Treatment for congenital toxoplasmosis: finding out what works

Utility of Immunoblotting for Early Diagnosis of Toxoplasmosis Seroconversion in Pregnant Women

“…Clinical manifestations of congenital toxoplasmosis at birth vary according to the stage of pregnancy at the time of infection from severe, if contamination occurs early during pregnancy, to asymptomatic in end-of-pregnancy contamination (2,4). It was recently shown that although early treatment of the primary infection during pregnancy has little or no impact on the fetomaternal transmission rate, it does reduce the incidence of sequelae in infected infants (7). In France, approximately 2,500 cases of primary Toxoplasma infection are observed in pregnant women every year, with around 400 to 600 cases of congenital toxoplasmosis.…”

Screening of Maternal Toxoplasmosis in Pregnancy: Laboratory Diagnostics from the Perspective of Public Health Requirements

“…Nonetheless, many limitations and biases of these studies have been discussed [8] and many toxoplasmosis experts propose important arguments in favor of the treatment concept [9,13,[17][18][19]. At present, further high quality studies are urgently needed to clarify the issue of treatment effectiveness [20].…”

Risk Factors, Pathogenesis and Diagnosis of Ocular Toxoplasmosis

“…The prophylaxis of congenitally acquired OT is based on national programs of prevention of CT (e.g. France, Austria) but their efficiency is discussed [80][81][82] and depends on the local epidemiology and virulence of strains [83]. Peyron et al [84] stated that "treating CT has little effect on the quality of life and visual function of the affected individuals".…”