Cytokine profile associated with chronic and acute human schistosomiasis mansoni

Morais, Clarice Neuenschwander Lins de; Souza, Joelma Rodrigues de; Melo, Wlademir; Aroucha, Marcílio L; Miranda, Paulo Henrique Oliveira de; Domingues, Ana Lúcia Coutinho; Abath, Frederico G. C.; Montenegro, Sílvia Maria Lucena

doi:10.1590/s0074-02762008000600009

Cited by 35 publications

(29 citation statements)

References 30 publications

(41 reference statements)

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“…De Morais performed one research which showed that after SWAP stimulation, chronic patients, particularly hepatointestinals, produced higher levels of IL-4 in comparison with acute patients, suggesting the presence of a type 2 cytokine profile in these patients. Following SEA and SWAP stimulation, HS patients showed increased levels of IFN-gamma when compared with acute patients, indicating that HS disease in humans was also associated with a type 1 cytokine response (de Morais et al 2008). …”

Section: Discussionmentioning

confidence: 99%

Inflammatory cytokines IFN-γ, IL-4, IL-13 and TNF-α alterations in schistosomiasis: a meta-analysis

Sun

Yang

et al. 2011

Parasitol Res

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Cytokines play an important role in the immunological pathogenesis of schistosomiasis. Schistosomiasis would be associated with an imbalance in inflammatory cytokines that leads to a decrease of T helper (Th) 1 and an increase of Th2 cytokine secretion. Corresponding data so far have been inconsistent, so we performed a meta-analysis to assess whether cytokine alterations were risk factors for schistosomiasis progression. We searched MEDLINE, EMBASE, and CNKI databases for literatures including abstracts, reviews, and reference lists. Our studies included assessment of cytokine concentrations in vivo plasma or serum and secretion of cytokines in vitro by peripheral blood leukocytes from schistosomiasis patients or infected individuals with schistosome. The prototypic Th1 and Th2 cytokines IFN-γ and interleukin (IL)-4 were assessed as well as IL-13 and tumor necrosis factor-alpha (TNF-α). The results implied that an increase occurs in TNF-α and IL-4 with schistosomiasis progression.

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Section: Discussionmentioning

confidence: 99%

Inflammatory cytokines IFN-γ, IL-4, IL-13 and TNF-α alterations in schistosomiasis: a meta-analysis

Sun

Yang

et al. 2011

Parasitol Res

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“…Cellular immune responses, although involved in resistance, mediate most of schistosome-related pathology [203, 204], which can be divided into acute and chronic diseases based on disease progression. Acute schistosomiasis is a debilitating febrile disease which often occurs in individuals with no experience of infection.…”

Section: Immune Responses During Schistosome Infectionmentioning

confidence: 99%

Human Schistosome Infection and Allergic Sensitisation

Rujeni

Taylor

Mutapi

2012

Journal of Parasitology Research

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Several field studies have reported an inverse relationship between the prevalence of helminth infections and that of allergic sensitisation/atopy. Recent studies show that immune responses induced by helminth parasites are, to an extent, comparable to allergic sensitisation. However, helminth products induce regulatory responses capable of inhibiting not only antiparasite immune responses, but also allergic sensitisation. The relative effects of this immunomodulation on the development of protective schistosome-specific responses in humans has yet to be demonstrated at population level, and the clinical significance of immunomodulation of allergic disease is still controversial. Nonetheless, similarities in immune responses against helminths and allergens pose interesting mechanistic and evolutionary questions. This paper examines the epidemiology, biology and immunology of allergic sensitisation/atopy, and schistosome infection in human populations.

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“…High IFN-γ levels in controls have been reported before in response to AWA and SEA. 16 It is possible that components of these antigenic mixtures bear pathogen-associated molecular patterns and react with pattern recognition receptors on immune cells, such as monocytes, B-lymphocytes , or natural killer (NK) cells. The IFN-γ response to AWA in uninfected subjects might be produced by NK cells, which can readily release IFN-γ in response to stimulation by pathogen-associated molecular patterns (PAMPs).…”

Section: Discussionmentioning

confidence: 99%

“…It has been argued that it makes biological sense for IL-13, IL-5, and IFN-γ to have a central role in the response to infection with Schistosoma spp. 16,30 Because of IL-13's function in signaling B cells to switch to IgE production and IL5's and IL-13's principal role in recruiting and activating eosinophils, these cytokines are important in the initial response to invading cercaria and later on, to schistosomula. 30 Eosinophilia is known to be associated with Katayama syndrome, 17,19 and the stronger IL-5 and IL-13 responses that we found may reflect stronger activation of eosinophils at the time of infection in the travelers with Katayama syndrome.…”

Section: Discussionmentioning

confidence: 99%