticos, como China e Coréia do Sul . Na Europa, isolados produtores de OXA-72 têm sido identificados na França (Barnaud, et al, 2010), Espanha (Candel et al, 2010), Croácia (Franolić-Kukina et al, 2011).…”