Brazilian flora extracts as source of novel antileishmanial and antifungal compounds

Tempone, André G.; Sartorelli, Patrı́cia; Teixeira, Denise; Prado, Frederico Oliveira; Calixto, Ivete A R L; Lorenzi, Harri; Melhem, M. S. C.

doi:10.1590/s0074-02762008000500006

Cited by 62 publications

(55 citation statements)

References 29 publications

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“…Also the leave extract of A. chevalieri has been reported for effective anti-bacterial and anti-candida activity from Brazilian flora (Tempone et al, 2008) because of the presence of active compounds (alkaloids, aminoacids, saponins, flavones, Quinone's, tannins, carbohydrates) and this is also in agreement with the anti-bacterial activity exhibited by the plant extract of A. chevalieri in this study.…”

Section: Comparing the Efficacy Of The Root And Leaves Of K Africanasupporting

confidence: 90%

Untitled

2017

GJMA

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The investigation was carried out to determine the antimicrobial activity of the Leaf and Root extracts of Kigelia africana (nonon giwa) and Albizia chevalieri (katsari) against Staphylococcus aureus. Antimicrobial activity was evaluated by disc diffusion method and MIC and MBC were calculated by double fold dilution method. The antimicrobial activity result shows 20mm zone of inhibition Kigelia africana leaf at 100% concentration and 16mm zone of inhibition for albezia chevalieri leaf at same concentration while for the roots 14mm and 11mm zone of inhibition at 100% concentration. The maximum inhibition zone is found at 20mm and minimum inhibition zone at 11mm. Also the antimicrobial result shows the MIC of 6.25mg/ml against Staphylococcus aureus and MBC of 12.5mg/ml and 10.5mg/ml for both extracts. The study reveals that the extracts possess antimicrobial activity in a dose dependent manner. This antimicrobial activity may be due to the presence of some active compounds, further studies are highly needed for the drug development.

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Section: Comparing the Efficacy Of The Root And Leaves Of K Africanasupporting

confidence: 90%

Untitled

2017

GJMA

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“…Plants are usually used in traditional medicine as antimicrobial agents and their essential oils and extracts have been known to possess antibacterial and antifungal proprieties (Cowan, 1999;Tempone et al, 2008). Previous reports have suggested that several essential oils and extracts show important antifungal activity against yeasts, dermatophytes and Aspergillus isolates, and have therapeutic potential, mainly against fungal diseases involving mucosal, cutaneous and respiratory tract infections (Cavaleiro et al, 2006;Tempone et al, 2008;Tavares et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

In vitro antifungal activity and cytotoxic effect of essential oils and extracts of medicinal and aromatic plants against Candida krusei and Aspergillus fumigatus

Correa-Royero¹,

Tangarife²,

Durán³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Atividade antifúngica in vitro e os efeitos citotóxicos de óleos essenciais e extratos de plantas medicinais e aromáticas contra Candida krusei e Aspergillus fumigatus" As plantas são geralmente utilizadas na medicina tradicional como agentes antimicrobianos e seus óleos essenciais e extratos foram conhecidos por possuir atividade antifúngica. O objetivo deste estudo foi avaliar in vitro a atividade de 32 óleos essenciais e 29 extratos contra Candida krusei e Aspergillus fumigatus, bem como o efeito citotóxico em células Vero. A curva do tempo-morte e a interação entre antifúngicos e Chenopodium ambrosioidese do extrato de Myrcia cucullata mostraram atividade antifúngica contra C. krusei (geometric means of the minimal inhibitory concentration [GM-MIC] 7,82 e 31,25 µg/ mL, respectivamente). Lippia citriodora foi ativa contra C. krusei e A. fumigatus (GM-CIM = 99,21 µg/mL e 62,5 µg/mL, respectivamente). Os testes de tempo-morte feitos com óleo de C. ambrosioides mostraram atividade fungicida em 4x MIC. A interação do óleo C. ambrosioides com itraconazol e anfotericina B foi testada pela técnica de xadrez. Nenhuma interação foi detectada pela combinação do óleo C. ambrosioides com anfotericina B e itraconazol (intervalo fractional inhibitory index [FICI] = 1,03-1,06 e 1,03-1,00, respectivamente). Os ensaios de citotoxicidade para todas as amostras foram realizadas com MTT. Apenas os óleos Hedyosmun sp. e L. dulcis foram citotóxicos.Unitermos: Candida krusei, Aspergillus fumigatus, óleos essenciais, extratos, curva do tempomorte, técnica de xadrez. ABSTRACT:The plants are usually used in traditional medicine as antimicrobial agents and their essential oils and extracts have been known to possess antifungal activity. The aim of this study was to evaluate the activity of 32 essential oils and 29 extracts in vitro against C. krusei and A. fumigatus as well as the cytotoxic effect on Vero cells. Time-kill curve and interaction between antifungal and the most active sample against C. krusei, was also evaluated. The oils from C. ambrosioides and the extract of M. cucullata showed antifungal activity against C. krusei (GM-MIC 7.82 and 31.25 µg/mL, respectively). L. citriodora was active against C. krusei and A. fumigates (GM-MIC = 99.21 µg/mL and 62.5 µg/mL respectively). Time-kill assays done with C. ambrosioides oil showed fungicidal activity at 4x MIC. The interaction of C. ambrosioides oil with itraconazole and amphotericin B was tested following the chequerboard technique. No interaction was detected for the combination of C. ambrosioides oil with amphotericin B and itraconazole (FICI range = 1.03-1.06 and 1.03-1.00, respectively). Cytotoxicity assays for all samples were carried out with MTT. Only the oil from Hedyosmun sp. and L. dulcis were cytotoxic.

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“…The hydroalcoholic and methanol extracts obtained from the leaves of L. alba exerted effects against C. krusei, with MIC values of 125 and 165.2µg/mL, respectively 11,12 . The hydroalcoholic extract also showed activity against C. tropicalis, with a MIC of 1,000µg/mL 11 .…”

Section: Candida Krusei Candida Parapsilosis Candida Tropicalis Cryptmentioning

confidence: 99%

In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species

Oliveira

Ferreira

Rosa

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Introduction:There are few studies reporting the antifungal activities of Lippia alba extracts. Methods: A broth microdilution assay was used to evaluate the antifungal effects of Lippia alba extracts against seven yeast species of Candida and Cryptococcus. The butanol fraction was investigated by gas chromatography-mass spectrometry. Results: The butanol fraction showed the highest activity against Candida glabrata. The fraction also acted synergistically with itraconazole and fl uconazole against C. glabrata. The dominant compounds in the butanol fraction were 2,2,5-trimethyl-3,4-hexanedione, 3,5-dimethyl-4-octanone and hexadecane. Conclusions: The butanol fraction may be a good candidate in the search for new drugs from natural products with antifungal activity.

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Brazilian flora extracts as source of novel antileishmanial and antifungal compounds

Cited by 62 publications

References 29 publications

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In vitro antifungal activity and cytotoxic effect of essential oils and extracts of medicinal and aromatic plants against Candida krusei and Aspergillus fumigatus

In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species

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