Risk Factors, Pathogenesis and Diagnosis of Ocular Toxoplasmosis

Dupouy‐Camet, Jean; Talabani, Hana; Delair, Emmanuelle; Lesle, Florence; HeleneYera,; Brézin, Antoine P.

doi:10.5772/50267

Cited by 2 publications

(2 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanism underlying the occurrence of retinal damage in T. gondii infection is not fully understood, the immune response is thought to play a direct role in the pathogenesis of retinochoroiditis, and cytokines play a fundamental part. Th17 cells, essential mediators in inflammatory and autoimmune reactions in uveitis, are thought to play a significant role in the host's immune response to retinal tissue damage due to T. gondii infection [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to the researchers, these fndings indicated that the process of retinal tissue damage is not directly infuenced by IL-27 activity but involves various other infammatory mediators that may be initiated by T17 cell activation. Other factors, such as T. gondii strains and genetic polymorphisms, may infuence the host's immune response to T. gondii infection [31][32][33].…”

Section: Comparison Between Il-27 Levels In Ot and Seropositivementioning

confidence: 99%

See 1 more Smart Citation

The Decreased Treg Cells Number Associated with Retinal Lesion Size in Ocular Toxoplasmosis

Sofia,

Amalia,

Thomassawa

et al. 2024

Interdisciplinary Perspectives on Infectious Diseases

View full text Add to dashboard Cite

Introduction. The imbalance of the immune response is an important factor contributing to the incidence of ocular toxoplasmosis (OT). Regulatory T cells (Treg) play a key role in maintaining the balance between Th1 and Th17 immune responses, while interleukin-27 (IL-27) levels are related to the differentiation of Th17 cells. This study analyzes the differences in the number of Treg cells and the level of IL-27 between OT patients and seropositive individuals without ocular lesions and its correlation with retinal lesion size. Methods. This analytic observational study, conducted for 8 months, involved 11 OT patients and 10 seropositive individuals without ocular lesions. All subjects underwent a comprehensive ophthalmological examination. Retinal lesions were documented by fundus photographs and the size was measured using Digimizer 4.2.2.0 software. Isolation of peripheral blood mononuclear cells (PBMC) was performed to measure the number of Treg cells using flow cytometry and interleukin-27 levels were assessed using the Sandwich enzyme-linked immunosorbent assay (ELISA) technique. Data were analyzed with SPSS. Result. The number of Treg cells in the OT group (47.16 ± 15.66%) was lower than in the seropositive group without the ocular lesions (62.86 ± 17.08%) (p=0.029). The serum IL-27 levels in the OT group were not significantly different from the seropositive group without the ocular lesions (p=0.360). The number of Treg cells was significantly related to retinal lesion size (p=0.043), with a correlation coefficient of −0.648, indicating a strong and inverse correlation. There was no significant correlation between serum IL-27 levels and retinal lesion size (p=0.556). Conclusion. Ocular toxoplasmosis patients have a low number of Treg cells that are inversely related to the retinal lesion size. The size of the retinal lesion increases as the number of Treg cells decreases.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Comparison Between Il-27 Levels In Ot and Seropositivementioning

confidence: 99%