HIV/AIDS-associated visceral leishmaniasis in patients from an endemic area in Central-west Brazil

Alexandrino-de-Oliveira, Priscilla; Santos-Oliveira, Joanna Reis; Dorval, Maria Elizabeth Cavalheiros; Da-Costa, Francisco das Chagas Brandão; Pereira, Gracy Regina Oliveira Leite; Cunha, Rivaldo Venâncio da; Paniago, Anamaria Mello Miranda; Da‐Cruz, Alda Maria

doi:10.1590/s0074-02762010000500016

Cited by 39 publications

(52 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The recurrence rate of VL in this study was significantly higher in the group of HIV/AIDS co-infected patients; it was higher than that reported by Marques et al 34 (26%) but lower than that reported by Oliveira et al 32 (56.5%). There was no significant association between the recurrence rates and the medications used including, amphotericin B deoxycholate, liposomal amphotericin B, lipid complex, and glucantime, as confirmed by the literature which has described similar efficacy between medications, although liposomal amphotericin B is associated with minor toxicities 9,18 .…”

contrasting

confidence: 77%

“…27 and Hurissa et al 28 . Our mortality rates were lower than those reported in a study conducted in Belo Horizonte (15) (17%) but higher than those reported by Oliveira et al 32 (8.7%) and Soares et al 35 (7.5%). The mortality and recurrence rates reflect the importance of the early detection and treatment of HIV in patients with VL, in order initiate appropriate treatment and prevent mortality.…”

contrasting

confidence: 75%

“…The median CD4 count of patients enrolled in this study was of 46 cells/mm 3 , a figure which is similar to that reported by Oliveira et al 32 (44.5 cells/mm 3 ) but different from that reported by Pintado et al 27 (90 cells/mm 3 ). Additionally, we found that the viral load was elevated in 92.5% (35/38) of patients, and that 76.3%, 72.0%, and 60.5% of patients had anemia, leukopenia, and thrombocytopenia, respectively.…”

supporting

confidence: 66%

See 2 more Smart Citations

Epidemiological profile of patients co-infected with visceral leishmaniasis and HIV/AIDS in Northeast, Brazil

Viana

Silva

Garcia

et al. 2017

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction: Visceral leishmaniasis (VL) and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/ AIDS) co-infection has been a research topic of interest worldwide. In Brazil, it has been observed that there is a relative underreporting and failure in the understanding and management of this important association. The aim of this study was to analyze epidemiological and clinical aspects of patients with VL with and without HIV/AIDS. Methods: We conducted an observational and analytical study of patients with VL followed in a Reference Service in the State of Maranhão, Brazil from 2007-2013. Results: In total 126 patients were enrolled, of which 61 (48.4%) were co-infected with HIV/AIDS. There were more males among those with HIV/AIDS (85.2%, P>0.05) or with VL only (81.5%, P>0.05). These findings significantly differed based on age group (P<0.003); the majority of patients were aged 31-40 years (41.0%) and 21-30 years (32.3%) among those with and without HIV/AIDS co-infection, respectively. The incidence of diarrhea and splenomegaly significantly differed between the two groups (P=0.0014 and P=0.019, respectively). The myelogram parasitic examination was used most frequently among those with HIV/AIDS (91.8%), followed by those with VL only (69.2%). VL recurrences and mortality were significantly higher in the HIV/AIDS co-infected patients (P<0.0001 and P=0.012, respectively). Conclusions: Patients with VL with or without HIV/AIDS co-infection were mostly adult men. Diarrhea was more frequent in HIV/AIDS co-infected patients, whereas splenomegaly was more common in patients with VL only. In the group of HIV/AIDS co-infected patients, there was a higher rate of VL recurrence and mortality.

show abstract

contrasting

confidence: 77%

contrasting

confidence: 75%

supporting

confidence: 66%

See 1 more Smart Citation

Epidemiological profile of patients co-infected with visceral leishmaniasis and HIV/AIDS in Northeast, Brazil

Viana

Silva

Garcia

et al. 2017

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…Evidence for a favorable response to therapy (clinical remission) was considered when the patient was afebrile and when physical signs as well as laboratory abnormalities significantly improved after a complete course of treatment 1 .…”

Section: Methodsmentioning

confidence: 99%

Diagnosing visceral leishmaniasis and HIV/AIDS co-infection: a case series study in Pernambuco, Brazil

