Studying nanotoxic effects of CdTe quantum dots in Trypanosoma cruzi

Vieira, Cecília Stahl; Almeida, Diogo B.; Thomaz, André A. de; Menna-Barreto, Rubem F.S.; Santos-Mallet, Jacenir Reis dos; César, Carlos L.; Gomes, Sérgio Bittencourt Varella; Feder, Denise

doi:10.1590/s0074-02762011000200007

Cited by 26 publications

(10 citation statements)

References 32 publications

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“…The presence of the nanoparticle could be observed inside the cytosolic vesicles and also on epimastigote surface. Stahl and co-workers (2011) also observed that parasites incubated with 2 μM CdTe QDs presented the integrity of cellular organelles such as mitochondria, nucleus, Golgi apparatus and plasma membrane similar to the untreated groups [70]. Such concentration was sufficient to label the epimastigotes and was not toxic, at least up to 72 h, reinforcing the possibility of several applications of QDs in these parasites.…”

Section: Qds Toxicity For Protozoamentioning

confidence: 86%

“…Previously, it was shown that 10 μg/mL CdTe QDs capped MPA and cysteamine was cytotoxic in PC12 cells (cell line derived from a pheochromocytoma of the rat adrenal medulla) [69], but this same work indicated a toxicity of non-capped CdTe at a concentration of 1 μg/mL [69]. CdTe QDs cytotoxicity have been studied in mammals and microorganisms such as bacteria, protozoa, fungi and viruses [10,13,50,59,70]. …”

Section: Qds’ Cytotoxicitymentioning

confidence: 99%

“…We found that nanoparticles at concentrations below 20 μM did not affect the integrity, motility and cell division of parasites [70]. Cell cycle assays demonstrated a dose-dependent increase in DNA fragmentation induced by the incubation with 2–200 μM CdTe QDs, also reduction in the percentage of DNA duplicated parasites.…”

Section: Qds Toxicity For Protozoamentioning

confidence: 99%

“…This raised the possibility that high concentrations of QDs on the parasite surface could lead to autophagy by an unknown pathway, a question that has not been answered yet. The observation of QDs in membrane vesicles and extensive changes in the plasma membrane near the flagellar pocket region suggests a membrane shedding, without any disorganization in the subpellicular microtubules cage [70]. Some membrane blebbing induced by QDs was also described in bacteria [59].…”

Section: Qds Toxicity For Protozoamentioning

confidence: 99%

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CdTe and CdSe Quantum Dots Cytotoxicity: A Comparative Study on Microorganisms

Gomes

Vieira

Almeida

et al. 2011

Sensors

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Quantum dots (QDs) are colloidal semiconductor nanocrystals of a few nanometers in diameter, being their size and shape controlled during the synthesis. They are synthesized from atoms of group II–VI or III–V of the periodic table, such as cadmium telluride (CdTe) or cadmium selenium (CdSe) forming nanoparticles with fluorescent characteristics superior to current fluorophores. The excellent optical characteristics of quantum dots make them applied widely in the field of life sciences. Cellular uptake of QDs, location and translocation as well as any biological consequence, such as cytotoxicity, stimulated a lot of scientific research in this area. Several studies pointed to the cytotoxic effect against micoorganisms. In this mini-review, we overviewed the synthesis and optical properties of QDs, and its advantages and bioapplications in the studies about microorganisms such as protozoa, bacteria, fungi and virus.

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Section: Qds Toxicity For Protozoamentioning

confidence: 86%

Section: Qds’ Cytotoxicitymentioning

confidence: 99%

Section: Qds Toxicity For Protozoamentioning

confidence: 99%

Section: Qds Toxicity For Protozoamentioning

confidence: 99%

See 2 more Smart Citations

CdTe and CdSe Quantum Dots Cytotoxicity: A Comparative Study on Microorganisms

Gomes

Vieira

Almeida

et al. 2011

Sensors

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“…Several studies suggest QD cytotoxicity to be due to photolysis or oxidation. Under oxidative and photolytic conditions, QD core-shell coatings have been found to be labile, degrading, and thus exposing potentially toxic "capping" material or intact core metalloid complexes or resulting in dissolution of the core complex to QD core metal components, e.g., Cd and Se [46]. The toxicity is associated with the cadmium, lead, or arsenic containing QDs.…”

Section: Toxicity Of Quantum Dotsmentioning

confidence: 99%

Applicability of Quantum Dots in Biomedical Science

Brkić¹

2018

Ionizing Radiation Effects and Applications

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Quantum dots (QDs) are novel class of inorganic fluorophore with superior photophysical properties. Superior optical properties are a promising alternative to organic dyes for fluorescence biomedical applications. These nanoparticles have size-tunable emission, strong light absorbance, and very high levels of brightness and photostability. Highly luminescent QDs are prepared by coating the core with another material, resulting in core-shell quantum dots that are more stable in various chemical environments. These core-shell QDs are hydrophobic and only organic soluble as prepared. Hydrophobic QDs are insoluble in aqueous solution and cannot be directly employed in biomedical applications. They are necessarily made water soluble by surface modifying them with various bifunctional surface ligands or caps to promote aqueous solubility and enhancing biocompatibility. To make them useful for biomedical applications, QDs need to be conjugated to biological molecules without disturbing the biological function of these molecules. Most of the current studies were designed to ask questions concerning the physicochemical properties of novel QD products, not QD toxicity per se. The potential toxicity of the QDs is a cause for concern because they are made of heavy metals. The limitation of heavy metal-containing QDs stimulates extensive research interests in exploring alternative strategies for the design of fluorescent nanocrystals with high biocompatibility.

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Physiological behavior of quantum dots

Chen

2012

WIREs Nanomed Nanobiotechnol

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Quantum dots (QDs) have shown great potentials in biomedical applications like bioimaging, sensors and diagnostics due to various advantages such as their robust fluorescence, remarkable photostability, large absorption cross section, and tunable fluorescence emission. The fate, behavior, metabolism, and toxicities of QDs are the primary aspects to be assessed before their bio-applications. Numerous studies concerning those aspects have been reported in the past years. However, only several reviews discussed the toxicities of QDs and various contradictory conclusions appear between these studies. In this review, the fate, metabolism, and behaviors of various QDs and crucial parameters that may determine their fate and behavior in vivo are discussed in depth. This review may provide insights for a better understanding of the biological impacts of QDs. We also propose several suggestions for how to develop QDs application in humans in the future.

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Studying nanotoxic effects of CdTe quantum dots in Trypanosoma cruzi

Abstract: Semiconductor nanoparticles, such as quantum dots (QDs)

Cited by 26 publications

References 32 publications

CdTe and CdSe Quantum Dots Cytotoxicity: A Comparative Study on Microorganisms

CdTe and CdSe Quantum Dots Cytotoxicity: A Comparative Study on Microorganisms

Applicability of Quantum Dots in Biomedical Science

Physiological behavior of quantum dots

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