Epidemiology of Chagas disease in non endemic countries: the role of international migration

Schmuñis, Gabriel A.

doi:10.1590/s0074-02762007005000093

Cited by 473 publications

(328 citation statements)

References 42 publications

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“…The rate of T. cruzi seropositivity prevalence in our cohort of heart disease patients is relatively high in comparison to that of some other population groups, such as blood donors and asymptomatic inhabitants in highly infested vector areas [3,8,9]. This fact should also call attention to the possibility of a higher T. cruzi infection rate in the Salvadoran population in the last decades than the rates published previously [3,8,9].…”

Section: Discussionmentioning

confidence: 49%

“…This fact should also call attention to the possibility of a higher T. cruzi infection rate in the Salvadoran population in the last decades than the rates published previously [3,8,9].…”

Section: Discussionmentioning

confidence: 87%

“…Since its identification in 1909, this disease had been confined to Latin America until it emerged in the United States and Europe in the last few decades due to the high immigration rate from endemic regions [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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ELISA seroprevalence of Trypanosoma cruzi in a cohort of heart disease patients

Rodriguez

Hernandez

Garcia

et al. 2013

J Infect Dev Ctries

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Introduction: Chagas disease is the most important parasitic disease in El Salvador and Latin America. The disease has two phases: acute and chronic, with an intermediate unspecified phase. The chronic phase develops in 30% of infected persons and its most common manifestation is cardiac disease. This study aimed to obtain reference data for the prevalence of T. cruzi seropositivity in a cohort of cardiac patients. Methodology: A cross-sectional study involving consecutive heart disease patients consulting at the National Hospital Rosales was conducted over a six-month period. Congenital heart disease patients were excluded. A survey, file review, and ELISA serological test were conducted for each subject. Results: Out of 455 subjects, 76 were seropositive for T. cruzi, giving a seropositivity prevalence of 16.7%. The average age of the patients was 58.09 years and the female:male ratio was 2.79:1. No significant difference was found between T. cruzi seropositive and seronegative patients in terms of age and gender. No association between T. cruzi serological status and either area of residence or seeing vectors in the house was found. However, living in the Salvadoran western region during childhood was significantly associated with seropositivity (p = 0.003). Other factors associated with T. cruzi seropositivity included: clinical diagnosis of cardiac Chagas disease; electrocardiographic (ECG) findings of a permanent pacemaker, all atrioventricular (AV) blocks and right bundle branch block; and grade III-IV radiological cardiomegaly. Conclusions: T. cruzi seropositivity prevalence was found to be 16.7% among heart disease patients in a public reference hospital.

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Section: Discussionmentioning

confidence: 49%

“…This fact should also call attention to the possibility of a higher T. cruzi infection rate in the Salvadoran population in the last decades than the rates published previously [3,8,9].…”

Section: Discussionmentioning

confidence: 87%

See 1 more Smart Citation

ELISA seroprevalence of Trypanosoma cruzi in a cohort of heart disease patients

Rodriguez

Hernandez

Garcia

et al. 2013

J Infect Dev Ctries

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“…In view of the low sensitivity of parasitological tests, diagnosis during the chronic phase is at present essentially serological. Accurate diagnosis at this stage is important for the individual and also for epidemiological reasons, because transmission by way of blood transfusion and organ transplantation occurs in endemic and non-endemic countries (Schmunis 1991(Schmunis , 2007. Recently, Souza et al (2008) described a case of acute Chagas disease with severe cardiac involvement following an orthotopic liver transplant from a cadaver donor.…”

Section: What Methods Are Currently Available For Diagnosis During Thmentioning

confidence: 99%

Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies?

Gomes

Lorena

Luquetti

2009

Mem. Inst. Oswaldo Cruz

118

107

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“…A new epidemiological, economic, social and political problem has been created with the internationalization of Chagas disease due to legal and illegal migration from the endemic countries of Latin America to nonendemic countries in North America, Europe, Asia and Oceania, in particular the United States, Canada, Spain, France, Switzerland, Japan, emerging Asian countries and Australia (Schmunis 2007). These migrations have created new epidemiological and public health problems for the countries that have received the infected migrants.…”

Section: Epidemiology Of Chagas Diseasementioning

confidence: 99%