Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil

Filho, Alexandre Martins Portelinha; Nascimento, Charles Ulloffo do; Tannouri, Talita Nicastro; Troiani, Charlene; Ascêncio, Eloah Lopes; Bonfim, Renata Marques; D’Andrea, Lourdes Aparecida Zampieri; Prestes-Carneiro, Luiz Euribel

doi:10.1590/s0074-02762009000700003

Cited by 16 publications

(10 citation statements)

References 23 publications

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“…A systematic review of HIV–hepatitis co-infection in sub-Saharan Africa reported a prevalence of 15% for HBV and 7% for HCV [26]. In Brazil, a study on HIV, HCV and HBV co-infections reported a prevalence of 4·4% which is comparable to our study [21]. The majority of HIV/AIDS–hepatitis co-infected individuals in our study were male [23] and of Black [23] or Other race groups.…”

Section: Discussionsupporting

confidence: 85%

“…An HIV/AIDS individual was categorized as co-infected if he/she had been concurrently infected with confirmed hepatitis B or hepatitis C virus (acute and chronic) based on the CDC case definition [17–20] and residing in the state of Michigan during the period 2006–2009. The rationale for creating the co-infection variable was based on the fact that the three diseases share similar routes of transmission [21]. Any HIV/AIDS case which had a diagnosis of acute or chronic hepatitis B or C before 2006 was excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

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Hepatitis B and C co-infection in HIV/AIDS population in the state of Michigan

et al. 2013

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A retrospective cohort study was conducted from 1 January 2006 to 31 December 2009 in Michigan to estimate the prevalence of HIV and hepatitis co-infection and identify associated factors. The prevalence of co-infection was 4.1% [95% confidence interval (CI) 3.8-4.5]. Multivariable logistic regression analysis revealed a significant association between co-infection and being male and: of Black race [odds ratio (OR) 2.0, 95% CI 1.2-3.6] and of Other race (OR 3.5, 95% CI 1.7-7.0) compared to Hispanic race. A significant association was found between co-infection and risk categories of blood products (OR 11.1, 95% CI 6.2-20.2), injecting drug user (IDU) (OR 3.6, 95% CI 2.7-4.8) and men who have sex with men/IDU (OR 3.4, 95% CI 2.4-4.9) in addition to two interactions; one between sex and current HIV status and the other between current HIV status and age at HIV diagnosis. Our results document the changing epidemiology of HIV-hepatitis co-infection which can guide preventive measures and interventions to reduce the prevalence of hepatitis co-infection.

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Section: Discussionsupporting

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Hepatitis B and C co-infection in HIV/AIDS population in the state of Michigan

et al. 2013

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“…From 2010 to 2018, 751 patients with chronic HCV received a therapeutic regimen in the RH/AME complex; from 2015 to 2018, genotypes 1a and 1b were the most prevalent among the 197 patients investigated, a result previously found in patients infected with HCV who were followed in the RH from 2000 to 2006 [ 15 ]. Similar results were found in a survey representative of the whole country, which showed that genotype 1a was more prevalent in the south, southeast, and central regions, whereas genotype 1b was more prevalent in the northern regions [ 16 ].…”

Section: Discussionmentioning

confidence: 92%

Clinical, Epidemiological, and Geospatial Characteristics of Patients Infected with Hepatitis C Virus Treated with Second-Generation Direct-Action Antivirals in a Reference Center in a Mesoregion of São Paulo State, Brazil

et al. 2020

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Hepatitis virus infection is a major public health problem worldwide. Currently, Brazil has almost 700,000 cases. The Brazilian Unified Health System (SUS) provides therapeutic regimens for people infected with hepatitis C virus (HCV). We determined the clinical, laboratory, epidemiologic, and geospatial characteristics of patients infected with HCV treated with second-generation direct-action antivirals (DAAs) in a hospital reference center in São Paulo state, Brazil, using data from file records. A map was constructed using a geographic information system. From 2015 to 2018, 197 individuals received second-generation DAAs (mean age, 57.68 ± 1.36 years; interquartile range, 56.22–59.14 years; 58.9% male; 41.1% female). Genotypes 1a and 1b accounted for 75.7% of cases and the prevalent therapeutic regimen was sofosbuvir/simeprevir. Sustained viral response accounted for 98.9% and the METAVIR score F3/F4 for 50.8%. Increased alanine transferase was significantly correlated with an increase in α-fetoproteins (p = 0.01), and severe necro-inflammatory activity (p = 0.001). Associated comorbidities were found in 71.6%, mainly coronary artery and gastrointestinal disorders. The cumulative incidence in the region was 2.6 per 10,000 inhabitants. Our data highlight the role of reference hospitals in Brazil’s public health system in the treatment of HCV. Low incidence rates demonstrated the fragility of municipalities in the active search for patients.

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“…16 In the western region, all inmates diagnosed with HIV are treated and are followed by specialists in reference centres in Presidente Prudente. 17 18 Prevalence of 1.8% was detected in a prison in São Paulo state. 8 In a prospective study of 3362 inmates from 12 prisons in the central-west region of Brazil in 2013, a prevalence of 1.6% was found.…”

Section: Discussionmentioning

confidence: 95%

Prevalence and epidemiological characteristics of inmates diagnosed with infectious diseases living in a region with a high number of prisons in São Paulo state, Brazil

et al. 2020

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ObjectiveTo determine the prevalence and epidemiological characteristics of inmates diagnosed with infectious diseases living in a region with a high number of prisons, São Paulo, Brazil.DesignThis is a retrospective and descriptive study conducted from November 2017 to October 2018.SettingPrisons located in the western and northwestern regions of São Paulo, Brazil.MethodsWe conducted a retrospective analysis on infectious diseases and coinfections (HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and tuberculosis (TB)) of inmates from 28 prisons. Inmates were previously diagnosed following the protocol for control and surveillance of infectious diseases, through laboratory or imaging methods. A questionnaire was completed by the healthcare staff. Prevalence was obtained by dividing the number of individuals with positive results by the number of inmates in each prison. Locations of prisons were obtained and maps were constructed using geographic information systems.ResultsA total of 741 of 37 497 inmates (1.97%) were diagnosed with HIV, HBV, HCV, syphilis or TB. HIV was the most prevalent infectious disease (0.68%), followed by TB (0.66%), syphilis (0.2%), HCV (0.2%) and HBV (0.04%). For all of these diseases, prevalence rates varied from very low to high (3.11% and 2.45%) for TB and HIV, respectively, in the five prisons where they were most prevalent. HIV-syphilis was the most associated coinfection (OR, 63.7; 95% CI 41.4 to 96.7). Three of those diagnosed with the infection were female and the ratio of female to men was 0.004:1.ConclusionsOur findings demonstrate that the number of cases of infectious disease among inmates in the northwestern and western region of São Paulo is probably underestimated, with lower rates of HCV, HBV and syphilis. This represents a challenge to prisoners’ health. Improvements in diagnosis, mainly to reduce viral hepatitis, are crucial with benefits for inmates and the general population.

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Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil

Abstract: Few studies are available on hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection in populations living

Cited by 16 publications

References 23 publications

Hepatitis B and C co-infection in HIV/AIDS population in the state of Michigan

Hepatitis B and C co-infection in HIV/AIDS population in the state of Michigan

Clinical, Epidemiological, and Geospatial Characteristics of Patients Infected with Hepatitis C Virus Treated with Second-Generation Direct-Action Antivirals in a Reference Center in a Mesoregion of São Paulo State, Brazil

Prevalence and epidemiological characteristics of inmates diagnosed with infectious diseases living in a region with a high number of prisons in São Paulo state, Brazil

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