Detection and molecular characterization of group A rotavirus from hospitalized children in Rio de Janeiro, Brazil, 2004

Carvalho-Costa, Filipe Aníbal; Assis, Rosane Maria Santos de; Fialho, Alexandre Madi; Bóia, Márcio Neves; Alves, Daniele Pires Dias; Martins, Carolina Maria Miranda de Assis; Leite, José Paulo Gagliardi

doi:10.1590/s0074-02762006000300012

Cited by 28 publications

(25 citation statements)

References 26 publications

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“…In Brazil, several studies have reported frequencies of rotavirus infection between 20-70%, especially in younger children (Santos et al 2002, Luz et al 2005, Carvalho-Costa et al 2006. Our results are comparable to those from large cities of different states which showed the occurrence of rotavirus at a rate of approximately 23% among infants hospitalized for acute diar- Number of positive (Frequency %) Number of positive (Frequency %) rhea.…”

Section: Discussionsupporting

confidence: 79%

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Rotavirus and adenovirus in Rondônia

Magalhães

Nogueira

Grava

et al. 2007

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 79%

“…In Brazil, frequencies of rotavirus infection between 20-70% have been reported especially in younger children (Santos et al 2002, Luz et al 2005, Carvalho-Costa et al 2006.…”

mentioning

confidence: 99%

Rotavirus and adenovirus in Rondônia

Magalhães

Nogueira

Grava

et al. 2007

Mem. Inst. Oswaldo Cruz

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“…[n = 6 (10.5%)]. The results are consistent with a previous study performed in samples from hospitalised children in RJ (Carvalho-Costa et al 2006, 2011, Leite et al 2008. Previously, the G1 genotype was the most common genotype found worldwide and this genotype is the component of the attenuated monovalent RVA vaccine (Rotarix ® ) that was licensed for routine infant immunisation in Brazil in 2006 (Leite et al 2008).…”

supporting

confidence: 87%

“…Due to the short evaluation period of this study, the seasonality of the viruses could not be inferred; however, the timing of the RVA and NoV infections (p = 0.0149) confirmed previous findings demonstrating increased positivity during the driest months (June-August) of the year in Southwest Brazil (Bittencourt et al 2000, Araújo et al 2002, Carvalho-Costa et al 2006.…”

supporting

confidence: 83%

“…More than 50% of the AGE cases investigated in this study were in children aged up to six months, reflecting the well-established trend that this viral infection is more severe in very young children (Barnes et al 1998, Carvalho-Costa et al 2006). In addition, NoV was detected in 55.5% (10/18) of the children aged more than one year and in 22.9% (14/61) of the children under one year of age and this difference was statistically significant (p = 0.0187).…”

supporting

confidence: 63%

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Genotyping of gastroenteric viruses in hospitalised children: first report of norovirus GII.21 in Brazil

Ferreira

Garcia

Xavier

et al. 2012

Mem. Inst. Oswaldo Cruz

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This retrospective study (April-September 2003) was designed to investigate the roles of the main viruses responsible for cases of acute infantile gastroenteritis in hospitalised children up to two years of age. The viruses were identified in 64.7% (88/136) of the cases and the detection rates of rotavirus A (RVA), norovirus (NoV) and astrovirus were 41.9% (57/136), 30.3% (24/79) and 12.7% (7/55), respectively. RVA and NoV were detected in 20 of the 24 reported nosocomial infection cases. This study identified the first circulation of the genotype NoV GII.21 in Brazil and highlights the need to establish differential diagnoses through active laboratorial surveillance

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Genotypes and molecular epidemiology of human astroviruses in hospitalized children with acute gastroenteritis in Rio de Janeiro, Brazil

Victoria

Carvalho-Costa

Heinemann

et al. 2007

Journal of Medical Virology

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Human astrovirus (HAstV) is an important pathogen that causes acute gastroenteritis mainly in children up to 5 years old worldwide. A total of 318 fecal samples were collected from January to December of 2004 from children with acute gastroenteritis hospitalized in Rio de Janeiro (RJ), Brazil. The samples were obtained from three public hospitals and were previously investigated for the presence of rotavirus (RV) and enteric adenovirus (AdV). The aim of this study was to determine the prevalence and molecular characterization of HAstV by reverse-transcription polymerase chain reaction (RT-PCR) and partial sequencing of open reading frame 2 (ORF2). HAstV infections were detected in 43 (14%) of the samples, of which 19 (6%) were mixed infections with HAstV and RV. HAstV were identified in all age groups, with 85% of the cases occurring in children younger than 2 years old. HAstV infections were more prevalent from March to May. Diarrhea, vomiting, and fever were the main clinical manifestations observed in these infections. Partial capsid sequencing of 35 HAstV strains characterized 25 (71%) as genotype 1 (HAstV-1), 6 (17%) HAstV-2, 3 (9%) HAstV-8, and 1 (3%) HAstV-4. Based on the genetic variability, three lineages were observed between RJ HAstV-1 strains. This study demonstrated the importance of HAstV infections causing acute infantile gastroenteritis in hospitalized children in RJ, Brazil. Molecular epidemiological surveillance is helpful for designing prevention strategies of HAstV transmission.

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Detection and molecular characterization of group A rotavirus from hospitalized children in Rio de Janeiro, Brazil, 2004

Abstract: Rotavirus is a major cause of infantile acute diarrhea

Cited by 28 publications

References 26 publications

Rotavirus and adenovirus in Rondônia

Rotavirus and adenovirus in Rondônia

Genotyping of gastroenteric viruses in hospitalised children: first report of norovirus GII.21 in Brazil

Genotypes and molecular epidemiology of human astroviruses in hospitalized children with acute gastroenteritis in Rio de Janeiro, Brazil

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