Larval recovery of Toxocara cati in experimentally infected Rattus norvegicus and analysis of the rat as potential reservoir for this ascarid

Santos, Sérgio Vieira dos; Lescano, Susana Angélica Zevallos; Castro, João Manoel de; Chieffi, Pedro Paulo

doi:10.1590/s0074-02762009000600020

Cited by 20 publications

(14 citation statements)

References 14 publications

(13 reference statements)

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“…2014), R. norvegicus are considered paratenic hosts for Toxocara sp., as after ingesting animal feces, mature eggs hatch and larvae migrate into rats’ tissues, where they do not mature (Lescano et al . 2004; Santos et al . 2009).…”

Section: Discussionmentioning

confidence: 99%

The helminth community of a population ofRattus norvegicusfrom an urban Brazilian slum and the threat of zoonotic diseases

et al. 2017

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Urban slums provide suitable conditions for infestation by rats, which harbour and shed a wide diversity of zoonotic pathogens including helminths. We aimed to identify risk factors associated with the probability and intensity of infection of helminths of the digestive tract in an urban slum population of Rattus norvegicus. Among 299 rats, eleven species/groups of helminths were identified, of which Strongyloides sp., Nippostrongylus brasiliensis and, the human pathogen, Angiostrongylus cantonensis were the most frequent (97, 41 and 39%, respectively). Sex interactions highlighted behavioural differences between males and females, as eg males were more likely to be infected with N. brasiliensis where rat signs were present, and males presented more intense infections of Strongyloides sp. Moreover, rats in poor body condition had higher intensities of N. brasiliensis. We describe a high global richness of parasites in R. norvegicus, including five species known to cause disease in humans. Among these, A. cantonensis was found in high prevalence and it was ubiquitous in the study area – knowledge which is of public health importance. A variety of environmental, demographic and body condition variables were associated with helminth species infection of rats, suggesting a comparable variety of risk factors for humans.

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Section: Discussionmentioning

confidence: 99%

The helminth community of a population ofRattus norvegicusfrom an urban Brazilian slum and the threat of zoonotic diseases

et al. 2017

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“…Relationship between muscle strength (Newtons) and body weight (g) (mean^SD) of female and male rats infected with T. cati or T. canis on days 5, 15 and 42 post infection; *significant differences with P , 0.05. (Lescano et al, 2004;Santos et al, 2009) in that T. cati larvae show a predilection for muscles compared with T. canis larvae.…”

Section: Discussionmentioning

confidence: 99%

Behavioural changes and muscle strength inRattus norvegicusexperimentally infected withToxocara catiandT. canis

Santos

Moura

Lescano³

et al. 2014

J. Helminthol.

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Toxocara canis and Toxocara cati are nematode parasites in dogs and cats, respectively, transmitted by ingestion of embryonated eggs, transmammary and transplacental (T. canis) routes and paratenic host predation. Many parasites use mechanisms that change the behaviour of their hosts to ensure continued transmission. Several researchers have demonstrated behavioural changes in mouse models as paratenic hosts for T. canis. However, there have been no studies on behavioural changes in laboratory rats (Rattus norvegicus) experimentally infected with T. cati. This study investigated behavioural changes and muscle strength in male and female rats experimentally infected with T. cati or T. canis in acute and chronic phases of infection. Regardless of sex, rats infected with T. cati showed a greater decrease in muscle strength 42 days post infection compared to rats infected with T. canis. However, behavioural changes were only observed in female rats infected with T. canis.

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“…SANTOS et al 92 performed the larval recovery of Toxocara cati in experimentally infected R. norvegicus and observed some differences in the migration of this ascarid compared with studies involving T. canis 65 : larval migration to the brain was less expressive in the case of T. cati and R. norvegicus does not appear to be a good model for ocular larva migrans compared with other rodent species 4 . However, this work reinforced the thesis that R. norvegicus is a potential reservoir for Toxocara spp.…”

Section: Research In Brazilmentioning

confidence: 99%

Human toxocariasis: contribution by Brazilian researchers

Chieffi

Santos

Queiroz

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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Larval recovery of Toxocara cati in experimentally infected Rattus norvegicus and analysis of the rat as potential reservoir for this ascarid

Cited by 20 publications

References 14 publications

The helminth community of a population ofRattus norvegicusfrom an urban Brazilian slum and the threat of zoonotic diseases

The helminth community of a population ofRattus norvegicusfrom an urban Brazilian slum and the threat of zoonotic diseases

Behavioural changes and muscle strength inRattus norvegicusexperimentally infected withToxocara catiandT. canis

Human toxocariasis: contribution by Brazilian researchers

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