The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review

Basso, Luiz Augusto; Silva, Luiz Hildebrando Pereira da; Fett-Neto, Arthur Germano; Azevedo, Walter Filgueira de; Moreira, Ícaro de Souza; Palma, Mário Sérgio; Calixto, João Β.; Filho, Spartaco Astolfi; Santos, Ricardo Ribeiro dos; Soares, Milena Botelho Pereira; Santos, Daniel Silas Veras dos

doi:10.1590/s0074-02762005000600001

Cited by 85 publications

(68 citation statements)

References 234 publications

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“…The large biological and chemical diversity mainly within the territory of tropical forests can lead to discovery, development and exploration of new metabolites for therapeutic value. Strategies to search for natural compounds based on ethno-botanical and chemo-taxonomical studies were described (Basso et al 2005). The present work followed also the previous study on inhibition activities of limited number of phenolic compounds toward serine proteases (Jedinák et al 2006).…”

Section: Resultsmentioning

confidence: 99%

Proteinase inhibition and antioxidant activity of selected forage crops

et al. 2010

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The hypothesis of the possible therapeutic potential of selected species of forage crops is discussed. Extracts from genotypes of Anthyllis sp., Astragalus sp., Coronilla sp., Lotus sp., Medicago sp., Melilotus sp., Onobrychis sp. and Trifolium sp. were prepared and tested for proteinase inhibition and antioxidant activities. We found that Trifolium pratense accession POLKIE99-3 expressed the highest relative trypsin inhibition activity (80.0%) compared to standards. The highest thrombin inhibition activity (81.4%) was detected in the Medicago sativa old cultivar Hodonínka, whereas the highest relative urokinase inhibition activity (62.5%) was expressed by the local population Nitranka. Relatively high antioxidant properties of Trifolium sp. accessions, Trifolium pratense genetic resources SVKZAH98-40, were of interest. Results of this study confirmed that there are significant differences in proteinase inhibition and antioxidant activity among important selected agricultural crops. The present paper may also be the starting point of the research aimed for development of new functional food and nutraceuticals, and/or of the research focused on new secondary metabolites with potential as bioactive compounds.Key words: trypsin; thrombin; urokinase; inhibition; antioxidant; activity; forage crops.Abbreviations: AOX, antioxidant activity; BBI, Bowman-Birk inhibitor; DMSO, dimethyl sulphoxide; Rel%BT, relative percentage value of activity to standardized black tea extract; Rel%Q, relative percentage value of activity to standard quercetin; SHE, sunflower oil hydrolysate ethanol; SITh, selectivity index of thrombin; SIU, selectivity index of urokinase; ThIA, thrombin inhibition activity; TrIA, trypsin inhibition activities; UIA, urokinase inhibition activity.

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Section: Resultsmentioning

confidence: 99%

Proteinase inhibition and antioxidant activity of selected forage crops

et al. 2010

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“…Therefore ongoing research tries to identify new molecules that either treat or provide benefit for individuals with such illnesses. Plants are an important source of these molecules and about 50% of drugs introduced into the market during the last 20 years have been derived directly or indirectly from small biogenic molecules (Vuorela et al, 2004;Basso et al, 2005). The anti-inflammatory, anti-allergic and immunomodulatory properties of plant extracts have been widely shown in several studies (Kim et al, 2004;Jeon et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…And nowadays following the traditional use of plants, some pharmacological screenings have led to new drugs discovery. Indeed, plants have been the leads of about 25% of drugs introduced into the market during the last 20 years (Vuorela et al, 2004;Basso et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Ethnobotanical Study of Plants Used to Treat Asthma in the Maritime Region in Togo

