Ticks, ivermectin, and experimental Chagas disease

Dias, João Carlos Pinto; Schofield, Christopher J.; Machado, Evandro Marques de Menezes; Fernandes, Alexandre

doi:10.1590/s0074-02762005000800002

Cited by 28 publications

(20 citation statements)

References 13 publications

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“…In contrast, fipronil either impregnated in collars or applied as a spray or pour-on formulation on dogs exerted limited effects on the bugs (Gürtler et al, 2009b;Amelotti et al, 2012). Subcutaneous injection of dogs with ivermectin produced increased mortality of T. infestans and R. neglectus nymphs relative to control dogs until 7 days post-treatment (Dias et al, 2005). Enhanced prevention of dog infections with T. cruzi may be achieved through targeted residual insecticide spraying of kennels or other dog resting sites, and use of insecticide-impregnated collars with repellent effects.…”

Section: Control Methodsmentioning

confidence: 94%

Reservoir host competence and the role of domestic and commensal hosts in the transmission of Trypanosoma cruzi

2015

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Section: Control Methodsmentioning

confidence: 94%

Reservoir host competence and the role of domestic and commensal hosts in the transmission of Trypanosoma cruzi

2015

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“…(Frederico, 2016). However their effectiveness to control ticks is not well established, because most of available studies the dogs are naturally infested (Dias et al, 2005;Morsy and Haridy, 2000;Roy and Roy, 2010).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of pharmacokinetics and efficacy of ivermectin following oral administration in dogs against experimental infection of Ctenocephalides felis felis and Rhipicephalus sanguineus

Magalhães

Cid

Ferreira

et al. 2016

Veterinary Parasitology

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With the increasing number of pets in home the human-animal relationship is increasingly close and care about control disease growing. Ivermectin (IVM) is frequently used because its proven safety. IVM is recommended for the treatment of demodectic scabies and prevention of heartworm in dogs, but informally is extremely used to control of Ctenocephalides felis felis and Rhipicephalus sanguineus. The aim of this study is evaluate the use of IVM in dogs, by the oral route at 0.6μg/kg dose, against experimental infection of these parasites using the construction of the plasma concentration curve and efficacy study. A IVM quantification method in canine plasma using HPLC-FL was developed and validated based on RE n°899/03 ANVISA. The samples collected during the efficacy test was analyzed by this validated method and prove C of 350ng/mL at 4h (t) and AUC of 8411ng/h/mL. Spite of formulation have shown good absorption, the highest efficiency values found for Rhipcephalus sanguineus and Ctenocephalides felis felis were very low, 35% and 67% respectively, demonstrating this not be the most appropriate treatment for the control of these parasites.

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“…Among these, T. rubrofasciata is known to be a T. cruzi carrier in Latin America. However, as previously summarized [14] , various species of flea, fly, bedbug, mosquito and lice have been suggested as possible candidates for T. cruzi transmission. Ticks ( Ixodida ), were seen as another potential vector for T. cruzi in Europe, as some tick subspecies can carry T. cruzi , but it has not yet been demonstrated that ticks are able to transfer T. cruzi to humans.…”

Section: Basics Of Chagas Disease Etiology and Epidemiologymentioning

confidence: 96%

Chronic Chagas disease: from basics to laboratory medicine

Haberland

Saravia

Wallukat

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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Chagas disease, caused by Trypanosoma cruzi infection, is ranked as the most serious parasitic disease in Latin America and has huge potential to become a worldwide problem, due to increasing migration, and international tourism, as well as infectant transfer by blood contact and transfusion, intrauterine transfer, and organ transplantation. Nearly 30% of chronically-infected patients become symptomatic, often with a latency of 10–30 years, developing life-threatening complications. Of those, nearly 90% develop Chagas heart disease, while the others manifest gastrointestinal disease and neuronal disorders. Besides interrupting the infection cycle and chemotherapeutic infectant elimination, starting therapy early in symptomatic patients is important for counteracting the disease. This would be essentially supported by optimized patient management, involving risk assessment, early diagnosis and monitoring of the disease and its treatment. From economic and logistic viewpoints, the tools of laboratory medicine should be especially able to guarantee this. After summarizing the basics of chronic Chagas disease, such as the epidemiological data, the pathogenetic mechanisms thought to drive symptomatic Chagas disease and also treatment options, we present tools of laboratory medicine that address patient diagnosis, risk assessment for becoming symptomatic and guidance, focusing on autoantibody estimation for risk assessment and heart marker measurement for patient guidance. In addition, increases in levels of inflammation and oxidative stress markers in chronic Chagas disease are discussed.

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Ticks, ivermectin, and experimental Chagas disease

Abstract: Following an infestation of dogticks in kennels housing

Cited by 28 publications

References 13 publications

Reservoir host competence and the role of domestic and commensal hosts in the transmission of Trypanosoma cruzi

Reservoir host competence and the role of domestic and commensal hosts in the transmission of Trypanosoma cruzi

Evaluation of pharmacokinetics and efficacy of ivermectin following oral administration in dogs against experimental infection of Ctenocephalides felis felis and Rhipicephalus sanguineus

Chronic Chagas disease: from basics to laboratory medicine

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