Cavalcanti

Medeiros

Lopes

et al. 2012

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

HIV/AIDS-associated visceral leishmaniasis may display the characteristics of an aggressive disease or without specific symptoms at all, thus making diagnosis difficult. The present study describes the results of diagnostic tests applied to a series of suspected VL cases in HIV-infected/AIDS patients admitted in referral hospitals in Pernambuco, Brazil. From a total of 14 eligible patients with cytopenias and/or fever of an unknown etiology, and indication of bone marrow aspirate, 10 patients were selected for inclusion in the study. Diagnosis was confirmed by the following examinations: Leishmania detection in bone marrow aspirate, direct agglutination test, indirect immunofluorescence, rK39 dipstick test, polymerase chain reaction and latex agglutination test. Five out of the ten patients were diagnosed with co-infection. A positive direct agglutination test was recorded for all five co-infected patients, the Leishmania detection and latex agglutination tests were positive in four patients, the rK39 dipstick test in three, the indirect immunofluorescence in two and a positive polymerase chain reaction was recorded for one patient. This series of cases was the first to be conducted in Brazil using this set of tests in order to detect co-infection. However, no consensus has thus far been reached regarding the most appropriate examination for the screening and monitoring of this group of patients.

show abstract

“…Esta misma diversidad se refleja también en las dificultades que se presentan en su tratamiento, tanto en relación con el tipo de fármacos usados como en la dosificación de los mismos (Lindoso, Costa, Queiroz, & Goto, 2012). Su importancia médica es ampliamente conocida en las zonas tropicales del mundo, especialmente en su manifestación visceral, que ha causado y sigue ocasionando un número importante de muertes, especialmente cuando está asociada al virus del SIDA (Alexandrino-de-Oliveira et al, 2010). Los tipos de leishmaniosis cutáneos usualmente no causan la muerte, pero sus manifestaciones ulcerosas, no solo son estéticamente inconvenientes, sino dolorosas y proclives a infecciones secundarias bacterianas.…”

unclassified

Actividad contra Leishmania sp. (Kineplastida: Trypanosomatidae) de plantas en una Reserva Biológica de Costa Rica

Chinchilla-Carmona

Valerio-Campos

Sánchez-Porras

et al. 2014

RBT

View full text Add to dashboard Cite

Anti-leishmanial activity in plants from a Biological Reserve of Costa Rica. Leishmaniosis is an important human disease very difficult to treat. For this reason, many researchers in the world have been looking for anti-leishmanial chemical components present in several plant species. In Costa Rica, since no studies have been done in this field, this work aimed at the search of active chemical components in local plants that may have an activity against Leishmania sp. A total of 67 plants were selected from the Alberto Manuel Brenes Biological Reserve (REBAMB). For these collected plants, fresh or dried hidroalcoholic extracts of root, stem, mature or young leaves, flowers, and immature or mature fruits, were prepared under conventional methods. All extracts were tested for their effect against a strain of Leishmania (OCR with known characteristics). Firstly, by presumptive tests, we selected only those with some activity, and then, more specific studies were done to determine the IC 50 in µg/mL; a promising plant was considered only if at least one of its parts presented an IC 50 <100µg/mL. Under this parameter, the following active plants were obtained and their lowest and highest (23.4 and 97.5). Although the parasitic effect of fresh or dried extracts were almost similar, the fresh material slightly showed better results. That anti-parasitic effect occurred in one or more than four parts of the plant. Most of the active extracts did not produce lysis and aglutination which indicates a low toxicity. Since the species studied are different from those analyzed by other authors, we discuss the importance of these new findings, in relation to the new scientific knowledge, and the possible use of these plants as a leishmaniosis treatment. Rev. Biol. Trop. 62 (3): 1229-1240. Epub 2014 September 01.

show abstract

HIV/AIDS-associated visceral leishmaniasis in patients from an endemic area in Central-west Brazil

Abstract: An increase in morbidity associated with visceral leishmaniasis (VL) in human immunodeficiency virus (HIV)/ AIDS patients has been described in

Cited by 39 publications

References 26 publications

Epidemiological profile of patients co-infected with visceral leishmaniasis and HIV/AIDS in Northeast, Brazil

Epidemiological profile of patients co-infected with visceral leishmaniasis and HIV/AIDS in Northeast, Brazil

Diagnosing visceral leishmaniasis and HIV/AIDS co-infection: a case series study in Pernambuco, Brazil

Actividad contra Leishmania sp. (Kineplastida: Trypanosomatidae) de plantas en una Reserva Biológica de Costa Rica

Contact Info

Product

Resources

About