Gbekley

Katawa

Karou

et al. 2016

AJTCAM

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Background: Asthma is one of the most common chronic diseases in modern society and it is evident that its incidence and severity are increasing, however very little is known about the plants used in the management of the disease. This study therefore aimed to document the plants usage in the Togolese traditional medicine to treat asthma. Methodology: From January to June 2015, an ethnobotanical survey was conducted using a semi-structured questionnaire with traditional healers (THs) in the southern region of Togo. The importance of the plants species was assessed by the calculated use values. Results: In Total, 121 THs (92 males and 29 females) were interviewed and 98 plants species belonging to 54 families were identified as curing asthma. The most represented families were: Leguminosae with 7 species followed by Euphorbiaceae and Rutaceae contributing with 6 and 5 species respectively. Based on the calculated use values the most important species were Carcica papaya L., Cataranthus roseus L., Eucalyptus camaldulensis Dehnh., Piper guineense Thonn., Eucalyptus citriodora Hook., Eucalyptus globules Labill. and Euphorbia hirta L. The leaves and the root were the parts predominantly used to prepare the formulations, mainly decoctions, administrated by oral route. Clinical manifestations such as wheezing (91.74%), difficulty as speaking or coughing (73.55%), dyspnea (66.94%), dry cough (52.89%), sweating and increased heart rate (52.07%) were used by TH to diagnose the disease. Conclusion: This study showed initial evidence of the use of plant materials by Togolese TH to heal asthma. These results could be a starting point for laboratory screenings.

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“…The plant chemical diversity is also driven by these forces, in an attempt to best adapt the plant to suit the particular abiotic stresses, fauna, and microbes that coexist in the environment. Certain areas of vegetation, such as the Amazonian Forest, Atlantic Forest, Cerrado (Brazilian Savanna), and Caatinga, are rich in biodiversity and are therefore of great interest for the discovery of natural compounds with biological activity against diseases (Basso et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical properties of 'sucupira' (Pterodon spp.)

Hansen

Haraguchi

Alonso

2010

Braz. J. Pharm. Sci.

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The plant of the genus Pterodon (Fabaceae, Leguminosae), commonly known as 'sucupira' or 'faveira', are disseminated throughout the central region of Brazil and has frequently been used in popular medicine for its anti-rheumatic, analgesic, and anti-inflammatory properties. In recent years, interest in these plants has increased considerably. The biological effects of different phytoextracts and pure metabolites have been investigated in several experimental models in vivo and in vitro. The literature describes flavonoids, triterpene and steroids, while one paper presented studies with proteins isolated from the genus. This review provides an overview of phytochemical and pharmacological research in Pterodon, showing the main chemical compounds studied to date, and focusing on the relationship between these molecules and their biological activity. Furthermore, this study paves the way for more in-depth investigation, isolation and characterization of the molecules of this plant genus.Uniterms: Sucupira. Pterodon/phytochemistry. Pterodon/pharmacognosy. Diterpenes/biological activity. Isoflavones/biological activity. Medicinal plants.As plantas do gênero Pterodon (Fabaceae/Leguminosae), conhecidas popularmente como "sucupira branca" ou "faveira", encontram-se distribuídas pela região central do Brasil e são frequentemente utilizadas na medicina popular por suas propriedades antirreumáticas, analgésicas e antiinflamatórias. Nos últimos anos, o interesse por estas plantas tem aumentado consideravelmente. Os efeitos biológicos dos diferentes fitoextratos e metabólitos puros têm sido investigados em vários modelos experimentais in vivo e in vitro. A literatura descreve flavonóides, triterpenos, esteróides e apenas um trabalho mostra estudos com proteínas isoladas do gênero. Esta revisão apresenta de maneira geral as investigações farmacológicas e fitoquímicas de Pterodon, mostrando os principais compostos já estudados, sua composição química, focando na relação entre estas moléculas e sua atividade biológica. Mais ainda, nós abrimos as portas para maior investigação, isolamento e caracterização de moléculas deste gênero de plantas.Unitermos: Sucupira. Pterodon/fitoquímica. Pterodon/farmacognosia. Diterpenos/atividade biológica. Isoflavonas/atividade biológica. Plantas medicinais.

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The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review

Abstract: Corpora non agunt nisi fixata (Paul Ehrlich, 1909) The

Cited by 85 publications

References 234 publications

Proteinase inhibition and antioxidant activity of selected forage crops

Proteinase inhibition and antioxidant activity of selected forage crops

Ethnobotanical Study of Plants Used to Treat Asthma in the Maritime Region in Togo

Pharmaceutical properties of 'sucupira' (Pterodon spp.)

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