Impact of human metapneumovirus infection on in and outpatients for the years 2006-2008 in Southern Brazil

Debur, Maria C.; Vidal, Luíne Rosele Renaud; Stroparo, Elenice; Nogueira, Meri Bordignon; Almeida, Sérgio Monteiro de; Takahashi, Gislene A.; Rotta, Indianara; Pereira, Luciane Aparecida; Silveira, Clyete Santos da; Delfraro, Adriana; Nakatani, Sueli M.; Skraba, Irene; Raboni, Sônia Mara

doi:10.1590/s0074-02762010000800010

Cited by 14 publications

(12 citation statements)

References 48 publications

(69 reference statements)

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“…Previously reported deaths in children associated with HMPV included children with risk factors and have occasionally had documented secondary bacterial infections. [7, 20, 21, 26, 28–30] There has also been a previously reported death due to encephalitis that possibly was associated with HMPV infection. [31, 32] To our knowledge, our case represents the first otherwise healthy child whose death was presumed to be respiratory failure associated with HMPV infection, though causality cannot be proven as no autopsy was performed.…”

Section: Discussionmentioning

confidence: 99%

Human metapneumovirus infections are associated with severe morbidity in hospitalized children of all ages

et al. 2013

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SUMMARY The impact of human metapneumovirus (HMPV) in children older than 5 years of age and the risk factors associated with disease severity for all ages have not been well characterized. A retrospective cohort study of 238 children 0–15 years hospitalized over a 3-year period was performed. Medical records were reviewed for demographic, clinical parameters and outcomes. Multivariable analyses were performed to identify independent factors associated with worse disease severity assessed by length of hospitalization (LOS), need for ICU care, respiratory support, and a disease severity score. Pulmonary diseases were associated with all outcomes of care, while congenital heart disease (CHD) and neuromuscular disorders were associated with longer LOS, and CHD and trisomy 21 were associated with worse severity scores independent of other covariables. Fever, retractions, use of steroids and albuterol were also associated with enhanced disease severity. Understanding the determinants of HMPV disease in children may help design targeted preventive strategies.

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Section: Discussionmentioning

confidence: 99%

Human metapneumovirus infections are associated with severe morbidity in hospitalized children of all ages

et al. 2013

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“…In Brazil, epidemiological studies have demonstrated the importance of viruses as etiological agents of respiratory disease 5,7,8,10,14,16,17,19,25,29,33,35,38,40,43,51,53,59,60 . However, because such studies are mostly focused on the most common respiratory pathogens (FLUAV, HRSV, HPIV, HRV and HAdV), the role of emerging viruses as etiological agents of respiratory disease among Brazilian children remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence was higher in outpatients (5.9%; n = 493), whose mean age was 19.7 years (range six months-75 years old), than in inpatients (3%; n = 1079), whose mean age was 7.6 months (range one month-26 years old). The outpatients had upper respiratory tract infections with flu-like symptoms and all hospitalized children had lower respiratory tract infections 19 . Other studies have shown a significant positivity for HMPV in Brazil as well 7,8,16,20,38,40,51,59,60 .…”

Section: Discussionmentioning

confidence: 99%

Acute respiratory viral infections in children in Rio de Janeiro and Teresópolis, Brazil

Albuquerque

Varella

Santos³

2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe frequency of viral pathogens causing respiratory infections in children in the cities of Rio de Janeiro and Teresópolis was investigated. Nasal swabs from children with acute respiratory illnesses were collected between March 2006 and October 2007. Specimens were tested for viral detection by conventional (RT)-PCR and/or real time PCR. Of the 205 nasal swabs tested, 64 (31.2%) were positive for at least one of the viral pathogens. Single infections were detected in 56 samples, 50 of those were caused by RNA viruses: 33 samples tested positive for rhinovirus, five for influenza A, five for metapneumovirus, four for coronavirus and, three for respiratory syncytial virus. For the DNA viruses, five samples were positive for bocavirus and one for adenovirus. Co-infections with these viruses were detected in eight samples. Our data demonstrate a high frequency of viral respiratory infections, emphasizing the need for a more accurate diagnosis particularly for the emerging respiratory viruses. The fact that the emerging respiratory viruses were present in 9.2% of the tested samples suggests that these viruses could be important respiratory pathogens in the country.

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“…10,14,15,35,42,43 Prevalent worldwide, hMPV is an important respiratory pathogen that manifests in young children less than 5 years of age. 4,11,25,32,34,38,39 Clinical symptoms caused by hMPV infection are similar to respiratory syncytial virus and include fever, cough, wheezing, dyspnea, rhinorrhea, sputum production, and asthma. 6,12,32 Rates of hMPV infection range from 5.5% to 25% among children hospitalized with respiratory illness.…”

Section: Human Metapneumovirus; Epidemiology; Reverse Transcription Pmentioning

confidence: 99%

Prevalence of human metapneumovirus in adults with acute respiratory tract infection in Beijing, China

Wang

Xiao

et al. 2012

Journal of Infection

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Impact of human metapneumovirus infection on in and outpatients for the years 2006-2008 in Southern Brazil

Abstract: The human metapneumovirus (hMPV), member of the Paramyxoviridae family, has been reported as an important agent involved with acute respiratory infections (ARIs

Cited by 14 publications

References 48 publications

Human metapneumovirus infections are associated with severe morbidity in hospitalized children of all ages

Human metapneumovirus infections are associated with severe morbidity in hospitalized children of all ages

Acute respiratory viral infections in children in Rio de Janeiro and Teresópolis, Brazil

Prevalence of human metapneumovirus in adults with acute respiratory tract infection in Beijing, China

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