Physiological behavior of quantum dots

Xu, Ligeng; Chen, Chunying

doi:10.1002/wnan.1187

Cited by 5 publications

(4 citation statements)

References 87 publications

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“…In addition to reducing the amount of nanoparticles available for accumulation at a therapeutic site, opsonization, MPS sequestration and accumulation of nanoparticles in the tissues of the MPS can lead to inflammation and release of toxic byproducts by biodegradation, as well as uncontrolled and unpredictable localization . Modified biodistribution and undesired exposure of MPS tissues to radiolabeled nanomaterials or nanoparticles carrying chemotherapeutic agents for a prolonged time can cause hematopoietic, renal or bone marrow toxicity, and results in low therapeutic efficiency as well as poor sensitivity in PET and SPECT imaging …”

Section: The Issue Of Biomolecular Corona Formationmentioning

confidence: 99%

Zwitterionic‐Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

García

Zarschler

Barbaro

et al. 2014

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Nanoparticles represent highly promising platforms for the development of imaging and therapeutic agents, including those that can either be detected via more than one imaging technique (multi-modal imaging agents) or used for both diagnosis and therapy (theranostics). A major obstacle to their medical application and translation to the clinic, however, is the fact that many accumulate in the liver and spleen as a result of opsonization and scavenging by the mononuclear phagocyte system. This focused review summarizes recent efforts to develop zwitterionic-coatings to counter this issue and render nanoparticles more biocompatible. Such coatings have been found to greatly reduce the rate and/or extent of non-specific adsorption of proteins and lipids to the nanoparticle surface, thereby inhibiting production of the "biomolecular corona" that is proposed to be a universal feature of nanoparticles within a biological environment. Additionally, in vivo studies have demonstrated that larger-sized nanoparticles with a zwitterionic coating have extended circulatory lifetimes, while those with hydrodynamic diameters of ≤5 nm exhibit small-molecule-like pharmacokinetics, remaining sufficiently small to pass through the fenestrae and slit pores during glomerular filtration within the kidneys, and enabling efficient excretion via the urine. The larger particles represent ideal candidates for use as blood pool imaging agents, whilst the small ones provide a highly promising platform for the future development of theranostics with reduced side effect profiles and superior dose delivery and image contrast capabilities.

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Section: The Issue Of Biomolecular Corona Formationmentioning

confidence: 99%

Zwitterionic‐Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

García

Zarschler

Barbaro

et al. 2014

Small

445

371

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“…During the past ten years, several review articles have focused on the properties [ 2 , 13 , 14 , 15 ], applications [ 2 , 3 , 4 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ], toxicity [ 6 , 15 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ], synthesis [ 14 , 16 , 17 , 18 , 22 , 29 , 36 ], characterisation [ 16 , 17 , 37 , 38 , 39 , 40 ] and functionalisation [ 29 , 32 , 41 , 42 , …”

Section: Introductionmentioning

confidence: 99%

Semiconductor Quantum Dots as Target Analytes: Properties, Surface Chemistry and Detection

et al. 2022

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Since the discovery of Quantum Dots (QDs) by Alexey I. Ekimov in 1981, the interest of researchers in that particular type of nanomaterials (NMs) with unique optical and electrical properties has been increasing year by year. Thus, since 2009, the number of scientific articles published on this topic has not been less than a thousand a year. The increasing use of QDs due to their biomedical, pharmaceutical, biological, photovoltaics or computing applications, as well as many other high-tech uses such as for displays and solid-state lighting (SSL), has given rise to a considerable number of studies about its potential toxicity. However, there are a really low number of reported studies on the detection and quantification of QDs, and these include ICP–MS and electrochemical analysis, which are the most common quantification techniques employed for this purpose. The knowledge of chemical phenomena occurring on the surface of QDs is crucial for understanding the interactions of QDs with species dissolved in the dispersion medium, while it paves the way for a widespread use of chemosensors to facilitate its detection. Keeping in mind both human health and environmental risks of QDs as well as the scarcity of analytical techniques and methodological approaches for their detection, the adaptation of existing techniques and methods used with other NMs appears necessary. In order to provide a multidisciplinary perspective on QD detection, this review focused on three interrelated key aspects of QDs: properties, surface chemistry and detection.

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“…Reprinted from ref[94],Copyright (2007), American Chemical Society.While several types of ligands have been developed for enhancing the stability and yield of QDs in aqueous suspension the problem of aggregation and long term stability persists especially when QDs are dialyzed against buffers or water for purification following attachment of biofunctional molecules. Further advancement in the field using phosphine, peptides and cross linked dendrons have been made but these processes adds complexity to the ligand exchange process and increase the size of the QDs thereby compromising the two most unique advantages of the ligand exchange process[95].3.2 Surface silanization:The process of creating a layer of amorphous silica on the surface of nanoparticles is called silanization. The electrochemical properties of silica make it a suitable material for increasing the solubility of QDs in aqueous media while retaining most of its emission properties.…”

mentioning

confidence: 99%

“…Most developments have been made in the surface activation step of QDs for silanization. Earlier Correa-Duarte et al[95,97] exchanged the citrate coated QDs with silica coating by using(3-sulfanylprosulfanylpropyl) trimethoxysilane (MPS) as the first layer of silica followed by solvent exchange in ethanol. The silica shell was then grown in thickness using the conventional Stober process by addition of tetraethyl orthosilicate (TEOS) to the colloidal solution.…”

mentioning

confidence: 99%